Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy

2001 • 3,292 citations

Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

2001 • 1,714 citations

The acidosis of chronic renal failure activates muscle proteolysis in rats by augmenting transcription of genes encoding proteins of the ATP-dependent ubiquitin-proteasome pathway.

1996 • 440 citations

Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain

2001 • 383 citations

The N‐end rule pathway of protein degradation

1997 • 354 citations

Glucocorticoids and muscle catabolism

1999 • 290 citations

Muscle Cachexia: Current Concepts of Intracellular Mechanisms and Molecular Regulation

2001 • 285 citations

Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle.

1997 • 264 citations

Sepsis stimulates nonlysosomal, energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle.

1994 • 256 citations

Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids.

1996 • 249 citations

Sepsis stimulates release of myofilaments in skeletal muscle by a calcium‐dependent mechanism

1999 • 191 citations

Regulation of Microtubule Dynamics and Myogenic Differentiation by Murf, a Striated Muscle Ring-Finger Protein

2000 • 171 citations

Rates of ubiquitin conjugation increase when muscles atrophy, largely through activation of the N-end rule pathway

1998 • 155 citations

Total and myofibrillar protein breakdown in different types of rat skeletal muscle: Effects of sepsis and regulation by insulin

1989 • 147 citations

Burn injury stimulates multiple proteolytic pathways in skeletal muscle, including the ubiquitin-energy-dependent pathway.

1995 • 99 citations

Intracellular regulation of protein degradation during sepsis is different in fast- and slow-twitch muscle

1997 • 98 citations

Effect of the glucocorticoid receptor antagonist RU 38486 on muscle protein breakdown in sepsis.

1991 • 75 citations

Respiratory muscle injury in animal models and humans.

1998 • 59 citations

The Gene Expression of Ubiquitin Ligase E3α Is Upregulated in Skeletal Muscle during Sepsis in Rats—Potential Role of Glucocorticoids

2000 • 55 citations

Sepsis is associated with increased ubiquitinconjugating enzyme E2_14k mRNA in skeletal muscle

1999 • 38 citations

Is the metabolic response to sepsis in skeletal muscle different in infants and adults? An experimental study in rats

1992 • 25 citations