Promoter hypermethylation of multiple genes in carcinoma of the uterine cervix.

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

1996 • 5,667 citations

Prevalence of Human Papillomavirus in Cervical Cancer: a Worldwide Perspective

1995 • 3,371 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

Hypomethylation distinguishes genes of some human cancers from their normal counterparts

1983 • 2,392 citations

A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions.

1983 • 2,011 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

Alterations in DNA Methylation: A Fundamental Aspect of Neoplasia

1997 • 1,960 citations

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1998 • 1,852 citations

Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma.

1994 • 1,542 citations

A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer.

1984 • 1,308 citations

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia.

1999 • 1,252 citations

Aberrant methylation of p16 ^INK4a is an early event in lung cancer and a potential biomarker for early diagnosis

1998 • 953 citations

Detection of aberrant promoter hypermethylation of tumor suppressor genes in serum DNA from non-small cell lung cancer patients.

1999 • 920 citations

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.

1991 • 857 citations

Hypomethylation of DNA from Benign and Malignant Human Colon Neoplasms

1985 • 844 citations

E-cadherin expression is silenced by DNA hypermethylation in human breast and prostate carcinomas.

1995 • 803 citations

Microsatellite alterations in serum DNA of head and neck cancer patients

1996 • 653 citations

Analysis of the physical state of different human papillomavirus DNAs in intraepithelial and invasive cervical neoplasm

1991 • 585 citations

Gene promoter hypermethylation in tumors and serum of head and neck cancer patients.

2000 • 540 citations

Papillomaviruses in anogenital cancer as a model to understand the role of viruses in human cancers.

1989 • 522 citations

Analysis of adenomatous polyposis coli promoter hypermethylation in human cancer.

2000 • 522 citations

Promoter hypermethylation patterns of p16, O6-methylguanine-DNA-methyltransferase, and death-associated protein kinase in tumors and saliva of head and neck cancer patients.

2001 • 403 citations

Molecular Detection of Tumor Cells in Bronchoalveolar Lavage Fluid From Patients With Early Stage Lung Cancer

1999 • 349 citations

Mapping Patterns of CpG Island Methylation in Normal and Neoplastic Cells Implicates Both Upstream and Downstream Regions inde Novo Methylation

1997 • 323 citations

Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia.

1999 • 321 citations

In situ detection of the hypermethylation-induced inactivation of the p16 gene as an early event in oncogenesis

1999 • 321 citations

Hypermethylation of the DAP-Kinase CpG Island Is a Common Alteration in B-Cell Malignancies

1999 • 319 citations

Immortalization of human foreskin keratinocytes by various human papillomavirus DNAs corresponds to their association with cervical carcinoma

1989 • 247 citations

The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia.

1988 • 197 citations

Deletions of chromosome 3p are frequent and early events in the pathogenesis of uterine cervical carcinoma.

1997 • 168 citations

Methylation of the HIC-1 candidate tumor suppressor gene in human breast cancer

1998 • 153 citations

Loss of heterozygosity in cervical carcinoma: subchromosomal localization of a putative tumor-suppressor gene to chromosome 11q22-q24.

1994 • 147 citations

Association between high-risk HPV types, HLA DRB1* and DQB1* alleles and cervical cancer in British women

2000 • 124 citations

HIC1 hypermethylation is a late event in hematopoietic neoplasms.

1997 • 118 citations

Allelotyping of all chromosomal arms in invasive cervical cancer.

1996 • 84 citations

Methylation of p16 in primary gynecologic malignancy

1999 • 79 citations

Human papillomavirus (HPV) type 16 and 33 E6/E7 region transcripts in tonsillar carcinomas can originate from integrated and episomal HPV DNA

1992 • 59 citations

Genetic Alterations at 5p15: a Potential Marker for Progression of Precancerous Lesions of the Uterine Cervix

1995 • 58 citations

Screening in gynecologic cancers

1993 • 27 citations