Insulin Resistance, Hyperinsulinemia, Dyslipidemia, Hypertension, and Accelerated Atherosclerosis

Role of Insulin Resistance in Human Disease

1988 • 12,099 citations

Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 Years

1974 • 6,354 citations

Insulin Resistance in Essential Hypertension

1987 • 2,386 citations

Relation of Body Fat Distribution to Metabolic Complications of Obesity*

1982 • 1,919 citations

Hyperinsulinemia. A link between hypertension obesity and glucose intolerance.

1985 • 1,485 citations

Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution.

1983 • 1,455 citations

Effect of Insulin and Glucose Infusions on Sympathetic Nervous System Activity in Normal Man

1981 • 1,168 citations

The effect of insulin on renal handling of sodium, potassium, calcium, and phosphate in man.

1975 • 1,114 citations

Relationship of plasma insulin levels to the incidence of myocardial infarction and coronary heart disease mortality in a middle-aged population

1980 • 754 citations

Incidence and precursors of hypertension in young adults: The Framingham offspring study

1987 • 749 citations

Lipoprotein metabolism in diabetes mellitus.

1987 • 656 citations

The effect of insulin on renal sodium metabolism

1981 • 633 citations

Relationship of Androgenic Activity to Body Fat Topography, Fat Cell Morphology, and Metabolic Aberrations in Premenopausal Women*

1983 • 589 citations

Insulin and Atheroma: 20-Yr Perspective

1990 • 584 citations

The effects of glucose and insulin on renal electrolyte transport.

1976 • 454 citations

Resistance to Insulin-Stimulated-Glucose Uptake in Patients with Hypertension*

1988 • 433 citations

SERUM-INSULIN IN ESSENTIAL HYPERTENSION AND IN PERIPHERAL VASCULAR DISEASE

1966 • 328 citations

Insulin Resistance, Glucose Intolerance and Hyperinsulinemia in Patients with Hypertension

1989 • 323 citations

Do Upper-Body and Centralized Adiposity Measure Different Aspects of Regional Body-Fat Distribution? Relationship to Non-Insulin-Dependent Diabetes Mellitus, Lipids, and Lipoproteins

1987 • 306 citations

EVIDENCE FOR AN INCREASED RISK FOR HYPERTENSION WITH CENTRALLY LOCATED BODY FAT AND THE EFFECT OF RACE AND SEX ON THIS RISK

1984 • 305 citations

Familial dyslipidemic hypertension. Evidence from 58 Utah families for a syndrome present in approximately 12% of patients with essential hypertension

1988 • 302 citations

Reduced Activity of the Red-Cell Sodium-Potassium Pump in Human Obesity

1980 • 298 citations

Insulin and blood pressure in obesity.

1985 • 281 citations

Possible role of cytosolic free calcium concentrations in mediating insulin resistance of obesity and hyperinsulinemia.

1988 • 271 citations

Insulin Infusion in Conscious Dogs

1982 • 271 citations

A high affinity calcium-stimulated magnesium-dependent adenosine triphosphatase in rat adipocyte plasma membranes.

1980 • 269 citations

Close correlation of intra-abdominal fat accumulation to hypertension in obese women.

1990 • 265 citations

Hyperinsulinemia, upper body adiposity, and cardiovascular risk factors in non-diabetics

1988 • 262 citations

Evidence for an Association of High Blood Pressure and Hyperinsulinemia in Obese Man

1986 • 256 citations

Insulin stimulates volume absorption in the rabbit proximal convoluted tubule.

1987 • 246 citations

The existence of an optimal range of cytosolic free calcium for insulin-stimulated glucose transport in rat adipocytes.

1987 • 230 citations

Relationship of Fat Distribution to Glucose Tolerance: Results of Computed Tomography in Male Participants of the Normative Aging Study

1986 • 228 citations

Effects of Body Composition on Insulin Sensitivity

1983 • 223 citations

Obesity, lipids, and glucose intolerance The Framingham Study

1979 • 209 citations

Identification of two molecular forms of (Na+,K+)-ATPase in rat adipocytes. Relation to insulin stimulation of the enzyme.

1985 • 204 citations

Multivariate analysis of the relationship of seven variables to blood pressure: Findings of the Chicago Heart Association Detection Project in Industry, 1967–1972

1975 • 202 citations

Postprandial hyperinsulinemia in patients with mild essential hypertension.

1985 • 166 citations

Hypertension in Elderly Patients

1989 • 155 citations

Atherosclerosis in diabetes: The role of hyperinsulinemia

1988 • 151 citations

Familial Dyslipidemic Hypertension

1988 • 148 citations

Insulin resistance and blood pressure in young black men.

1990 • 147 citations

The Association of Borderline Hypertension With Target Organ Changes and Higher Coronary Risk

1990 • 143 citations

Control by insulin of sodium potassium and water excretion by the isolated dog kidney

1971 • 135 citations

Blood pressure, insulin, and glycemia in nondiabetic subjects

1986 • 131 citations

Body fat patterning and blood pressure in children and young adults. The Bogalusa Heart Study.

1987 • 130 citations

Difference in Diabetic and Nondiabetic Fat Distribution Patterns by Skinfold Measurements

1969 • 130 citations

Is insulin the link between hypertension and obesity?

1985 • 128 citations

Plasma lipoprotein levels in treated and untreated hypertensive men and women. The National Heart Foundation of Australia Risk Factor Prevalence Study.

1985 • 124 citations

Body Composition and Glucose Metabolism in Hypertensive Middle‐aged Males

1976 • 122 citations

Exchangeable sodium and renin in hypertensive diabetic patients with and without nephropathy.

1985 • 121 citations

Pressor factors and responsiveness in hypertension accompanying diabetes mellitus.

1985 • 119 citations

Chronic hyperinsulinemia and blood pressure. Interaction with catecholamines?

1990 • 114 citations

FATNESS AND FAT PATTERNS: ASSOCIATIONS WITH PLASMA LIPIDS AND BLOOD PRESSURES IN ADULTS, 18 TO 57 YEARS OF AGE1

1987 • 107 citations

Insulin-mediated glucose metabolism in the relationship between dietary intake and sympathetic nervous system activity.

1985 • 103 citations

Relative contribution of obesity and body fat distribution to alterations in glucose insulin homeostasis: predictive values of selected indices in premenopausal women

1989 • 101 citations

The insulin receptor and calmodulin. Calmodulin enhances insulin-mediated receptor kinase activity and insulin stimulates phosphorylation of calmodulin.

1986 • 101 citations

Blood pressure reduction after oral glucose loading and its relation to age, blood pressure and insulin

1987 • 100 citations

Red cell sodium countertransport and cotransport in normotensive and hypertensive blacks.

1984 • 93 citations

Hypertension as a disease of carbohydrate and lipoprotein metabolism

1989 • 91 citations

The Effect of Insulin on Vascular Reactivity to Norepinephrine

1977 • 91 citations

Hypotensive and sedative effects of insulin in autonomic failure.

1987 • 87 citations

Relation between blood pressure, weight, and plasma sugar and serum insulin levels in schoolchildren aged 9-12 years in Westland, Holland.

1976 • 87 citations

Sodium Retention Accompanying Insulin Treatment of Diabetes Mellitus

1974 • 82 citations

Role of cellular calcium metabolism in abnormal glucose metabolism and diabetic hypertension

1989 • 77 citations

Cardiovascular responses to insulin in the absence of hypoglycemia

1962 • 76 citations

High-density lipoprotein cholesterol in blacks and whites: Potential ramifications for coronary heart disease

1984 • 66 citations

PLASMA GLUCOSE LEVEL RELATED TO BLOOD PRESSURE IN 272 CHILDREN, AGES 7–15 YEARS, SAMPLED FROM A TOTAL BIRACIAL POPULATION1

1981 • 66 citations

HYPERINSULINEMIA AND ELEVATED BLOOD PRESSURE: CAUSE, CONFOUNDER, OR COINCIDENCE?

1990 • 64 citations

Hypertension and Diabetes

1988 • 64 citations

Hypertension in the elderly

1987 • 63 citations

Impaired calcium metabolism associated with hypertension in Zucker obese rats

1990 • 63 citations

Acute effects of insulin on plasma noradrenaline and the cardiovascular system

1980 • 62 citations

A Na+-Ca2+ exchange process in isolated sarcolemmal membranes of mesenteric arteries from WKY and SHR rats

1985 • 59 citations

Type of obesity and blood pressure.

1982 • 58 citations

Hyperinsulinaemia and other metabolic disturbances in well-controlled hypertensive men and women: an epidemiological study of the Dalby population

1990 • 55 citations

Insulin resistance and hypertension

1990 • 55 citations

Ca2+-Mg2+-ATPase activity of human red blood cells in healthy and diabetic volunteers

1987 • 54 citations

Mechanisms of Hypertension in Diabetes

1991 • 53 citations

The effect of insulin on vascular reactivity to norepinephrine

1977 • 47 citations

Altered erythrocyte and plasma sodium and potassium in hypertension, a facet of hyperinsulinemia.

1988 • 43 citations

The Na+/H+ Antiport, Cytosolic Free Ca2+, and Essential Hypertension: A Hypothesis

1988 • 40 citations

Role of Enhanced Sympathetic Nervous System Activity and Reduced Na+,K+-Dependent Adenosine Triphosphatase Activity in Maintenance of Elevated Blood Pressure in Obesity: Effects of Weight Loss

1982 • 35 citations

Altered cation transport in non-insulin-dependent diabetic hypertension

1988 • 34 citations

Red-cell sodium-lithium countertransport and fractional excretion of lithium in normal and hypertensive humans.

1989 • 33 citations

Na+-H+ exchange and Na+-dependent transport systems in streptozotocin diabetic rat kidneys

1987 • 24 citations

Abnormal Ca²⁺-ATPase Activity in Erythrocytes of Non-Insulin-Dependent Diabetic Rats

1990 • 23 citations

Increased Sodium – Lithium Countertransport in Black Non – Insulin-dependent Diabetic Hypertensives

1990 • 22 citations

Activation of dopamine beta-monooxygenase by external and internal electron donors in resealed chromaffin granule ghosts.

1987 • 22 citations

(Na++K+)-ATPase activity in kidney basolateral membranes of non insulin dependent diabetic rats

1986 • 20 citations

Characteristics of Calmodulin Phosphorylation by the Insulin Receptor Kinase*

1988 • 19 citations

Relationship between hypertension and subtle and overt abnormalities of carbohydrate metabolism.

1990 • 12 citations

The East Baltimore study: the relationship of lipids and lipoproteins to selected cardiovascular risk factors in an inner city Black adult population

1983 • 8 citations

Hypertension in an aging population: Problems and opportunities

1991 • 7 citations