Clozapine and olanzapine exhibit an intrinsic anxiolytic property in two conditioned fear paradigms: Contrast with haloperidol and chlordiazepoxide

Antipsychotic Dosing in Preclinical Models Is Often Unrepresentative of the Clinical Condition: A Suggested Solution Based on in Vivo Occupancy

2003 • 464 citations

Different lateral amygdala outputs mediate reactions and actions elicited by a fear-arousing stimulus

2000 • 371 citations

Neurochemical dissociation of memory systems

1987 • 286 citations

The behavioral pharmacology of olanzapine, a novel "atypical" antipsychotic agent.

1992 • 264 citations

Conditioned Fear‐Induced Opiate Analgesia: A Competing Motivational State Theory of Stress Analgesia^a

1986 • 238 citations

Pharmacological Specificity of Conditioned Avoidance Response Inhibition in Rats: Inhibition by Neuroleptics and Correlation to Dopamine Receptor Blockade

1982 • 238 citations

The anxiolytic-like effects of the neurosteroid allopregnanolone: interactions with GABAA receptors

1997 • 233 citations

Stress-induced hyperthermia and anxiety: pharmacological validation

2003 • 203 citations

Olanzapine

2001 • 202 citations

The conditioned avoidance response test re-evaluated: is it a sensitive test for the detection of potentially atypical antipsychotics?

1999 • 186 citations

The amygdala mediates the anxiolytic-like effect of the neurosteroid allopregnanolone in rat

1999 • 182 citations

Shock-induced ultrasonic vocalization in young adult rats: a model for testing putative anti-anxiety drugs

1993 • 178 citations

Overt behavior and ultrasonic vocalization in a fear conditioning paradigm: A dose–response study in the rat

2005 • 170 citations

Stress-induced vocalisation in adult animals. A valid model of anxiety?

2003 • 160 citations

Lurasidone (SM-13496), a novel atypical antipsychotic drug, reverses MK-801-induced impairment of learning and memory in the rat passive-avoidance test

2007 • 159 citations

Inhibition of amygdaloid dopamine D2 receptors impairs emotional learning measured with fear-potentiated startle

2001 • 158 citations

Discriminative fear conditioning to context expressed by multiple measures of fear in the rat

1999 • 153 citations

The use of conditioned suppression to evaluate the nature of neuroleptic-induced avoidance deficits.

1980 • 145 citations

The effects of intra-amygdaloid infusions of a D-sub-2 dopamine receptor antagonist on Pavlovian fear conditioning.

2000 • 144 citations

Olanzapine and Clozapine Increase the GABAergic Neuroactive Steroid Allopregnanolone in Rodents

2003 • 142 citations

Systemic blockade of D2-like dopamine receptors facilitates extinction of conditioned fear in mice

2005 • 131 citations

Conditioned ultrasonic distress vocalizations in adult male rats as a behavioural paradigm for screening anti-panic drugs

1995 • 121 citations

Evaluation of rat ultrasonic vocalizations as predictors of the conditioned aversive effects of drugs

2001 • 100 citations

Effects of typical and atypical antipsychotic drugs on freezing behavior induced by conditioned fear

1996 • 83 citations

Clozapine markedly elevates pregnenolone in rat hippocampus, cerebral cortex, and serum: Candidate mechanism for superior efficacy?

2006 • 80 citations

Olanzapine and fluoxetine administration and coadministration increase rat hippocampal pregnenolone, allopregnanolone and peripheral deoxycorticosterone: Implications for therapeutic actions

2006 • 77 citations

Behavioural effects of chronic haloperidol and risperidone treatment in rats

2006 • 76 citations

Diazepam and gepirone selectively attenuate either 20–32 or 32–64 kHz ultrasonic vocalizations during aggressive encounters

1993 • 74 citations

Diazepam and memory: Evidence for spared memory function

1987 • 73 citations

Time Course of the Antipsychotic Effect and the Underlying Behavioral Mechanisms

2006 • 67 citations

Effects of haloperidol, sulpiride and SCH 23390 on passive avoidance learning in mice

1988 • 67 citations

Behavioral studies with anxiolytic drugs. V. Behavioral and in vivo neurochemical analyses in pigeons of drugs that increase punished responding.

1988 • 66 citations

Effects of benzodiazepines on passive avoidance response and latent learning in mice: relationship to benzodiazepine receptors and the cholinergic neuronal system.

1990 • 65 citations

Steroid Regulation of the GABA _A Receptor: Ligand Binding, Chloride Transport and Behaviour

2007 • 63 citations

Anxiolytic drugs and the acquisition of conditioned fear in mice

1985 • 57 citations

Anxiolytic effects of dopamine receptor ligands: I. involvement of dopamine autoreceptors

1998 • 57 citations

Effects of amphetamine and haloperidol on avoidance behavior and exploratory activity

1978 • 57 citations

Anxiolytic potential of sulpiride, clozapine and derivatives in the open-field test

1990 • 54 citations

A comparison of the effects of scopolamine and diazepam on acquisition and retention of inhibitory avoidance in mice

1990 • 52 citations

Antagonism by SCH 23390 of clozapine-induced hypothermia in the rat

1994 • 50 citations

Dopamine D4 receptor and anxiety: Behavioural profiles of clozapine, L-745,870 and L-741,742 in the mouse plus-maze

1997 • 49 citations

Pharmacological distinctions between ?active? and ?passive? avoidance memory formation as shown by manipulation of biogenic amine active compounds

1974 • 49 citations

Effects of four antipsychotics on punished responding in rats

1993 • 42 citations

Effect of low doses of clozapine on behaviour of isolated and group-housed male mice in the elevated plus-maze test

2002 • 41 citations

Clozapine: An atypical neuroleptic

1990 • 41 citations

Evaluation of the motor initiation hypothesis of APD-induced conditioned avoidance decreases

2004 • 41 citations

Conditioned place aversion produced by FG 7142 is attenuated by haloperidol

1989 • 39 citations

Olanzapine’s effects to reduce fear and anxiety and enhance social interactions coincide with increased progestin concentrations of ovariectomized rats

2003 • 38 citations

The muscarinic receptor agonist BuTAC, a novel potential antipsychotic, does not impair learning and memory in mouse passive avoidance

2001 • 37 citations

Clozapine-induced potentiation of latent inhibition is due to its action in the conditioning stage: implications for the mechanism of action of antipsychotic drugs

1999 • 36 citations

Some effects of clozapine on punished responding by mice and squirrel monkeys.

1980 • 36 citations

Effects of 8-OH-DPAT and buspirone in a passive avoidance test and in the elevated plus-maze test in rats

1991 • 33 citations

Influence of chronic treatment with olanzapine, clozapine and scopolamine on performance of a learned 8-arm radial maze task in rats

2005 • 33 citations

Body Temperature as a Conditional Response Measure for Pavlovian Fear Conditioning

2000 • 33 citations

The neurosteroid pregnanolone prevents the anxiogenic-like effect of inescapable shock in the rat

2000 • 32 citations

Evaluation of Perospirone (SM-9018), a Novel Serotonin-2 and Dopamine-2 Receptor Antagonist, and Other Antipsychotics in the Conditioned Fear Stress-Induced Freezing Behavior Model in Rats

1996 • 30 citations

Drug development for anxiety disorders: new roles for atypical antipsychotics.

2004 • 28 citations

Similar effects of diazepam and the 5-HT3 receptor antagonist ICS 205-930 on place aversion conditioning

1988 • 26 citations

Impairment by apomorphine of one-trial passive avoidance learning in mice: The opposing roles of the dopamine and noradrenaline systems

1979 • 25 citations

Intra-Amygdala Muscimol Injections Impair Freezing and Place Avoidance in Aversive Contextual Conditioning

2004 • 25 citations

Haloperidol and clonidine increase, and apomorphine decreases ultrasonic vocalizations by gerbils

1981 • 23 citations

Evidence that dopamine D3 receptors participate in clozapine-induced hypothermia

1995 • 22 citations

Involvement of GABAergic systems in benzodiazepine-induced impairment of passive avoidance learning in mice

1991 • 22 citations

The anxiolytic effect on the fear-potentiated startle is not due to a non-specific disruption

1998 • 19 citations

Effects of dopamine receptor blockade on avoidance performance: assessment of effects on cue—shock and response—outcome associations

1982 • 17 citations

Atypical Uses of Atypical Antipsychotics

2005 • 15 citations

Opposite effects of olanzapine and haloperidol in rat ultrasonic vocalization test.

2002 • 14 citations

Effect of a dopamine D1/5 receptor antagonist on haloperidol-induced inhibition of the acquisition of conditioned fear

2005 • 14 citations

The potential antipsychotic activity of the partial dopamine receptor agonist (+) N-0437

1990 • 11 citations

Effects of specific dopamine D1 and D2 receptor antagonists and agonists and neuroleptic drugs on emotional defecation in a rat model of akathisia

1998 • 11 citations

The effects of chlorpromazine on one-trial passive avoidance learning in mice: Further examination of pre- and post-learning administration

1970 • 8 citations

Neuroleptic-induced changes in the anxiolytic and myorelaxant properties of diazepam in the rat

1992 • 8 citations

Effects of apomorphine and clozapine on conditioned freezing and latent inhibition

2003 • 7 citations

The effects of chlorpromazine on the expression of an acquired passive avoidance response in mice

1970 • 6 citations

Low-dose clozapine pretreatment partially prevents haloperidol-induced deficits in conditioned active avoidance

2000 • 4 citations