Distribution and function of human ventricular beta adrenergic receptors in congestive heart failure

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

A simple, rapid, and sensitive DNA assay procedure

1980 • 5,006 citations

Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

1982 • 2,259 citations

Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure.

1986 • 1,297 citations

A simple, sensitive method for the assay of adenyl cyclase.

1968 • 996 citations

Assessment of the beta-adrenergic receptor pathway in the intact failing human heart: progressive receptor down-regulation and subsensitivity to agonist response.

1986 • 564 citations

A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data.

1980 • 545 citations

Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart.

1988 • 545 citations

Deficient production of cyclic AMP: pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure.

1987 • 500 citations

Decreased Lymphocyte Beta-Adrenergic-Receptor Density in Patients with Heart Failure and Tolerance to the Beta-Adrenergic Agonist Pirbuterol

1981 • 331 citations

Studies on sodium-potassium-activated adenosinetriphosphatase. IV. Correlation with cation transport sensitive to cardiac glycosides

1962 • 234 citations

Externalization of beta-adrenergic receptors promoted by myocardial ischemia

1985 • 164 citations

Decreased stimulatory guanosine triphosphate binding protein in dogs with pressure-overload left ventricular failure.

1988 • 138 citations

Loss of high affinity cardiac beta adrenergic receptors in dogs with heart failure.

1985 • 130 citations

Relationship between an altered membrane form and a low affinity form of the beta-adrenergic receptor occurring during catecholamine-induced desensitization. Evidence for receptor internalization.

1984 • 86 citations

Translocation and Uncoupling of theβ-Adrenergic Receptor in Rat Lung after Catecholamine Promoted Desensitizationin Vivo

1984 • 71 citations

Mechanisms and time course of beta1 adrenoceptor desensitisation in mammalian cardiac myocytes

1986 • 43 citations

The Vasopressin-sensitive Adenylate Cyclase of the Rat Renal Medulla

1973 • 37 citations

Mechanisms of beta-adrenergic receptor regulation in cultured chick heart cells. Role of cytoskeleton function and protein synthesis.

1985 • 33 citations

Receptors for beta-adrenergic agonists in cultured chick ventricular cells. Relationship between agonist binding and physiologic effect.

1985 • 24 citations