Phosphorylation of FADD is critical for sensitivity to anticancer drug-induced apoptosis

The Fas Death Factor

1995 • 4,070 citations

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

2001 • 2,488 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

CD95's deadly mission in the immune system

2000 • 1,714 citations

Therapeutic potential of inhibition of the NF-κB pathway in the treatment of inflammation and cancer

2001 • 1,548 citations

Paclitaxel-induced cell death

2000 • 618 citations

Microtubules and actin filaments: dynamic targets for cancer chemotherapy

1998 • 614 citations

From receptors to stress-activated MAP kinases

1999 • 525 citations

Microtubule-interfering Agents Activate c-Jun N-terminal Kinase/Stress-activated Protein Kinase through Both Ras and Apoptosis Signal-regulating Kinase Pathways

1998 • 353 citations

Fas Ligand-independent, FADD-mediated Activation of the Fas Death Pathway by Anticancer Drugs

1999 • 320 citations

Taxol sensitizes human astrocytoma cells to radiation.

1992 • 267 citations

MEK Kinase 1, a Substrate for DEVD-Directed Caspases, Is Involved in Genotoxin-Induced Apoptosis

1998 • 236 citations

Mitogen-Activated Protein Kinase Kinase Kinase 1 Activates Androgen Receptor-Dependent Transcription and Apoptosis in Prostate Cancer

1999 • 211 citations

Androgen Receptor Acetylation Governs trans Activation and MEKK1-Induced Apoptosis without Affecting In Vitro Sumoylation and trans-Repression Function

2002 • 165 citations

Phosphorylation of FADD/ MORT1 at Serine 194 and Association with a 70-kDa Cell Cycle-Regulated Protein Kinase

2000 • 152 citations

Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: A potential link between genome surveillance and apoptosis

2003 • 140 citations

Protein kinase Cδ amplifies ceramide formation via mitochondrial signaling in prostate cancer cells

2002 • 127 citations

MEK Kinase 1 (MEKK1) Transduces c-Jun NH2-terminal Kinase Activation in Response to Changes in the Microtubule Cytoskeleton

1999 • 125 citations

A Function of Fas-Associated Death Domain Protein in Cell Cycle Progression Localized to a Single Amino Acid at Its C-Terminal Region

2003 • 119 citations

Potentiation of apoptosis by low dose stress stimuli in cells expressing activated MEK kinase 1

1997 • 71 citations

Differential Involvement of MEK Kinase 1 (MEKK1) in the Induction of Apoptosis in Response to Microtubule-targeted Drugsversus DNA Damaging Agents

1999 • 71 citations

Paclitaxel shows cytotoxic activity in human hepatocellular carcinoma cell lines

1999 • 70 citations

Taxol and radiation.

1993 • 65 citations

Enhancement of paclitaxel activity against hormone-refractory prostate cancer cells in vitro and in vivo by quinacrine

1997 • 49 citations

Contributions of mitogen‐activated protein kinase and nuclear factor kappa B to N‐(4‐hydroxyphenyl)retinamide–induced apoptosis in prostate cancer cells

2002 • 46 citations

c‐Jun NH₂‐terminal kinase‐dependent fas activation contributes to etoposide‐induced apoptosis in p53‐mutated prostate cancer cells

2003 • 43 citations

Phosphorylation of Fas‐associated Death Domain Contributes to Enhancement of Etoposide‐induced Apoptosis in Prostate Cancer Cells

2002 • 26 citations

Requirement of c‐jun for testosterone‐induced sensitization to N‐(4‐hydroxyphenyl)retinamide–induced apoptosis

2003 • 26 citations