A prospective, randomized, double-blind, controlled clinical trial of enteral immunonutrition in the critically ill

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

1992 • 12,726 citations

APACHE II-A Severity of Disease Classification System

1986 • 12,607 citations

APACHE II

1985 • 12,347 citations

The Natural History of the Systemic Inflammatory Response Syndrome (SIRS)

1995 • 2,007 citations

The Effect of Dietary Supplementation with n—3 Polyunsaturated Fatty Acids on the Synthesis of Interleukin-1 and Tumor Necrosis Factor by Mononuclear Cells

1989 • 1,951 citations

Early Enteral Feeding, Compared With Parenteral, Reduces Postoperative Septic Complications The Results of a Meta-Analysis

1992 • 1,384 citations

Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein

1996 • 1,217 citations

Therapeutic intervention scoring system

1974 • 1,203 citations

Enteral Versus Parenteral Feeding Effects on Septic Morbidity After Blunt and Penetrating Abdominal Trauma

1992 • 1,163 citations

Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group

1994 • 920 citations

Efficacy and Safety of Monoclonal Antibody to Human Tumor Necrosis Factor α in Patients With Sepsis Syndrome

1995 • 805 citations

Recombinant Human Interleukin 1 Receptor Antagonist in the Treatment of Patients With Sepsis Syndrome

1994 • 714 citations

Early enteral administration of a formula (Impact Registered Trademark) supplemented with arginine, nucleotides, and fish oil in intensive care unit patients

1995 • 601 citations

Immune and Metabolic Effects of Arginine in the Surgical Patient

1988 • 436 citations

Dietary polyunsaturated fatty acids and eicosanoids: potential effects on the modulation of inflammatory and immune cells: an overview.

1990 • 417 citations

A Randomized Trial of Isonitrogenous Enteral Diets After Severe Trauma

1996 • 387 citations

CLINICAL BENEFITS OF AN IMMUNE-ENHANCING DIET FOR EARLY POSTINJURY ENTERAL FEEDING

1994 • 313 citations

Fatty acid intake and Kupffer cell function: fish oil alters eicosanoid and monokine production to endotoxin stimulation.

1988 • 248 citations

Early postoperative enteral nutrition with arginine-omega-3 fatty acids and ribonucleic acid-supplemented diet versus placebo in cancer patients

1995 • 213 citations

Arginine and immune function.

1990 • 187 citations

lnterhospital comparisons of patient outcome from intensive care

1989 • 169 citations

Postoperative Enteral vs Parenteral Nutrition

1986 • 154 citations

Improvement in immune function in ICU patients by enteral nutrition supplemented with arginine, RNA, and menhaden oil is independent of nitrogen balance.

1991 • 138 citations

Effect of Dietary Nucleotides on Response to Bacterial Infections

1986 • 130 citations

Modulation of postoperative immune response by enteral nutrition with a diet enriched with arginine, RNA, and omega-3 fatty acids in patients with upper gastrointestinal cancer.

1995 • 122 citations

Should morbidity replace mortality as an endpoint for clinical trials in intensive care?

1995 • 117 citations

Interaction between Nutrients, Pro-Inflammatory Cytokines and Inflammation

1996 • 104 citations

Chronic TPA treatment inhibits expression of proximal tubule-specific properties by LLC-PK1 cells

1996 • 68 citations

Arginine Enhances T‐Cell Responses in Athymic Nude Mice

1992 • 53 citations

Immunonutrition and enteral hyperalimentation of critically ill patients

1992 • 41 citations

Effect of a Diet Deficient in Essential Fatty Acids on the Translocation of Intestinal Bacteria

1992 • 29 citations

The effect of dietary glutamine and dietary RNA on ileal flora, ileal histology, and bacterial translocation in mice.

1990 • 28 citations

The impact of immunonutrition

1995 • 18 citations

Perioperative nutritional support: A tale of two studies

1995 • 5 citations