Human Cytomegalovirus Mutant with Sequence-Dependent Resistance to the Phosphorothioate Oligonucleotide Fomivirsen (ISIS 2922)

Antiviral drug resistance

2006 • 222 citations

Antiviral activity of a phosphorothioate oligonucleotide complementary to RNA of the human cytomegalovirus major immediate-early region

1993 • 205 citations

A point mutation in the human cytomegalovirus DNA polymerase gene confers resistance to ganciclovir and phosphonylmethoxyalkyl derivatives

1993 • 177 citations

Inhibition of human cytomegalovirus immediate-early gene expression by an antisense oligonucleotide complementary to immediate-early RNA

1996 • 153 citations

Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus

1985 • 113 citations

Mutations in the herpes simplex virus major DNA-binding protein gene leading to altered sensitivity to DNA polymerase inhibitors

1985 • 84 citations

The implications of resistance to antiviral agents for herpesvirus drug targets and drug therapy

1991 • 74 citations

Isolation of Foscarnet-Resistant Human Cytomegalovirus Patterns of Resistance and Sensitivity to Other Antiviral Drugs

1991 • 71 citations

A WORKING HYPOTHESIS—VIRUS RESISTANCE DEVELOPMENT AS AN INDICATOR OF SPECIFIC ANTIVIRAL ACTIVITY

1977 • 50 citations

Antisense Nucleic Acids — Prospects for Antiviral Intervention

1993 • 24 citations