Inhibition of the Tumor Necrosis Factor-α Pathway Is Radioprotective for the Lung

ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

1996 • 2,527 citations

Cytokine Pathways and Joint Inflammation in Rheumatoid Arthritis

2001 • 2,229 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

Phase III Randomized Trial of Amifostine as a Radioprotector in Head and Neck Cancer

2000 • 809 citations

Identification of Novel TGF-β/Smad Gene Targets in Dermal Fibroblasts using a Combined cDNA Microarray/Promoter Transactivation Approach

2001 • 628 citations

Early Growth Response Gene 1–mediated Apoptosis Is Essential for Transforming Growth Factor β1–induced Pulmonary Fibrosis

2004 • 352 citations

Identification of Novel Inhibitors of the Transforming Growth Factor β1 (TGF-β1) Type 1 Receptor (ALK5)

2002 • 306 citations

Dose-dependent induction of transforming growth factor β (TGF-β) in the lung tissue of fibrosis-prone mice after thoracic irradiation

2000 • 267 citations

Randomized Trial of Amifostine in Locally Advanced Non–Small-Cell Lung Cancer Patients Receiving Chemotherapy and Hyperfractionated Radiation: Radiation Therapy Oncology Group Trial 98-01

2005 • 223 citations

Transient Transgene Expression of Decorin in the Lung Reduces the Fibrotic Response to Bleomycin

2001 • 184 citations

Interaction of Smad3 with a proximal smad-binding element of the human ?2(I) procollagen gene promoter required for transcriptional activation by TGF-?

2000 • 180 citations

Early and persistent alterations in the expression of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor alpha mRNA levels in fibrosis-resistant and sensitive mice after thoracic irradiation.

1996 • 175 citations

Radiation-Induced Pulmonary Fibrosis: Examination of Chemokine and Chemokine Receptor Families

2002 • 174 citations

Early and Persistent Alterations in the Expression of Interleukin-1α, Interleukin-1β and Tumor Necrosis Factor α mRNA Levels in Fibrosis-Resistant and Sensitive Mice after Thoracic Irradiation

1996 • 156 citations

Glucose Withdrawal Induces Oxidative Stress followed by Apoptosis in Glioblastoma Cells but not in Normal Human Astrocytes

2006 • 139 citations

Fibroblast-specific Expression of a Kinase-deficient Type II Transforming Growth Factor β (TGFβ) Receptor Leads to Paradoxical Activation of TGFβ Signaling Pathways with Fibrosis in Transgenic Mice

2003 • 135 citations

Manganese Superoxide Dismutase (SOD2) Inhibits Radiation-Induced Apoptosis by Stabilization of the Mitochondrial Membrane

2002 • 130 citations

Etanercept (Enbrel) administration for idiopathic pneumonia syndrome after allogeneic hematopoietic stem cell transplantation

2002 • 127 citations

Modulation of Radiation-Induced Cytokine Elevation Associated with Esophagitis and Esophageal Stricture by Manganese Superoxide Dismutase-Plasmid/Liposome (SOD2-PL) Gene Therapy

2001 • 124 citations

Regulation of Hepatic Glutathione Synthesis

1998 • 123 citations

Immunohistochemical Localization of Transforming Growth Factor β and Tumor Necrosis Factor α in the Lungs of Fibrosis-Prone and "Non-Fibrosing" Mice during the Latent Period and Early Phase after Irradiation

1997 • 120 citations

Transgenic Modeling of Transforming Growth Factor- 1: Role of Apoptosis in Fibrosis and Alveolar Remodeling

2006 • 117 citations

The role of cytokines in the development of normal-tissue reactions after radiotherapy.

1998 • 117 citations

Manganese [correction of Magnesium] superoxide dismutase (MnSOD) plasmid/liposome pulmonary radioprotective gene therapy: Modulation of irradiation-induced mRNA for IL-I, TNF-alpha, and TGF-beta correlates with delay of organizing alveolitis/fibrosis

1999 • 116 citations

The physical parameters and molecular events associated with radiation-induced lung toxicity

2000 • 114 citations

Eosinophils and T Lymphocytes Possess Distinct Roles in Bleomycin-Induced Lung Injury and Fibrosis

2003 • 106 citations

Prevention of Radiation-Induced Oral Cavity Mucositis by Plasmid/Liposome Delivery of the Human Manganese Superoxide Dismutase (SOD2) Transgene

2003 • 104 citations

A randomized study of very accelerated radiotherapy with and without amifostine in head and neck squamous cell carcinoma

2000 • 103 citations

Transforming growth factor-beta2 antibody attenuates fibrosis in the experimental diabetic rat kidney

2001 • 89 citations

Molecular mechanisms of tumor necrosis factor‐α‐mediated plasminogen activator inhibitor‐1 expression in adipocytes

2005 • 82 citations

Fibroblast radiosensitivity in vitro and lung fibrosis in vivo: comparison between a fibrosis-prone and fibrosis-resistant mouse strain.

1996 • 82 citations

The role of cytokines in human lung fibrosis.

1996 • 77 citations

Radioprotection of Normal Tissues against Gamma Rays and Cyclotron Neutrons with WR-2721: LD 50 Studies and 35 S-WR-2721 Biodistribution

1984 • 73 citations

Reduced Tumor Necrosis Factor-α and Transforming Growth Factor-β1 Expression in the Lungs of Inbred Mice that Fail to Develop Fibroproliferative Lesions Consequent to Asbestos Exposure

1999 • 66 citations

Cooperation between SMAD and NF-κB in growth factor regulated type VII collagen gene expression

1999 • 66 citations

Blockade of TGF-β by in vivo gene transfer of a soluble TGF-β type II receptor in the muscle inhibits corneal opacification, edema and angiogenesis

2000 • 66 citations

Fibroblast Radiosensitivity In Vitro and Lung Fibrosis In Vivo: Comparison between a Fibrosis-Prone and Fibrosis-Resistant Mouse Strain

1996 • 65 citations

The pulmonary effects of thoracic irradiation.

1994 • 64 citations

Effectiveness of tranilast on restenosis after directional coronary atherectomy

1997 • 64 citations

Potential role of apoptotic macrophages in pulmonary inflammation and fibrosis

2002 • 63 citations

The protective effect of recombinant human keratinocyte growth factor on radiation-induced pulmonary toxicity in rats

2004 • 53 citations

Cell phenotype specific kinetics of expression of intratracheally injected manganese superoxide dismutase–plasmid/liposomes (MnSOD–PL) during lung radioprotective gene therapy

2003 • 51 citations

Pulmonary toxicity after radiotherapy in primary breast cancer patients: results from a randomized chemotherapy study

2002 • 42 citations

Antisense TGF-?2 Immunotherapy for Hepatocellular Carcinoma: Treatment in a Rat Tumor Model

2001 • 41 citations

Antisense Oligonucleotide Inhibition of Tumor Necrosis Factor Receptor 1 Protects the Liver from Radiation-Induced Apoptosis

2006 • 38 citations

Lung damage following bone marrow transplantation after hyperfractionated total body irradiation

1991 • 35 citations

Transforming growth factor‐β and tumor necrosis factor‐α cooperate to induce apoptosis in the oligodendroglial cell line OLI‐neu

2003 • 17 citations

Tumour necrosis factor-α production in fibrosing alveolitis is macrophage subset specific

2001 • 17 citations

Amifostine in Chemoradiation Therapy for Non-Small Cell Lung Cancer: Review of Experience and Design of a Phase II Trial Assessing Subcutaneous and Intravenous Bolus Administration

2005 • 15 citations

Effects of radiation on the lung

1996 • 13 citations

Stellenwert der Strahlentherapie von Residualtumoren nach Chemotherapie metastasierter Seminome

1998 • 4 citations