Importance of P-Cadherin, β-Catenin, and Wnt5a/Frizzled for Progression of Melanocytic Tumors and Prognosis in Cutaneous Melanoma

Tissue microarrays for high-throughput molecular profiling of tumor specimens

1998 • 4,104 citations

β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

1999 • 3,566 citations

Thickness, Cross-Sectional Areas and Depth of Invasion in the Prognosis of Cutaneous Melanoma

1970 • 2,415 citations

The histogenesis and biologic behavior of primary human malignant melanomas of the skin.

1969 • 2,098 citations

Molecular classification of cutaneous malignant melanoma by gene expression profiling

2000 • 2,011 citations

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

1996 • 1,382 citations

Stabilization of β-Catenin by Genetic Defects in Melanoma Cell Lines

1997 • 1,215 citations

Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma

2002 • 945 citations

β-catenin signaling and cancer

1999 • 867 citations

Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients

1996 • 734 citations

Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation

2003 • 716 citations

The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors

1999 • 679 citations

Cadherins as Modulators of Cellular Phenotype

2003 • 656 citations

N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells.

2001 • 480 citations

Cell adhesion system and human cancer morphogenesis

2003 • 440 citations

Wnt/β-catenin signaling

2000 • 421 citations

Validation of Tissue Microarrays for Immunohistochemical Profiling of Cancer Specimens Using the Example of Human Fibroblastic Tumors

2001 • 399 citations

Cadherin and catenin alterations in human cancer

2002 • 389 citations

dishevelled is required during wingless signaling to establish both cell polarity and cell identity

1994 • 335 citations

Microarrays of bladder cancer tissue are highly representative of proliferation index and histological grade

2001 • 320 citations

Differential Localization of VE- and N-Cadherins in Human Endothelial Cells: VE-Cadherin Competes with N-Cadherin for Junctional Localization

1998 • 297 citations

E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro

1994 • 289 citations

Frequent Nuclear/Cytoplasmic Localization of β-Catenin without Exon 3 Mutations in Malignant Melanoma

1999 • 278 citations

β-Catenin Expression Pattern in Stage I and II Ovarian Carcinomas

1999 • 225 citations

Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling

2005 • 213 citations

Gene expression profiles of pancreatic cancer and stromal desmoplasia

2001 • 212 citations

Shifts in cadherin profiles between human normal melanocytes and melanomas.

1996 • 211 citations

Loss of nuclear p16 protein expression correlates with increased tumor cell proliferation (Ki-67) and poor prognosis in patients with vertical growth phase melanoma.

2000 • 210 citations

Aberrant expression of the growth factor Wnt-5A in human malignancy.

1995 • 191 citations

Cadherin repertoire determines partner-specific gap junctional communication during melanoma progression

2000 • 189 citations

Independent prognostic impact of lymphatic vessel density and presence of low-grade lymphangiogenesis in cutaneous melanoma.

2003 • 180 citations

Cellular Adhesion Pathways and Metastatic Potential of Human Melanoma

2002 • 165 citations

Expresson of Vascular Endothelial Growth Factor, Its Receptors (FLT-1, KDR) and TSP-1 Related to Microvessel Density and Patient Outcome in Vertical Growth Phase Melanomas

2001 • 154 citations

Prognostic Impact of Alterations in P-Cadherin Expression and Related Cell Adhesion Markers in Endometrial Cancer

2004 • 151 citations

The high molecular weight isoforms of basic fibroblast growth factor (FGF‐2): an insight into an intracrine mechanism

2000 • 150 citations

P-cadherin expression in breast carcinoma indicates poor survival

1999 • 149 citations

Importance of Vascular Phenotype by Basic Fibroblast Growth Factor, and Influence of the Angiogenic Factors Basic Fibroblast Growth Factor/Fibroblast Growth Factor Receptor-1 and Ephrin-A1/EphA2 on Melanoma Progression

2002 • 135 citations

Alterations in cadherin and catenin expression during the biological progression of melanocytic tumours

1999 • 135 citations

Loss of beta-catenin expression associated with disease progression in malignant melanoma

2001 • 132 citations

Alterations and prognostic significance of p16 and p53 protein expression in subgroups of cutaneous melanoma

1997 • 124 citations

Regulation of E- and P-Cadherin Expression Correlated with Melanocyte Migration and Diversification

1999 • 115 citations

Expression of mutant nuclear β-catenin correlates with non-invasive hepatocellular carcinoma, absence of portal vein spread, and good prognosis

2001 • 114 citations

Gene-expression profiling in human cutaneous melanoma

2003 • 104 citations

Roles of E- and P-cadherin in the human skin

1997 • 102 citations

The Prognostic Significance of P-Cadherin in Infiltrating Ductal Breast Carcinoma

2001 • 86 citations

Reduced beta-catenin expression in the cytoplasm of advanced-stage superficial spreading malignant melanoma.

2003 • 83 citations

Angiogenesis is prognostically important in vertical growth phase melanomas.

1999 • 80 citations

Independent prognostic importance of vascular invasion in nodular melanomas

1996 • 71 citations

Cadherin expression pattern in melanocytic tumors more likely depends on the melanocyte environment than on tumor cell progression

2003 • 62 citations

Wnt ligand expression in malignant melanoma: pilot study indicating correlation with histopathological features

2003 • 53 citations

Reversion of uroepithelial cell tumorigenesis by the ectopic expression of human wnt-5a.

1997 • 42 citations

Altered expression of cell cycle regulators Cyclin D1, p14, p16, CDK4 and Rb in nodular melanomas

2004 • 39 citations