“Action-at-a-Distance” Mutagenesis

Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

1991 • 2,172 citations

MISMATCH REPAIR IN REPLICATION FIDELITY, GENETIC RECOMBINATION, AND CANCER BIOLOGY

1996 • 1,485 citations

Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents

1984 • 941 citations

MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis

1992 • 875 citations

Requirement of mammalian DNA polymerase-β in base-excision repair

1996 • 820 citations

Mutagenesis by 8-oxoguanine: an enemy within

1993 • 805 citations

Misreading of DNA templates containing 8-hydroxydeoxyguanosine at the modified base and at adjacent residues

1987 • 778 citations

Urinary 8-hydroxy-2'-deoxyguanosine as a biological marker of in vivo oxidative DNA damage.

1989 • 733 citations

The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)

1992 • 688 citations

8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificity.

1991 • 678 citations

The MutT Proteins or “Nudix” Hydrolases, a Family of Versatile, Widely Distributed, “Housecleaning” Enzymes

1996 • 671 citations

Excision of Deoxyribose Phosphate Residues by DNA Polymerase β During DNA Repair

1995 • 670 citations

Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA.

1992 • 590 citations

DNA polymerase insertion fidelity. Gel assay for site-specific kinetics.

1987 • 332 citations

NMR structural studies of the ionizing radiation adduct 7-hydro-8-oxodeoxyguanosine (8-oxo-7H-dG) opposite deoxyadenosine in a DNA duplex. 8-Oxo-7H-dG(syn).cntdot.dA(anti) alignment at lesion site

1991 • 295 citations

Mammalian base excision repair and DNA polymerase beta

1998 • 275 citations

Short gap-filling synthesis by DNA polymerase beta is processive

1993 • 228 citations

Nucleotide insertion kinetics opposite abasic lesions in DNA.

1987 • 209 citations

NMR studies of a DNA containing 8-hydroxydeoxyguanosine

1991 • 209 citations

Evidence for an Imino Intermediate in the DNA Polymerase β Deoxyribose Phosphate Excision Reaction

1996 • 165 citations

Abasic Translesion Synthesis by DNA Polymerase β Violates the “A-rule”

1997 • 163 citations

Studies on the mutator gene, mutT of Escherichia coli. Molecular cloning of the gene, purification of the gene product, and identification of a novel nucleoside triphosphatase.

1988 • 130 citations

Expression of human DNA polymerase .beta. in Escherichia coli and characterization of the recombinant enzyme

1988 • 121 citations

A specific role of MutT protein: to prevent dG.dA mispairing in DNA replication.

1989 • 120 citations

Increased Activity and Fidelity of DNA Polymerase β on Single-nucleotide Gapped DNA

1997 • 104 citations

Characterization of the mutT nucleoside triphosphatase of Escherichia coli

1991 • 99 citations

Catalytic subunit of human DNA polymerase alpha overproduced from baculovirus-infected insect cells. Structural and enzymological characterization.

1991 • 71 citations

Oxygen radical induced mutagenesis is DNA polymerase specific

1994 • 56 citations

In search of a mutational hotspot

1998 • 49 citations

Replication of Template-Primers Containing Propanodeoxyguanosine by DNA Polymerase β

1997 • 42 citations

Synthesis and Thermodynamic Stabilities of Damaged DNA Involving 8-Hydroxyguanine (7,8-Dihydro-8-Oxoguanine) in aras-Gene Fragments

1994 • 36 citations