Experimental Chemotherapy and Concepts Related to the Cell Cycle

The Clonal Evolution of Tumor Cell Populations

1976 • 6,310 citations

International Journal of Radiation Biology

1959 • 1,730 citations

Primary Bioassay of Human Tumor Stem Cells

1977 • 1,625 citations

A mathematic model for relating the drug sensitivity of tumors to their spontaneous mutation rate.

1979 • 1,331 citations

The Kinetics of Cellular Proliferation

1960 • 948 citations

The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour

1968 • 764 citations

Oxygen Transport to Tissue

1973 • 701 citations

The genetic origin of drug resistance in neoplasms: implications for systemic therapy.

1984 • 521 citations

Use of Restriction Fragment Length Polymorphisms to Determine the Clonal Origin of Human Tumors

1985 • 387 citations

A Critical Appraisal of the Human Tumor Stem-Cell Assay

1983 • 365 citations

Differentiation of malignant to benign cells

1971 • 306 citations

Mutagenic activity of tumor-associated macrophages in Salmonella typhimurium strains TA98 and TA 100.

1984 • 302 citations

Organ Selectivity for Implantation Survival and Growth of B16 Melanoma Variant Tumor Lines 2

1976 • 297 citations

Gene amplification, drug resistance, and cancer.

1984 • 284 citations

Population kinetics of carcinoma cells, capillary endothelial cells, and fibroblasts in a transplanted mouse mammary tumor.

1970 • 243 citations

Resistance to adriamycin in multicellular spheroids

1979 • 227 citations

Cell kinetics and chemotherapy: a critical review.

1978 • 224 citations

The Origin and Development of Human Tumors Studied with Cell Markers

1974 • 208 citations

A Stem Cell Model of Human Tumor Growth: Implications for Tumor Cell Clonogenic Assays<xref ref-type="fn" rid="FN2">2</xref>

1983 • 190 citations

Limited penetration of methotrexate into human osteosarcoma spheroids as a proposed model for solid tumor resistance to adjuvant chemotherapy.

1980 • 155 citations

Dynamic Heterogeneity: Rapid Generation of Metastatic Variants in Mouse B16 Melanoma Cells

1984 • 150 citations

TUMOUR CELL PROLIFERATION IN RELATION TO THE VASCULATURE

1979 • 143 citations

Journal of the national cancer institute

1993 • 136 citations

Proliferative state of blast cell progenitors in acute myeloblastic leukemia (AML)

1978 • 127 citations

Oxygen Diffusion Distance and Development of Necrosis in Multicell Spheroids

1979 • 121 citations

Tumor-selective modification of cellular microenvironment in vivo: effect of glucose infusion on the pH in normal and malignant rat tissues.

1982 • 120 citations

Cell selection from a murine tumour using the fluorescent probe Hoechst 33342

1985 • 120 citations

Cell and Tissue Kinetics

2014 • 107 citations

Cell Cycles in Cell Hierarchies

1986 • 98 citations

Differential effects of cytotoxic agents on hematopoietic progenitors.

1981 • 86 citations

Response of aerobic and hypoxic cells in a solid tumor to adriamycin and cyclophosphamide and interaction of the drugs with radiation.

1982 • 86 citations

The response of hypoxic B16 melanoma cells to in vivo treatment with chemotherapeutic agents.

1975 • 82 citations

Cell cycle distribution of chronically hypoxic cells and determination of the clonogenic potential of cells accumulated in G2 + M phases after irradiation of a solid tumor in vivo.

1979 • 81 citations

Penetration and binding of vinblastine and 5-fluorouracil in cellular spheroids

1984 • 78 citations

Multisystem stem cell failure after apparent recovery from alkylating agents.

1978 • 78 citations

Proliferative state of human pluripotent hemopoietic progenitors (CFU- GEMM) in normal individuals and under regenerative conditions after bone marrow transplantation

1979 • 75 citations

In vitro short-term test to determine the resistance of human tumors to chemotherapy

1981 • 68 citations

Drug and Hormone Resistance in Neoplasia

2019 • 63 citations

In vitro and in vivo radiosensitivity of human tumour cells obtained from a pancreatic carcinoma xenograft

1976 • 62 citations

Colonial Growth in Agar ofcells Derived from Neoplastic and Non-Neoplastic Tissues of Children

1968 • 59 citations

The Proliferative Status And Clonogenic Capacity Of Tumour Cells In A Transplantable Rhabdomyosarcoma Of The Rat Before And After Irradiation With 800 Rad Of X‐Rays

1978 • 55 citations

Separation of cells from mouse solid tumors by centrifugal elutriation.

1977 • 51 citations

In Vitro Methods to Predict for Patient Response to Chemotherapy

1980 • 49 citations

Biologic discussions augmenting radiation effects and model systems

1975 • 47 citations

Evidence for a Major Role of Glucose in Controlling Developmnet of Necrosis in EMT6/RO Multicell, Tumor Spheroids

1983 • 37 citations

H+ transport and the regulation of intracellular pH in ehrlich ascites tumor cells

1984 • 31 citations

Radiobiological hypoxia of a transplanted rat tumour and the effect of treatment with cyclophosphamide

1978 • 23 citations

Proliferative state and radiosensitivity of human myeloma stem cells

1982 • 20 citations

The radiation response of human bladder cancer assessed in vitro or as xenografts in immune-deprived mice

1984 • 13 citations

Recent results of in vitro drug prediction in human tumour chemotherapy.

1978 • 6 citations

Lack of prognostic value of the thymidine-labelling index in adult acute leukaemia

1981 • 4 citations

Radiation Therapy

1985 • 1 citations