Fibroblast growth factor and heparin protect endothelial cells from the effects of interleukin 1

Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines.

1985 • 1,110 citations

Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells.

1984 • 944 citations

An endothelial cell growth factor from bovine hypothalamus: identification and partial characterization.

1979 • 727 citations

High and low affinity binding sites for basic fibroblast growth factor on cultured cells: Absence of a role for low affinity binding in the stimulation of plasminogen activator production by bovine capillary endothelial cells

1987 • 653 citations

Cytokine activation of vascular endothelium. Effects on tissue-type plasminogen activator and type 1 plasminogen activator inhibitor.

1988 • 561 citations

Cyclooxygenase is an immediate-early gene induced by interleukin-1 in human endothelial cells.

1990 • 484 citations

Interleukin 1 and lipopolysaccharide induce an inhibitor of tissue-type plasminogen activator in vivo and in cultured endothelial cells.

1986 • 414 citations

Heparin Binds Endothelial Cell Growth Factor, the Principal Endothelial Cell Mitogen in Bovine Brain

1984 • 391 citations

Prostacyclin Synthesis Induced in Vascular Cells by Interleukin-1

1985 • 364 citations

Tumor necrosis factor/cachectin stimulates peritoneal macrophages, polymorphonuclear neutrophils, and vascular endothelial cells to synthesize and release platelet-activating factor.

1987 • 364 citations

Factors involved in the modulation of cell proliferation in vivo and in vitro: The role of fibroblast and epidermal growth factors in the proliferative response of mammalian cells

1978 • 360 citations

Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor.

1986 • 326 citations

Regulation of the fibrinolytic system of cultured human vascular endothelium by interleukin 1.

1986 • 325 citations

Tumor necrosis factor increases the production of plasminogen activator inhibitor in human endothelial cells in vitro and in rats in vivo

1988 • 300 citations

Interleukin-1 activation of vascular endothelium. Effects on procoagulant activity and leukocyte adhesion.

1985 • 295 citations

Interleukin 1 induces interleukin 1. II. Recombinant human interleukin 1 induces interleukin 1 production by adult human vascular endothelial cells.

1987 • 279 citations

Metabolism of receptor-bound and matrix-bound basic fibroblast growth factor by bovine capillary endothelial cells.

1988 • 276 citations

Selectins: Novel Receptors that Mediate Leukocyte Adhesion During Inflammation

1991 • 264 citations

Production of interleukin 1 by human endothelial cells.

1986 • 264 citations

Interleukin 1 stimulates platelet activating factor production in cultured human endothelial cells

1986 • 232 citations

Tumor necrosis factor increases the production of plasminogen activator inhibitor in human endothelial cells in vitro and in rats in vivo

1988 • 232 citations

Self-regulation of procoagulant events on the endothelial cell surface.

1985 • 231 citations

Interleukin 1 is an autocrine regulator of human endothelial cell growth.

1990 • 197 citations

Interleukin 1 stimulates platelet-activating factor production in cultured human endothelial cells.

1986 • 172 citations

Multiple forms of endothelial cell growth factor. Rapid isolation and biological and chemical characterization.

1985 • 160 citations

Exaggerated human vascular cell prostaglandin biosynthesis mediated by monocytes: role of monokines and interleukin 1.

1985 • 142 citations

Modulation of endothelial cell functions by different molecular species of interleukin 1

1987 • 137 citations

Cachectin/TNF as well as interleukin-1 induces prostacyclin synthesis in cultured vascular endothelial cells

1986 • 124 citations

Differential regulation by cytokines of constitutive and stimulated secretion of von Willebrand factor from endothelial cells

1990 • 94 citations

A radioimmunoassay for thrombospondin, used in a comparative study of thrombospondin, β-thromboglobulin and platelet factor 4 in healthy volunteers

1983 • 88 citations

The addition of endothelial cell growth factor and heparin to human umbilical vein endothelial cell cultures decreases plasminogen activator inhibitor-1 expression.

1988 • 87 citations

IL-1 and related cytokines enhance thrombin-stimulated PGI2 production in cultured endothelial cells without affecting thrombin-stimulated von Willebrand factor secretion or platelet-activating factor biosynthesis.

1989 • 83 citations

Interleukin-4 counteracts pyrogen-induced downregulation of thrombomodulin in cultured human vascular endothelial cells

1991 • 74 citations

Basic fibroblast growth factor expression in human omental microvascular endothelial cells and the effect of phorbol ester

1990 • 64 citations

Culture‐induced increase in acidic and basic fibroblast growth factor activities and their association with the nuclei of vascular endothelial and smooth muscle cells

1991 • 61 citations

Effect of inflammatory cytokines on human endothelial cell proliferation

1990 • 59 citations

Immunohistochemical localization of basic and acidic fibroblast growth factors in the developing rat heart.

1991 • 58 citations

Enhancement by interleukin-1 (IL-1) of plasminogen activator inhibitor (PA-I) activity in cultured human endothelial cells

1986 • 51 citations

Inhibitory effect of human recombinant interleukin-1 α and β on growth of human vascular endothelial cells

1987 • 47 citations

Comparison of the ability of basic and acidic fibroblast growth factor to stimulate the proliferation of an established keratinocyte cell line: Modulation of their biological effects by heparin, transforming growth factor β (TGFβ), and epidermal growth factor (EGF)

1990 • 46 citations

Additive effects of il-1 and tnf on induction of prostacyclin synthesis in human vascular endothelial cells

1988 • 44 citations

Interleukin-1 stimulates prostacyclin production by cultured human endothelial cells by increasing arachidonic acid mobilization and conversion.

1990 • 41 citations

Enhanced release of von willebrand factor by human endothelial cells in culture in the presence of phorbol myristate acetate and interleukin 1.

1987 • 37 citations

Cytokine Regulation of the Synthesis of Plasminogen Activator Inhibitor-2 by Human Vascular Endothelial Cells

1993 • 34 citations

Stimulation of prostacyclin synthesis in vascular cells by mononuclear cell products

1984 • 33 citations

Monocytes enhance the bidirectional release of type I plasminogen activator inhibitor by endothelial cells

1990 • 31 citations

Effects of Heparin and Endothelial Cell Growth Supplement on Haemostatic Functions of Vascular Endothelium

1992 • 30 citations

Heparin and acidic fibroblast growth factor interact to decrease prostacyclin synthesis in human endothelial cells by affecting both prostaglandin H synthase and prostacyclin synthase

1990 • 27 citations

Substrate for endothelial prostacyclin production in the presence of platelets exposed to collagen is derived from the platelets rather than the endothelium

1986 • 25 citations

An in vitro model for the study of acute release of von Willebrand factor from human endothelial cells

1987 • 25 citations

Prostacyclin production by confluent and non-confluent human endothelial cells in culture

1984 • 22 citations

Quantitation of FcγRII mRNA in platelets and megakaryoblastic cell lines by a new method of in situ hybridization

1994 • 22 citations

Decreased prostacyclin production by human umbilical vein endothelial cells cultured with endothelial cell growth factor and heparin

1989 • 21 citations

The effect of heparin and other glycosaminoglycans on levels of tissue plasminogen activator and plasminogen activator inhibitor in cultured human umbilical vein endothelial cells.

1990 • 17 citations

The effect of heparin on fibronectin and thrombospondin synthesis and mRNA levels in cultured human endothelial cells

1990 • 17 citations

Acidic and Basic Fibroblast Growth Factors have Comparable Effects on the Haemostatic Function of Vascular Endothelium

1995 • 15 citations

The use of human endothelial cells cultured in flat wells and on microcarrier beads to assess tissue plasminogen activator and factor VIII related antigen release

1986 • 14 citations

Effect of human recombinant interleukin-Iα on release of prostacyclin from human endothelial cells

2006 • 13 citations

Heparin Enhances Endothelial Cell von Willebrand Factor Content by Growth Factor Dependent Mechanisms

1994 • 11 citations

Quantitation of platelet derived growth factor receptors on cells from human arterial segments

1994 • 6 citations