The fiftieth anniversary of hypoglycaemic sulphonamides. How did the mother compound work?

Opposite effects of tolbutamide and diazoxide on the ATP-dependent K+ channel in mouse pancreatic ?-cells

1986 • 572 citations

Regulation of insulin secretion studied with pieces of rabbit pancreas incubated in vitro

1964 • 540 citations

Glucose dependent K+-channels in pancreatic?-cells are regulated by intracellular ATP

1985 • 388 citations

Significance of ionic fluxes and changes in membrane potential for stimulus-secretion coupling in pancreatic B-cells

1984 • 324 citations

Membrane potential of beta-cells in pancreatic islets

1974 • 295 citations

A metabolite-regulated potassium channel in rat pancreatic B cells.

1986 • 277 citations

New Antidiabetic Drugs

1990 • 213 citations

Comparison of Plasma Insulin Levels Following Administration of Tolbutamide and Glucose

1960 • 212 citations

Potassium channels: structure, classification, function and therapeutic potential

1991 • 201 citations

Opposite effects of tolbutamide and diazoxide on 86Rb+ fluxes and membrane potential in pancreatic B cells

1982 • 179 citations

Ultrastructural Changes in Islets of the Rat Produced by Tolbutamide

1961 • 174 citations

Ein neues antidiabetisches Prinzip

1955 • 169 citations

Opposite effects of intracellular Ca2+ and glucose on K+ permeability of pancreatic islet cells

1979 • 101 citations

Über ein wirksames perorales Antidiabeticum (BZ 55)

1955 • 100 citations

Über eine neue blutzuckersenkende Substanz

1955 • 99 citations

CLINICAL AND EXPERIMENTAL STUDIES OF INSULIN SECRETION FOLLOWING TOLBUTAMIDE AND METAHEXAMIDE ADMINISTRATION

1959 • 94 citations

An in vitro method for studying insulin secretion in the perfused isolated rat pancreas

1966 • 93 citations

Mechanisms of Sulfonylurea-lnduced Insulin Release

1990 • 76 citations

Étude Physiologique et Pharmacodynamique de Certains Dérivés Sulfamidés Hypoglycémiants

1946 • 62 citations

Über die orale Behandlung des Diabetes mellitus mit N-[4-Methyl-benzolsulfonyl]-N'-butyl-harnstoff (D 860) Klinische und experimentelle Untersuchungen.

1956 • 60 citations

Insulin Secretion Following Carbutamide Injections in Normal Dogs.

1956 • 46 citations

Clonidine inhibits ATP‐sensitive K⁺channels in mouse pancreatic β‐cells

1991 • 43 citations

Intrapancreatic perfusion of the antidiabetic sulfonylureas.

1956 • 43 citations

TOLBUTAMIDE CONTROL OF DIABETES MELLITUS

1959 • 41 citations

Vergleichende Untersuchungen von Morphologie und Hormongehalt des Kälberpankreas nach Sulfonylharnstoffen (D 860)

1957 • 40 citations

Chemische Ausschaltung der A-Zellen derLangerhansschen Inseln

1954 • 40 citations

Vanadate stimulation of insulin release in normal mouse islets.

1991 • 37 citations

Characterization and Significance of Sulfonylurea Receptors

1990 • 37 citations

Versuche und Untersuchungen mit Neuen Sulfonamiden

1941 • 36 citations

Hypoglycemic Action of Sulfanilamido-cyclopropylthiazole in Rabbits, and Its Reversal by Alloxan

1946 • 34 citations

Sulfonylurea Signal Transduction

1991 • 31 citations

Effect of Garbutamide on the Insulin Content of the Dog Pancreas

1957 • 28 citations

Effects of sulfonylureas upon insulin secretion by the rat's pancreas

1967 • 26 citations

Stimulation by carbutamide and tolbutamide of insulin release from rat pancreas in vitro.

1961 • 23 citations

Carbutamide and Plasma Insulin Activity

1957 • 23 citations

RESEARCHES ON INSULIN I. IS INSULIN AN UNSTABLE SULPHUR COMPOUND

1925 • 21 citations

�ber neue peroral wirksame blutzuckersenkende Substanzen

1956 • 21 citations

Die Insulinsekretion des Pankreas bei extracorporaler Perfusion

1962 • 20 citations

Symposium on clinical and experimental effects of sulfonylureas in diabetes mellitus; editorial statement.

1956 • 19 citations

[A new highly-active oral antidiabetic].

1966 • 19 citations

Die Insulinsekretion des Pankreas bei extracorporaler Perfusion

1962 • 13 citations

Chemische Ausschaltung der A-Zellen der Langerhansschen Inseln

1954 • 12 citations

[Blood sugar and histological changes in normal rabbits after administration of D-860].

1956 • 11 citations

Bemerkung zu den Arbeiten über N₁-sulfanilyl-N₂-n-butylcarbamid als perorales Antidiabetikum

1956 • 10 citations

Untersuchungen zum Wirkungsmechanismus der Sulfonylharnstoffe

1960 • 10 citations

[Experimental study of the effect of BZ 55 on normal and alloxan-treated rats; morphological changes, especially pancreatic changes].

1956 • 7 citations

Hypoglykämische Wirkung des Schwefels

1926 • 7 citations

THE EFFECT OF HUMAN PLASMA ON THE GLUCOSE UPTAKE OF THE RAT DIAPHRAGM BEFORE AND AFTER ADMINISTRATION OF CARBUTAMIDE

1957 • 6 citations

Wirkung peroraler Schwefelzufuhr auf die diabetische Stoffwechselstörung

1927 • 5 citations

Present State of Knowledge Concerning Effects of the Sulfonylurea Compounds in Diabetes Mellitus: Report of the Committee on Summarization of the Conference

1957 • 4 citations

[Effects of p-aminobenzene-sulfamido-isopropylthiodiazol on glycemia, on the structure of the islands of Langerhans and on the metabolism of normal or diabetic animals].

1955 • 2 citations

Experimental study of a hypoglycaemic sulfonamide. I. Morphological, and in particular pancreatic, modifications brought about in normal rats and diabetic rats by R.P. 2 254.

1955 • 2 citations

[Paraaminobenzene-sulfonamido-isopropyl-thiadiazol in the treatment of diabetes mellitus; clinical aspects and attempt to interpret the mechanism of the drug].

1956 • 1 citations

[Curative action of 2-isopropyl-5-sulfanilamido-1, 3, 4-thiadiazole on human diabetes mellitus].

1955 • 1 citations

About the hypoglycaemic action of certain sulfonamide derivatives.

1948 • 1 citations

[Trial treatment of diabetes mellitus in adults with synthetic hypoglycemic agents of the sulfamido-thiodiazol series (2254 and 2261 RP)].

1956 • 1 citations

Deleted Work

1955 • 0 citations