2.1 Å Crystal Structure of Human PXR in Complex with the St. John's Wort Compound Hyperforin^,

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

1998 • 1,535 citations

Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin

2001 • 843 citations

Cytochrome P4502C9: an enzyme of major importance in human drug metabolism

1998 • 820 citations

Structural Evidence for Ligand Specificity in the Binding Domain of the Human Androgen Receptor

2000 • 587 citations

THE JOURNAL OF BIOLOGICAL CHEMISTRY.

1905 • 551 citations

The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged during Evolution

2000 • 487 citations

Effects of St. John's Wort on Irinotecan Metabolism

2002 • 447 citations

Regulation ofCYP3AGene Transcription by the Pregnane X Receptor

2002 • 325 citations

St John's Wort increases expression of P‐glycoprotein: Implications for drug interactions

2002 • 280 citations

St John's wort, a herbal antidepressant, activates the steroid X receptor

2000 • 236 citations

Data collection and processing

2013 • 199 citations

Use of the nuclear receptor PXR to predict drug interactions

2000 • 183 citations

Hyperforin enhances the extracellular concentrations of catecholamines, serotonin and glutamate in the rat locus coeruleus

1999 • 106 citations

The scientific, quasi-scientific and popular literature on the use of St. John’s Wort in the treatment of depression

1998 • 65 citations