Cocarcinogens and Tumor Promoters and Their Environmental Importance

Some current perspectives on chemical carcinogenesis in humans and experimental animals: Presidential Address.

1978 • 938 citations

New principle for the analysis of chemical carcinogenesis

1976 • 788 citations

Cancer. A Comprehensive Treatise

1975 • 742 citations

Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis.

1977 • 541 citations

Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene.

1971 • 412 citations

The Cocarcinogenic Action of Croton Resin

1941 • 386 citations

Initiation of chemical carcinogenesis requires cell proliferation

1978 • 345 citations

Cocarcinogenic and Tumor-Promoting Agents in Tobacco Carcinogenesis2

1976 • 344 citations

Tumor-promoting Agents in Two-stage Carcinogenesis1

2015 • 296 citations

Comparative enhancing effects of phenobarbital, amobarbital, diphenylhydantoin, and dichlorodiphenyltrichloroethane on 2-acetylaminofluorene-induced hepatic tumorigenesis in the rat.

1975 • 257 citations

Carcinogens: Identification and mechanisms of action

1980 • 251 citations

The tumor-promoting action of phenol and related compounds for mouse skin.

1959 • 244 citations

Induction of resistant hepatocytes as a new principle for a possible short-term in vivo test for carcinogens.

1980 • 243 citations

Regression and persistence of hyperplastic hepatic nodules induced by N-2-Fluorenylacetamide and their relationship to hepatocarcinogenesis.

1971 • 221 citations

Phenotypic diversity as an early property of putative preneoplastic hepatocyte populations in liver carcinogenesis.

1980 • 203 citations

Cellular analysis of liver carcinogenesis: the induction of large hyperplastic nodules in the liver with 2-fluorenylacetamide or ethionine and some aspects of their morphology and glycogen metabolism.

1967 • 202 citations

Histochemistry of Gamma-Glutamyl Transpeptidase in Rat Liver During Aflatoxin B1-Induced Carcinogenesis2

1975 • 181 citations

Sequential Aspects of Chemical Carcinogenesis: Skin

1975 • 159 citations

Quantitative histochemical and autoradiographic studies of hepatocarcinogenesis in rats fed 2-acetylaminofluorene followed by phenobarbital.

1978 • 157 citations

Carcinogenic Activity of Alkylating Agents2

1974 • 152 citations

Kinetics of induction and growth of precancerous liver-cell foci, and liver tumour formation by diethylnitrosamine in the rat

1975 • 151 citations

Carcinogenicity of Halogenated Olefinic and Aliphatic Hydrocarbons in Mice<xref ref-type="fn" rid="FN2">2</xref>

1979 • 142 citations

Activation by Chemical Carcinogens of γ-Glutamyl Transpeptidase in Rat and Mouse Liver 2

1973 • 142 citations

CELL PROLIFERATION AND EXPERIMENTAL LIVER CANCER

1976 • 141 citations

Kinetics of induction and growth of enzyme-deficient islands involved in hepatocarcinogenesis.

1976 • 129 citations

Liver Carcinomas Induced in Rats by Single Administration of Dimethylnitrosamine After Partial Hepatectomy

1971 • 126 citations

Quantitative Study on Foci of Altered Liver Cells Induced in the Rat by a Single Dose of Diethylnitrosamine and Partial Hepatectomy<xref ref-type="fn" rid="FN1">2</xref>

1972 • 125 citations

Long‐term administration of ddt or phenobarbital‐na in wistar rats

1977 • 124 citations

Enhancement of Spontaneous Hepatic Tumorigenesis in C3H Mice by Dietary Phenobarbital2

1973 • 122 citations

Enhancement of Rat Hepatocellular-Altered Foci by the Liver Tumor Promoter Phenobarbital: Evidence That Foci Are Precursors of Neoplasms and That the Promoter Acts on Carcinogen-Induced Lesions23

1978 • 107 citations

THE PATHOLOGY OF EXPERIMENTAL LIVER CELL CANCER

1976 • 90 citations

Enzyme patterns in human hepatocellular carcinoma.

1980 • 83 citations

Carcinogens, identification and mechanisms of action

1979 • 82 citations

Induction of foci of altered, γ-glutamyltranspeptidase-positive hepatocytes in carcinogen-treated rats fed a choline-deficient diet

1979 • 81 citations

Nature of Early Appearing, Carcinogen-Induced Liver Lesions Resistant to Iron Accumulation 2 3

1976 • 80 citations

Dose-response studies with a pure tumor-promoting agent, phorbol myristate acetate.

1973 • 79 citations

Enhancing effect of phenobarbital on the development of enzyme-altered islands and hepatocellular carcinomas initiated by 3'-methyl-4-(dimethylamino) azobenzene or diethylnitrosamine.

1978 • 77 citations

Gamma-Glutamyl Transpeptidase: A Positive Marker for Cultured Rat Liver Cells Derived From Putative Premalignant and Malignant Lesions2

1978 • 76 citations

Effect of a single treatment with the alkylating carcinogens dimethylnitrosamine, diethylnitrosamine and methyl methanesulphonate, on liver regenerating after partial hepatectomy

1975 • 76 citations

Recent findings on the carcinogenicity of chlorinated olefins.

1977 • 76 citations

Ornithine decarboxylase activity, cell proliferation, and tumor promotion in mouse epidermis in vivo.

1979 • 73 citations

Identification of Some Polynuclear Aromatic Hydrocarbons in Cigarette-Smoke Condensate<xref ref-type="fn" rid="FN1">2</xref>,<xref ref-type="fn" rid="FN2">3</xref>

1958 • 72 citations

The correlation of promotion of tumour growth and of induction of hyperplasia in epidermal two-stage carcinogenesis

1968 • 72 citations

Liver cell cancer

1976 • 72 citations

7,12-Dimethylbenz(α)anthracene and hepatic neoplasia in regenerating rat liver

1970 • 65 citations

Renal Tumours in Rats following Injection of Dimethylnitrosamine at Birth

1964 • 64 citations

Promotion by dietary phenobarbital of hepatocarcinogenesis by 2-methyl-N,N-dimethyl-4-aminoazobenzene in the rat.

1979 • 64 citations

Effects of a choline-devoid diet on the emergence of gamma-glutamyltranspeptidase-positive foci in the liver of carcinogen-treated rats.

1979 • 63 citations

The use of the D-T diaphorase for the detection of foci of early neoplastic transformation in rat liver

1978 • 63 citations

Systemic two-stage carcinogenesis in the epithelium of the forestomach of mice using 7,12-dimethylbenz(a)anthracene as initiator and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate as promoter.

1979 • 62 citations

Hyperbasophilic foci as sites of neoplastic transformation in hepatic parenchyma.

1971 • 59 citations

Chemical Carcinogenesis

1976 • 56 citations

Increased Carcinogenic Action of Dimethylnitrosamine after Prior Administration of Carbon Tetrachloride

1973 • 55 citations

HISTOCHEMICAL DEMONSTRATION OF INCREASED ACTIVITY OF γ-GLUTAMYL TRANSPEPTIDASE IN RAT LIVER DURING HEPATOCARCINOGENESIS

1976 • 53 citations

Rapid production of hyperplastic liver nodules in rats treated with carcinogenic chemicals: a new approach for an in vivo short-term screening test for hepatocarcinogens.

1977 • 52 citations

Persistence and Growth of Rat Liver Neoplastic Nodules Following Cessation of Carcinogen Exposure&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1979 • 52 citations

Enhancement of diethylnitrosamine hepatocarcinogenesis in rats by exposure to polychlorinated biphenyls or phenobarbital

1976 • 51 citations

Enhancing Effect of Inducers of Liver Microsomal Enzymes on Induction of Hyperplastic Liver Nodules by &lt;italic&gt;N&lt;/italic&gt;-2-Fluorenylacetamide in Rats&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1979 • 48 citations

Long-term effects of phenobarbitone-Na on male Fischer rats

1978 • 46 citations

The effect of long-term administration of phenobarbitone in CF-1 mice

1975 • 45 citations

gamma-Glutamyl transpeptidase and malignant transformation of cultured liver cells.

1979 • 43 citations

Röntgenstrukturanalyse des Neophorbols

1967 • 40 citations

Initiators and promoters in tobacco carcinogenesis.

1968 • 38 citations

The Polynuclear Aromatic Hydrocarbons in Cigarette-Smoke Condensate. II&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;

1958 • 34 citations

Effects of structural changes on the tumor-promoting activity of phorbol myristate acetate on mouse skin.

1979 • 33 citations

Role of Injury and Hyperplasia in the Induction of Hepatocellular Carcinoma

1961 • 32 citations

Induction of enzyme-altered islands in rat liver by tryptophan pyrolysis products

1979 • 29 citations

The stability of events in the natural history of neoplasia.

1977 • 28 citations

Short-term in vivo initiation/promotion bioassay for hepatocarcinogens.

1980 • 26 citations

Definition of stages during hepatocarcinogenesis in the rat: potential application to the evaluation of initiating and promoting agents in the environment.

1978 • 26 citations

Effect of phenobarbital on induction of liver and lung tumors by dimethylnitrosamine in newborn mice.

1979 • 25 citations

Über den Giftstoff im Krotonöl. II. Zur Konstitution von Krotophorbolon

1934 • 19 citations

The structure and stereochemistry of phorbol, diterpene parent of co-carcinogens of croton oil

1967 • 19 citations

Formation of pre-neoplastic hepatocellular foci by vinyl bromide in newborn rats

1979 • 19 citations

The Effect of Dietary Phenobarbital on the Induction of Skin Tumors in Hairless Mice with 7,12-Dimethylbenz[A]Anthracene

1975 • 16 citations

Promotional Effect of Sodium Barbiturate on Intestinal Tumors Induced in Rats by Dimethylhydrazine&lt;xref ref-type="fn" rid="FN2"&gt;2&lt;/xref&gt;

1979 • 11 citations

Induction of foci of altered hepatocytes by a single injection of azaserine to rats

1979 • 10 citations

Multicarcinogenicity of N-nitrosobutylurea in mice and rats as demonstrated by host conditioning.

1973 • 8 citations

Comparison of the Effect of the Carcinogen &lt;italic&gt;N&lt;/italic&gt;-Hydroxy-&lt;italic&gt;N-2&lt;/italic&gt;-fluorenylacetamide in Infant and Weanling Rats

1970 • 7 citations

Über den Giftstoff des Crotonöles. V. Die Gewinnung von Crotonharz, Dünnem Öl und Phorbol aus dem Crotonöl durch Alkoholyse

1942 • 7 citations

Tumor promoting and cocarcinogenic effects of some non-ionic lipophilic-hydrophilic (surface active) agents; an experimental study on skin tumors in mice.

1956 • 4 citations