Potentiation of beta-adrenergic signaling by adenoviral-mediated gene transfer in adult rabbit ventricular myocytes.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

1982 • 2,259 citations

Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy.

1994 • 1,599 citations

Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure.

1986 • 1,297 citations

Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme

1989 • 1,244 citations

Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

1993 • 877 citations

Adrenergic effects on the biology of the adult mammalian cardiocyte.

1992 • 873 citations

Enhanced Myocardial Function in Transgenic Mice Overexpressing the β ₂ -Adrenergic Receptor

1994 • 745 citations

Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor

1995 • 714 citations

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

1986 • 650 citations

The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.

1993 • 467 citations

Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.

1994 • 414 citations

Phosphorylation and Desensitization of the Human β1-Adrenergic Receptor

1995 • 317 citations

Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart.

1994 • 300 citations

Efficient catheter-mediated gene transfer into the heart using replication-defective adenovirus.

1994 • 285 citations

Beta-adrenoceptors in cardiac disease

1993 • 259 citations

Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo.

1993 • 255 citations

Beta 1-adrenoceptor stimulation and beta 2-adrenoceptor stimulation differ in their effects on contraction, cytosolic Ca2+, and Ca2+ current in single rat ventricular cells.

1993 • 241 citations

Reduced beta 1 receptor messenger RNA abundance in the failing human heart.

1993 • 237 citations

Sympathetic regulation of cardiac calcium current is due exclusively to cAMP-dependent phosphorylation

1991 • 231 citations

Prolonged and effective blockade of tumor necrosis factor activity through adenovirus-mediated gene transfer.

1994 • 220 citations

Reduced Contraction and Altered Frequency Response of Isolated Ventricular Myocytes From Patients With Heart Failure

1995 • 205 citations

Beta 2-adrenergic receptor-stimulated increase in cAMP in rat heart cells is not coupled to changes in Ca2+ dynamics, contractility, or phospholamban phosphorylation.

1994 • 199 citations

Myocardial signaling defects and impaired cardiac function of a human beta 2-adrenergic receptor polymorphism expressed in transgenic mice.

1996 • 177 citations

Highly efficient gene transfer into adult ventricular myocytes by recombinant adenovirus.

1993 • 170 citations

Heart failure in the 1990s: Evolutions of a major public health problem in cardiovascular medicine

1993 • 163 citations

Response of Failing Canine and Human Heart Cells to β ₂ -Adrenergic Stimulation

1995 • 135 citations

Inotropic responses to isoproterenol and phosphodiesterase inhibitors in intact guinea pig hearts: comparison of cyclic AMP levels and phosphorylation of sarcoplasmic reticulum and myofibrillar proteins.

1989 • 126 citations

Mutational Analysis of the Pleckstrin Homology Domain of the β-Adrenergic Receptor Kinase.

1995 • 114 citations

Oligodeoxynucleotides antisense to mRNA encoding protein kinase A, protein kinase C, and beta-adrenergic receptor kinase reveal distinctive cell-type-specific roles in agonist-induced desensitization.

1994 • 95 citations

Blockade of cardiac sodium channels by lidocaine. Single-channel analysis.

1989 • 64 citations

Morphometric study of cardiac muscle: the problem of tissue shrinkage.

1982 • 61 citations

Cardiac Muscarinic Potassium Channel Activity Is Attenuated by Inhibitors of G _βγ

1995 • 42 citations

Differences in desensitization between human β1- and β2-adrenergic receptors stably expressed in transfected hamster cells

1995 • 21 citations

Adenovirus infection of myocardial cells induces an enhanced sensitivity to beta-adrenergic agonists by increasing the concentration of the stimulatory G-protein.

1994 • 13 citations