Characterization of the H-kininogen-binding Site on Factor XI

Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension

1989 • 3,067 citations

The coagulation cascade: initiation, maintenance, and regulation

1991 • 1,810 citations

The molecular basis of blood coagulation

1988 • 1,240 citations

Factor XI Activation in a Revised Model of Blood Coagulation

1991 • 774 citations

High Levels of Coagulation Factor XI as a Risk Factor for Venous Thrombosis

2000 • 670 citations

Contact System: A Vascular Biology Modulator With Anticoagulant, Profibrinolytic, Antiadhesive, and Proinflammatory Attributes

1997 • 577 citations

COFACTOR PROTEINS IN THE ASSEMBLY AND EXPRESSION OF BLOOD CLOTTING ENZYME COMPLEXES

1988 • 535 citations

Identification of prekallikrein and high-molecular-weight kininogen as a complex in human plasma.

1976 • 350 citations

Differences in the properties and enzymatic specificities of the two active sites of angiotensin I-converting enzyme (kininase II). Studies with bradykinin and other natural peptides

1993 • 321 citations

Amino acid sequence of human factor XI, a blood coagulation factor with four tandem repeats that are highly homologous with plasma prekallikrein

1986 • 258 citations

Human plasma prekallikrein, a zymogen to a serine protease that contains four tandem repeats

1986 • 220 citations

Factor IX is activated in vivo by the tissue factor mechanism

1990 • 213 citations

Isolation and Characterization of the Kininogen-binding Protein p33 from Endothelial Cells

1996 • 210 citations

Organization of the gene for human factor XI

1987 • 147 citations

Inactivation of factor XIa in human plasma assessed by measuring factor XIa-protease inhibitor complexes: major role for C1-inhibitor

1995 • 144 citations

Location of the disulfide bonds in human coagulation factor XI: the presence of tandem apple domains

1991 • 139 citations

Assembly of contact-phase factors on the surface of the human neutrophil membrane

1994 • 132 citations

Primary structure requirements for the binding of human high molecular weight kininogen to plasma prekallikrein and factor XI.

1987 • 125 citations

High Molecular Weight Kininogen Utilizes Heparan Sulfate Proteoglycans for Accumulation on Endothelial Cells

2000 • 112 citations

Binding of coagulation factor XI to washed human platelets

1986 • 108 citations

Prothrombin Is a Cofactor for the Binding of Factor XI to the Platelet Surface and for Platelet-Mediated Factor XI Activation by Thrombin

1998 • 105 citations

Identification of a Factor IX Binding Site on the Third Apple Domain of Activated Factor XI

1996 • 103 citations

Thrombin-mediated Feedback Activation of Factor XI on the Activated Platelet Surface Is Preferred over Contact Activation by Factor XIIa or Factor XIa

2000 • 90 citations

Apple four in human blood coagulation factor XI mediates dimer formation

1992 • 88 citations

Location of the disulfide bonds in human plasma prekallikrein: the presence of four novel apple domains in the amino-terminal portion of the molecule

1991 • 84 citations

A Binding Site for Heparin in the Apple 3 Domain of Factor XI

1998 • 82 citations

Identification of the binding site for plasma prekallikrein in human high molecular weight kininogen. A region from residues 185 to 224 of the kininogen light chain retains full binding activity.

1986 • 80 citations

Model for a factor IX activation complex on blood platelets: dimeric conformation of factor XIa is essential

2001 • 77 citations

Gene structure and chromosomal localization of plasma kallikrein

1991 • 74 citations

Identification and chemical synthesis of a substrate-binding site for factor IX on coagulation factor XIa.

1991 • 71 citations

Identification of Amino Acids in the Factor XI Apple 3 Domain Required for Activation of Factor IX

1999 • 70 citations

Six point mutations that cause factor XI deficiency

1995 • 70 citations

Identification and Characterization of a Binding Site for Platelets in the Apple 3 Domain of Coagulation Factor XI

1995 • 67 citations

Factor XI antigen and activity in human platelets

1982 • 67 citations

Human Platelets and Factor XI

1979 • 65 citations

Mapping of the Discontinuous H-kininogen Binding Site of Plasma Prekallikrein

1999 • 58 citations

Effect of cleavage of the heavy chain of human plasma kallikrein on its functional properties

1985 • 58 citations

Localization of the high molecular weight kininogen binding site in the heavy chain of human factor XI to amino acids phenylalanine 56 through serine 86.

1990 • 55 citations

Effect of cleavage of the heavy chain of human plasma kallikrein on its functional properties

1985 • 51 citations

Molecular Cloning of Platelet Factor XI, an Alternative Splicing Product of the Plasma Factor XI Gene

1998 • 45 citations

Fine mapping of the high molecular weight kininogen binding site on blood coagulation factor XI through the use of rationally designed synthetic analogs.

1992 • 44 citations

Mapping of the Discontinuous Kininogen Binding Site of Prekallikrein

1996 • 44 citations

Dissemination of contact activation in plasma by plasma kallikrein.

1980 • 43 citations

The Role of High Molecular Weight Kininogen and Prothrombin as Cofactors in the Binding of Factor XI A3 Domain to the Platelet Surface

2000 • 40 citations

Factor XI Messenger RNA in Human Platelets

1999 • 39 citations

Cell surface‐associated chondroitin sulfate proteoglycans bind contact phase factor H‐kininogen

2001 • 37 citations

Immunologic studies of human coagulation factor XI and its complex with high molecular weight kininogen

1983 • 36 citations

High molecular weight kininogen-binding site of prekallikrein probed by monoclonal antibodies.

1990 • 35 citations

Fibrin Affinity and Clearance of t-PA Deletion and Substitution Analogues

1990 • 33 citations

Tissue-Specific Expression of Functional Platelet Factor XI Is Independent of Plasma Factor XI Expression

1998 • 31 citations

Mapping of the high molecular weight kininogen binding site of prekallikrein. Evidence for a discontinuous epitope formed by distinct segments of the prekallikrein heavy chain

1993 • 26 citations

Functional domains in the heavy-chain region of factor XI: a high molecular weight kininogen-binding site and a substrate-binding site for factor IX

1989 • 26 citations

Localization of the Binding Site on Plasma Kallikrein for High-Molecular-Weight Kininogen to Both Apple 1 and Apple 4 Domains of the Heavy Chain

1994 • 22 citations