DNA topoisomerases and DNA repair

DNA TOPOISOMERASES

1985 • 1,524 citations

DNA repair in an active gene: Removal of pyrimidine dimers from the DHFR gene of CHO cells is much more efficient than in the genome overall

1985 • 1,233 citations

Topoisomerase II is a structural component of mitotic chromosome scaffolds.

1985 • 751 citations

DNA topoisomerase II is required for condensation and separation of mitotic chromosomes in S. pombe

1987 • 691 citations

A general mechanism for microsomal activation of quinone anticancer agents to free radicals.

1978 • 645 citations

Topoisomerase II: A specific marker for cell proliferation.

1986 • 434 citations

DNA Topoisomerases: Enzymes That Control DNA Conformation

1985 • 337 citations

Recent studies of DNA topoisomerases

1987 • 323 citations

Mutations in the gene coding for Escherichia coli DNA topoisomerase I affect transcription and transposition.

1981 • 284 citations

Drosophila DNA topoisomerase I is associated with transcriptionally active regions of the genome.

1984 • 225 citations

Relationship between the intracellular effects of camptothecin and the inhibition of DNA topoisomerase I in cultured L1210 cells.

1987 • 141 citations

DNA repair-associated ADP-ribosylation in vivo. Modification of histone H1 differs from that of the principal acceptor proteins.

1984 • 138 citations

DNA unwinding and inhibition of mouse leukemia L1210 DNA topoisomerase I by intercalators

1987 • 134 citations

Dependence of mammalian DNA replication on DNA supercoiling II. Effects of novobiocin on DNA synthesis in Chinese hamster ovary cells

1979 • 114 citations

Novobiocin; an inhibitor of the repair of UV-induced but not X-ray-induced damage in mammalian cells

1979 • 112 citations

Coumermycin A1: a preferential inhibitor of replicative DNA synthesis in Escherichia coli. I. In vivo characterization

1976 • 106 citations

Dependence of mammalian DNA synthesis on DNA supercoiling. III Characterization of the inhibition of replicative and repair-type DNA synthesis by novobiocin and nalidixic acid

1981 • 96 citations

Novobiocin inhibition of DNA excision repair may occur through effects on mitochondrial structure and ATP metabolism, not on repair topoisomerases

1985 • 90 citations

Novobiocin inhibition of simian virus 40 DNA replication

1980 • 85 citations

Eukaryotic DNA repair is blocked at different steps by inhibitors of DNA topoisomerases and of DNA polymerases α and β

1982 • 78 citations

Elevated DNA topoisomerase II activity in nitrogen mustard-resistant human cells.

1987 • 75 citations

Lesions induced in dna by ultraviolet light are repaired at the nuclear cage

1984 • 75 citations

The reconstitution of higher-order DNA structure after X-irradiation of mammalian cells

1983 • 67 citations

Poly(ADP-ribose) synthesis following DNA damage in cells heterozygous or homozygous for the xeroderma pigmentosum genotype.

1981 • 66 citations

The Molecular Biology of Nucleotide Excision Repair of DNA: Recent Progress

1987 • 65 citations

Defective thymine dimer excision from xeroderma pigmentosum chromatin and its characteristic catalysis by cell-free extracts

1983 • 61 citations

Cross-sensitivity to topoisomerase II inhibitors in cytotoxic drug-hypersensitive Chinese hamster ovary cell lines.

1987 • 52 citations

Specificity and completeness of inhibition of DNA repair by novobiocin and aphidicolin

1982 • 49 citations

Molecular Studies on the Nature of the Repair Defect in Ataxia-Telangiectasia and Their Implications for Cellular Radiobiology

1987 • 48 citations

Effect of gyrB-mediated changes in chromosome structure on killing of Escherichia coli by ultraviolet light: experiments with strains differing in deoxyribonucleic acid repair capacity

1981 • 47 citations

Requirement of ATP for specific incision of ultraviolet-damaged DNA during excision repair in permeable human fibroblasts.

1983 • 46 citations

Predominant role for DNA damage in etoposide-induced cytotoxicity and cell cycle perturbation in human SV40-transformed fibroblasts.

1986 • 45 citations

Distribution of u.v.-induced repair events in higher-order chromatin loops in human and hamster fibroblasts

1986 • 43 citations

Cell cycle‐related variations in UV damage and repair capacity in chinese hamster (CHO‐K1) cells

1980 • 39 citations

ts A1S9 locus in mouse L cells may encode a novobiocin binding protein that is required for DNA topoisomerase II activity.

1983 • 38 citations

Repair and survival after UV in quiescent and proliferating Microtus agrestis cells: Different rates of incision and different dependence on DNA precursor supply

1979 • 35 citations

Novobiocin inhibits passive chromatin assembly in vitro.

1986 • 34 citations

Coumermycin A₁: a preferential inhibitor of replicative DNA synthesis in Escherichia coli. II. In vitro characterization

1976 • 33 citations

Selective inhibition of semiconservative DNA synthesis by nalidixic acid in permeabilized bacteria

1974 • 32 citations

Short Communication: The involvement of DNA topoisomerases in DNA repair and mutagenesis

1981 • 31 citations

The effect of various inhibitors of DNA synthesis on the repair of DNA photoproducts

1983 • 27 citations

Relationship of DNA Tertiary and Quaternary Structure to Carcinogenic Processes

1982 • 25 citations

Direct inhibition of u.v.-induced DNA excision repair in human cells by novobiocin, coumermycin and nalidixic acid

1987 • 25 citations

Loss of DNA Topoisomerase I Activity Alters Many Cellular Functions in Salmonella typhimurium

1983 • 25 citations

Effect of the bacterial DNA gyrase inhibitors, novobiocin, nalidixic acid, and oxolinic acid, on oxidative phosphorylation.

1986 • 24 citations

Action of etoposide (VP-16-123) on human cells: no evidence for topoisomerase II involvement in excision repair of u.v.-induced DNA damage, nor for mitochondrial hypersensitivity in ataxia telangiectasia

1987 • 19 citations

Visualization of chromatin events during DNA excision repair in XP cells: deficiency in localized but not generalized chromatin events

1986 • 19 citations

Reparative strand incision in saponin-permeabilized human fibroblasts

1987 • 18 citations

IS DNA TOPOISOMERASE INVOLVED IN THE UV EXCISION REPAIR PROCESS? NEW EVIDENCE FROM STUDIES WITH DNA INTERCALATING AND NON‐INTERCALATING ANTITUMOR AGENTS

1987 • 18 citations

Evidence that novobiocin and nalidixic acid do not inhibit excision repair in u.v.-irradiated human skin fibroblasts at a pre-incision step

1985 • 18 citations

Effects of Caffeine on Chromosomes in Cells of Higher Eukaryotic Organisms

1987 • 17 citations

The DNA of UV-irradiated normal and excision-deficient mammalian cells undergoes relaxation in an initial stage of DNA repair

1986 • 15 citations

Excision repair: our current knowledge based on human (xeroderma pigmentosum) and cattle cells.

1972 • 14 citations

Correlations of DNA damage and repair with nuclear and chromosomal damage in HeLa cells caused by methylnitrosamides.

1981 • 13 citations

Effect of novobiocin on the frequencies of chromatid-type aberrations and sister-chromatid exchanges following γ-irradiation

1985 • 12 citations

The application of soil mechanics to spouted bed design

1974 • 12 citations

Novobiocin does not inhibit DNA repair in an activve gene

1986 • 11 citations

Dominant mutation in mouse cells associated with resistance to Hoechst 33258 dye, but sensitivity to ultraviolet light and DNA base-damaging compounds

1987 • 10 citations

Isolation and characterization of novobiocin-resistant BHK cells

1987 • 8 citations

Pyrimidine dimers in Drosophila chromatin become increasingly accessible after irradiation

1987 • 8 citations

Enhanced Resistance to Nitrosoguanidine Killing and Mutagenesis in a DNA Gyrase Mutant of Escherichia coli

1982 • 7 citations

Failure of the intercalating agent 4′-(9-acridylamino)-methanesulphon-m-anisidide to induce DNA-repair replication in cultured human cells

1983 • 6 citations

Characterisation of Nuclear and Cytoplasmic DNA Polymerases From Rat Intestinal Mucosa

1974 • 5 citations

Dna topoisomerase ii in mammalian cells could be a target of caffeine c and 8 methoxycaffeine 8mc

1986 • 3 citations