Human Septic Myopathy: Induction of Cyclooxygenase, Heme Oxygenase and Activation of the Ubiquitin Proteolytic Pathway

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

1992 • 12,726 citations

A new Simplified Acute Physiology Score (SAPS II) based on a European/North American multicenter study

1993 • 6,337 citations

One-Year Outcomes in Survivors of the Acute Respiratory Distress Syndrome

2003 • 2,141 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

Association between mitochondrial dysfunction and severity and outcome of septic shock

2002 • 1,401 citations

The Logistic Organ Dysfunction System

1996 • 726 citations

The Logistic Organ Dysfunction system. A new way to assess organ dysfunction in the intensive care unit. ICU Scoring Group

1996 • 550 citations

Normal Responses to Injury Prevent Systemic Inflammation and Can Be Immunosuppressive

2001 • 514 citations

Clinical manifestations of inspiratory muscle fatigue

1982 • 469 citations

Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle.

1997 • 264 citations

Proteolytic Degradation of Tyrosine Nitrated Proteins

2000 • 260 citations

Sepsis stimulates nonlysosomal, energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle.

1994 • 256 citations

Peroxynitrite Increases the Degradation of Aconitase and Other Cellular Proteins by Proteasome

1998 • 254 citations

Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids.

1996 • 249 citations

Early signs of critical illness polyneuropathy in ICU patients with systemic inflammatory response syndrome or sepsis

2000 • 237 citations

Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle

2003 • 215 citations

Neuromuscular sequelae of critical illness

2005 • 208 citations

Corticosterone Regulates Heme Oxygenase‐2 and NO Synthase Transcription and Protein Expression In Rat Brain

1994 • 148 citations

Preliminary observations on the neuromuscular abnormalities in patients with organ failure and sepsis

1993 • 144 citations

Induction of diaphragmatic nitric oxide synthase after endotoxin administration in rats: role on diaphragmatic contractile dysfunction.

1996 • 140 citations

Neuromuscular disorders associated with failure to wean from the ventilator

1995 • 137 citations

Effect of proteasome inhibition on cellular oxidative damage, antioxidant defences and nitric oxide production

2001 • 136 citations

Cyclooxygenase‐2 deficient mice are resistant to endotoxin‐induced inflammation and death

2003 • 114 citations

Muscular Contractile Failure in Septic Patients

2000 • 110 citations

Expression of Inducible Nitric Oxide Synthase in Failing and Non-failing Human Heart

1996 • 99 citations

Endotoxin-induced skeletal muscle contractile dysfunction: contribution of nitric oxide synthases

1998 • 97 citations

Tumor necrosis factor alpha decreases in vivo diaphragm contractility in dogs.

1994 • 97 citations

Activity and expression of the 20S proteasome are increased in skeletal muscle during sepsis

1999 • 97 citations

Induction of Nitric Oxide Synthase and Dual Effects of Nitric Oxide and Cyclooxygenase Products in Regulation of Arterial Contraction in Human Septic Shock

1999 • 95 citations

High Output Respiratory Failure

1963 • 94 citations

Respiratory muscle dysfunction in sepsis.

1998 • 91 citations

High-dose tumor necrosis factor alpha produces an impairment of hamster diaphragm contractility. Attenuation with a prostaglandin inhibitor.

1996 • 74 citations

Protective Role of Heme Oxygenases against Endotoxin-induced Diaphragmatic Dysfunction in Rats

2001 • 73 citations

Endotoxemia reduces skeletal muscle protein synthesis in neonates

2002 • 62 citations

Inducible nitric oxide synthase (NOS2) expressed in septic patients is nitrated on selected tyrosine residues: implications for enzymic activity

2002 • 57 citations

Role of ubiquitin-proteasome pathway in skeletal muscle wasting in rats with endotoxemia

2003 • 54 citations

Evaluation of the logistic organ dysfunction system for the assessment of organ dysfunction and mortality in critically ill patients

2001 • 54 citations

Induction of Cardiac Nitric Oxide Synthase 2 in Rats Exposed to Chronic Hypoxia

1999 • 51 citations

Activation of Cardiac Endothelium as a Compensatory Component in Endotoxin-Induced Cardiomyopathy

2001 • 48 citations

Fiber type-specific expression of major proteolytic systems in fast- to slow-transforming rabbit muscle

2001 • 44 citations

Sepsis is associated with increased ubiquitinconjugating enzyme E2_14k mRNA in skeletal muscle

1999 • 38 citations

The crucial role of systemic responses in the innate (non-adaptive) host defense

2001 • 31 citations

Preventive Effects of Indomethacin on Diaphragmatic Contractile Alterations in Endotoxemic Rats

1990 • 28 citations

Diaphragmatic failure during group B streptococcal sepsis in piglets: the role of thromboxane A2

1995 • 14 citations