Long-duration intracavitary infusion of methotrexate with systemic leucovorin protection in patients with malignant effusions.

Pharmacokinetic rationale for peritoneal drug administration in the treatment of ovarian cancer.

1978 • 707 citations

Carrier-mediated Transport of the Folic Acid Analogue, Methotrexate, in the L1210 Leukemia Cell

1968 • 384 citations

Neurotoxicity and Elevated Cerebrospinal-Fluid Methotrexate Concentration in Meningeal Leukemia

1973 • 341 citations

THE CHARACTERISTICS OF THE MEMBRANE TRANSPORT OF AMETHOPTERIN AND THE NATURALLY OCCURRING FOLATES

1971 • 291 citations

The effect of organic acids on renal clearance of methotrexate in man

1969 • 267 citations

Phase I and pharmacological studies of 5-fluorouracil administered intraperitoneally.

1980 • 249 citations

Experimental evaluation of potential anticancer agents. XXI. Scheduling of arabinosylcytosine to take advantage of its S-phase specificity against leukemia cells.

1967 • 242 citations

Dose schedule and antitumor studies of arabinosyl cytosine (NSC 63878).

1969 • 216 citations

Growth Rate Patterns of Solid Tumors and Their Relation to Responsiveness to Therapy

1978 • 195 citations

Control of the Initiation of DNA Synthesis in 3T3 Cells: Low-Molecular-Weight Nutrients

1974 • 170 citations

The reversal of methotrexate cytotoxicity to mouse bone marrow cells by leucovorin and nucleosides.

1976 • 163 citations

"Concentration x time" methotrexate via a subcutaneous reservoir: a less toxic regimen for intraventricular chemotherapy of central nervous system neoplasms

1978 • 149 citations

Methotrexate toxicity: Correlation with duration of administration, plasma levels, dose and excretion pattern

1972 • 136 citations

High volume intraperitoneal chemotherapy (?Belly bath?) for ovarian cancer

1978 • 107 citations

"Rescue" techniques in cancer chemotherapy: use of leucovorin and other rescue agents after methotrexate treatment.

1977 • 107 citations

Clinical pharmacology of intrathecal methotrexate. I. Pharmacokinetics in nontoxic patients after lumbar injection.

1977 • 97 citations

Optimization of high-dose methotrexate with leucovorin rescue therapy in the L1210 leukemia and sarcoma 180 murine tumor models.

1978 • 84 citations

Role of drug concentration, duration of exposure, and endogenous metabolites in determining methotrexate cytotoxicity.

1977 • 76 citations

Studies relating to the mode of action of methotrexate. II. Studies on sites of action in L-cells in vitro.

1969 • 72 citations

S-phase cells of rapidly growing and resting populations. Differences in response to methotrexate.

1969 • 70 citations

Effect of Sodium Salicylate and Indomethacin on Methotrexate-Serum Albumin Binding

1977 • 53 citations

NEW APPROACHES TO CHEMOTHERAPY WITH FOLATE ANTAGONISTS: USE OF LEUCOVORIN “RESCUE” AND ENZYMIC FOLATE DEPLETION*

1971 • 49 citations

Measurement of cellular DNA mass by flow microfluorometry with use of a biological internal standard.

1978 • 48 citations

Selective antagonism of 5-fluorouracil cytotoxicity by 4-hydroxypyrazolopyrimidine (allopurinol) in vitro.

1979 • 44 citations

Analysis of the cycling and noncycling cell population of human solid tumors

1977 • 37 citations

Serum distribution of citrovorum factor and 5-methyltetrahydrofolate following oral and im administration of calcium leucovorin in normal adults.

1978 • 35 citations

Thymidine requirements for the rescue of patients treated with high-dose methotrexate.

1980 • 33 citations

Effect of methotrexate concentration and exposure time on mammalian cell survival in vitro

1980 • 30 citations

Cell cycle parameters in human solid tumors

1977 • 29 citations

Resistance of resting 3T6 mouse fibroblasts to methotrexate cytotoxicity.

1978 • 27 citations

Cytokinetic comparison of thymidine and leucovorin rescue of marrow in humans after exposure to high-dose methotrexate.

1979 • 26 citations

Allopurinol modulation of high-dose fluorouracil toxicity

1979 • 24 citations

Drug-induced changes in DNA fluorescence intensity detected by flow microfluorometry and their implications for analysis of DNA content distributions.

1978 • 21 citations

Thymidine as a Chemotherapeutic Agent: Pharmacologic, Cytokinetic, and Biochemical Studies in a Patient With T-Cell Acute Lymphocytic Leukemia<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1980 • 16 citations

Rescue of human lymphoid cells from the effects of methotrexate in vitro.

1978 • 14 citations

Effect of sodium salicylate and indomethacin on methotrexate-serum albumin binding

1977 • 12 citations

A comparison of the biological effects of dichloromethotrexate and methotrexate on human leukemic cells in culture.

1979 • 9 citations

Reversal of the in vitro methotrexate suppression of cell-mediated immune response by folinic acid and thymidine plus hypoxanthine.

1980 • 7 citations

Biochemical and pharmacokinetic effect of leucovorin during high-dose methotrexate therapy in murine tumor models. Abstr.

1976 • 2 citations