Anxiogenic effects in benzodiazepine withdrawal are linked to the development of tolerance

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

1985 • 5,596 citations

Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: A novel test of anxiety in the rat

1986 • 1,509 citations

The use of social interaction as a method for detecting anxiolytic activity of chlordiazepoxide-like drugs

1980 • 813 citations

Withdrawal reactions from chlordiazepoxide (?Librium?)

1961 • 340 citations

Tryptophan-5-hydroxylase: function and control.

1974 • 237 citations

Increase of ?antianxiety? activity and tolerance of behavioral depression during chronic administration of oxazepam

1968 • 232 citations

Chlordiazepoxide loses its anxiolytic action with long-term treatment

1979 • 107 citations

Tolerance to the benzodiazepine diazepam in an animal model of anxiolytic activity

1985 • 86 citations

The biological basis of benzodiazepine dependence

1987 • 59 citations

Mechanisms of action of benzodiazepines

1990 • 55 citations

Anxiogenic aspects of diazepam withdrawal can be detected in animals

1983 • 54 citations

Dependence liability of the benzodiazepines

1984 • 39 citations

Modification of depressant and disinhibitory action of flurazepam during short term treatment in the rat

1972 • 32 citations

Benzodiazepine effects upon Geller-Seifter conflict test in rats: Analysis of individual variability

1982 • 25 citations

Lack of tolerance development to benzodiazepines in antagonism of the pentylenetetrazol discriminative stimulus

1979 • 23 citations