Target mRNA abundance dilutes microRNA and siRNA activity

Mapping and quantifying mammalian transcriptomes by RNA-Seq

2008 • 12,817 citations

Prediction of Mammalian MicroRNA Targets

2003 • 5,070 citations

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

2008 • 5,001 citations

Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs

2005 • 4,706 citations

MicroRNA Targeting Specificity in Mammals: Determinants beyond Seed Pairing

2007 • 3,708 citations

Human MicroRNA Targets

2004 • 3,702 citations

Widespread changes in protein synthesis induced by microRNAs

2008 • 3,372 citations

MicroRNA targets in Drosophila

2003 • 3,228 citations

A microRNA component of the p53 tumour suppressor network

2007 • 2,620 citations

MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells

2007 • 2,024 citations

Target mimicry provides a new mechanism for regulation of microRNA activity

2007 • 1,904 citations

The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution

2005 • 1,482 citations

Animal MicroRNAs Confer Robustness to Gene Expression and Have a Significant Impact on 3′UTR Evolution

2005 • 1,079 citations

Widespread siRNA “off-target” transcript silencing mediated by seed region sequence complementarity

2006 • 916 citations

An Abundance of Ubiquitously Expressed Genes Revealed by Tissue Transcriptome Sequence Data

2009 • 838 citations

Identification of Drosophila MicroRNA Targets

2003 • 792 citations

AceView: a comprehensive cDNA-supported gene and transcripts annotation

2006 • 621 citations

Transcripts Targeted by the MicroRNA-16 Family Cooperatively Regulate Cell Cycle Progression

2007 • 557 citations

Kinetic analysis of the RNAi enzyme complex

2004 • 537 citations

Transfection of small RNAs globally perturbs gene regulation by endogenous microRNAs

2009 • 510 citations

Profiling the HeLa S3 Transcriptome using Randomly Primed cDNA and Massively Parallel Short-Read Sequencing

2008 • 411 citations

Designing siRNA That Distinguish between Genes That Differ by a Single Nucleotide

2006 • 262 citations

mirWIP: microRNA target prediction based on microRNA-containing ribonucleoprotein–enriched transcripts

2008 • 207 citations

Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies

2007 • 176 citations

Experimental validation of the importance of seed complement frequency to siRNA specificity

2008 • 140 citations

Sequence context outside the target region influences the effectiveness of miR-223 target sites in the RhoB 3′UTR

2009 • 72 citations