The Mitotic Chromosome Binding Activity of the Papillomavirus E2 Protein Correlates with Interaction with the Cellular Chromosomal Protein, Brd4

Anatomy of hot spots in protein interfaces

1998 • 1,908 citations

The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

2003 • 635 citations

Transient replication of BPV-1 requires two viral polypeptides encoded by the E1 and E2 open reading frames.

1991 • 462 citations

Repression of human papillomavirus oncogenes in HeLa cervical carcinoma cells causes the orderly reactivation of dormant tumor suppressor pathways

2000 • 442 citations

Transactivation of a bovine papilloma virus transcriptional regulatory element by the E2 gene product

1985 • 402 citations

Interaction of the Bovine Papillomavirus E2 Protein with Brd4 Tethers the Viral DNA to Host Mitotic Chromosomes

2004 • 395 citations

Transcription in yeast activated by a putative amphipathic α helix linked to a DNA binding unit

1987 • 324 citations

The BPV1-E2 trans-acting protein can be either an activator or a repressor of the HPV18 regulatory region.

1987 • 294 citations

A Bromodomain Protein, MCAP, Associates with Mitotic Chromosomes and Affects G₂-to-M Transition

2000 • 281 citations

Identification of the origin of replication of bovine papillomavirus and characterization of the viral origin recognition factor E1.

1991 • 257 citations

The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicase.

1993 • 236 citations

Suppression of cellular proliferation by the papillomavirus E2 protein

1995 • 220 citations

Protein Interactions Targeting the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus to Cell Chromosomes

2002 • 197 citations

Mapping EBNA-1 Domains Involved in Binding to Metaphase Chromosomes

1999 • 182 citations

E2 polypeptides encoded by bovine papillomavirus type 1 form dimers through the common carboxyl-terminal domain: transactivation is mediated by the conserved amino-terminal domain.

1989 • 182 citations

Segregation of viral plasmids depends on tethering to chromosomes and is regulated by phosphorylation

1998 • 182 citations

Long-Term Episomal Maintenance of Bovine Papillomavirus Type 1 Plasmids Is Determined by Attachment to Host Chromosomes, Which Is Mediated by the Viral E2 Protein and Its Binding Sites

1999 • 179 citations

Bovine Papillomavirus Type 1 Genomes and the E2 Transactivator Protein Are Closely Associated with Mitotic Chromatin

1998 • 178 citations

A Mammalian Bromodomain Protein, Brd4, Interacts with Replication Factor C and Inhibits Progression to S Phase

2002 • 167 citations

Latent Nuclear Antigen of Kaposi’s Sarcoma-Associated Herpesvirus Interacts with RING3, a Homolog of the Drosophila Female Sterile Homeotic ( fsh ) Gene

1999 • 167 citations

EBP2, a Human Protein That Interacts with Sequences of the Epstein-Barr Virus Nuclear Antigen 1 Important for Plasmid Maintenance

1999 • 164 citations

You bet-cha: a novel family of transcriptional regulators

2001 • 163 citations

Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene

1993 • 159 citations

The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2

2004 • 155 citations

Cis and trans requirements for stable episomal maintenance of the BPV-1 replicator.

1996 • 153 citations

Transcriptional repression in eukaryotes: repressors and repression mechanisms

2003 • 138 citations

Targeted mutagenesis of the human papillomavirus type 16 E2 transactivation domain reveals separable transcriptional activation and DNA replication functions

1996 • 123 citations

Interaction of the Papillomavirus E2 Protein with Mitotic Chromosomes

2000 • 119 citations

Acidic transcription factors alleviate nucleosome-mediated repression of DNA replication of bovine papillomavirus type 1.

1994 • 117 citations

Separation of the DNA Replication, Segregation, and Transcriptional Activation Functions of Epstein-Barr Nuclear Antigen 1

2002 • 116 citations

Transactivation-Competent Bovine Papillomavirus E2 Protein Is Specifically Required for Efficient Repression of Human Papillomavirus Oncogene Expression and for Acute Growth Inhibition of Cervical Carcinoma Cell Lines

1998 • 112 citations

Structure of the intact transactivation domain of the human papillomavirus E2 protein

2000 • 106 citations

Mechanisms of Human Papillomavirus E2-Mediated Repression of Viral Oncogene Expression and Cervical Cancer Cell Growth Inhibition

2000 • 103 citations

The Linking Regions of EBNA1 Are Essential for Its Support of Replication and Transcription

1999 • 101 citations

A dimer of BPV-1 E2 containing a protease resistant core interacts with its DNA target.

1988 • 99 citations

A bovine papillomavirus E1-related protein binds specifically to bovine papillomavirus DNA

1991 • 98 citations

Coupling of Mitotic Chromosome Tethering and Replication Competence in Epstein-Barr Virus-Based Plasmids

2001 • 95 citations

Crystal Structure of the E2 Transactivation Domain of Human Papillomavirus Type 11 Bound to a Protein Interaction Inhibitor

2004 • 94 citations

Modulation of the Cell Division Cycle by Human Papillomavirus Type 18 E4

2002 • 86 citations

AMF-1/Gps2 Binds p300 and Enhances Its Interaction with Papillomavirus E2 Proteins

2000 • 84 citations

The activation domain of the bovine papillomavirus E2 protein mediates association of DNA-bound dimers to form DNA loops.

1991 • 78 citations

Multiple regions within EBNA1 can link DNAs

1995 • 70 citations

Genetic analysis of the activation domain of bovine papillomavirus protein E2: its role in transcription and replication

1996 • 66 citations

Transcriptional and replicational activation functions in the bovine papillomavirus type 1 E2 protein are encoded by different structural determinants

1996 • 65 citations

Reconstitution of Epstein-Barr virus-based plasmid partitioning in budding yeast

2001 • 65 citations

Latent nuclear antigen of Kaposi’s sarcoma herpesvirus/human herpesvirus-8 induces and relocates RING3 to nuclear heterochromatin regions

2002 • 63 citations

Functional analysis of the papilloma virus E2 trans-activator in Saccharomyces cerevisiae.

1989 • 62 citations

Phosphorylation sites of the E2 transcriptional regulatory proteins of bovine papillomavirus type 1

1989 • 62 citations

Interaction of the Papillomavirus Transcription/Replication Factor, E2, and the Viral Capsid Protein, L2

2000 • 61 citations

EBNA1 Partitions Epstein-Barr Virus Plasmids in Yeast Cells by Attaching to Human EBNA1-Binding Protein 2 on Mitotic Chromosomes

2003 • 59 citations

Cooperative Activation of Human Papillomavirus Type 8 Gene Expression by the E2 Protein and the Cellular Coactivator p300

2002 • 54 citations

Amino acids critical for the functions of the bovine papillomavirus type 1 E2 transactivator

1996 • 51 citations

Analysis of Chromatin Attachment and Partitioning Functions of Bovine Papillomavirus Type 1 E2 Protein

2004 • 50 citations

Reconstitution of papillomavirus E2-mediated plasmid maintenance in Saccharomyces cerevisiae by the Brd4 bromodomain protein

2005 • 43 citations

Genetic Analysis of the Bovine Papillomavirus E2 Transcriptional Activation Domain

1996 • 40 citations

Identification of Single Amino Acids in the Human Papillomavirus 11 E2 Protein Critical for the Transactivation or Replication Functions

1998 • 37 citations

Identification of Epstein-Barr Virus Nuclear Antigen 1 Protein Domains That Direct Interactions at a Distance between DNA-bound Proteins

1995 • 34 citations

The Transactivation and DNA Binding Domains of the BPV-1 E2 Protein Have Different Roles in Cooperative Origin Binding with the E1 Protein

1996 • 32 citations

Studies on the Mechanism of DNA Linking by Epstein-Barr Virus Nuclear Antigen 1

1997 • 32 citations

An acidic amphipathic helix in the Bovine Papillomavirus E2 protein is critical for DNA replication and interaction with the E1 protein

2004 • 26 citations

Conditional Mutations in the Mitotic Chromosome Binding Function of the Bovine Papillomavirus Type 1 E2 Protein

2005 • 24 citations

Two human papillomavirus DNAs molecularly cloned from a patient with epidermodysplasia verruciformis: restriction maps.

1988 • 2 citations