Serum leptin level and cognition in the elderly: Findings from the Health ABC Study

The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

2001 • 4,874 citations

Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI.

1990 • 2,936 citations

The Modified Mini-Mental State (3MS) examination.

1987 • 2,628 citations

A wilcoxon‐type test for trend

1985 • 1,812 citations

Factorial and discriminant validity of the center for epidemiological studies depression (CES-D) scale

1986 • 764 citations

Inflammatory markers and cognition in well-functioning African-American and white elders

2003 • 686 citations

Direct antidiabetic effect of leptin through triglyceride depletion of tissues

1997 • 664 citations

Gonadal Hormones Determine Sensitivity to Central Leptin and Insulin

2006 • 533 citations

Is Diabetes Associated With Cognitive Impairment and Cognitive Decline Among Older Women?

2000 • 512 citations

Diabetes, impaired fasting glucose, and development of cognitive impairment in older women

2004 • 504 citations

Triglycerides Induce Leptin Resistance at the Blood-Brain Barrier

2004 • 492 citations

Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents

2002 • 422 citations

Leptin Enhances NMDA Receptor Function and Modulates Hippocampal Synaptic Plasticity

2001 • 396 citations

Complete rescue of obesity, diabetes, and infertility in db/db mice by neuron-specific LEPR-B transgenes

2005 • 377 citations

Insulin promotes rapid delivery of N -methyl- <scp>d</scp> - aspartate receptors to the cell surface by exocytosis

2001 • 300 citations

Effects of leptin on memory processing

2005 • 297 citations

Obesity‐related leptin regulates Alzheimer's Aβ

2004 • 288 citations

Leptin and Aging: Correlation with Endocrine Changes in Male and Female Healthy Adult Populations of Different Body Weights

2000 • 244 citations

Transgenic Overexpression of Leptin Rescues Insulin Resistance and Diabetes in a Mouse Model of Lipoatrophic Diabetes

2001 • 239 citations

Impaired transport of leptin across the blood-brain barrier in obesity is acquired and reversible

2003 • 230 citations

Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin.

1999 • 211 citations

Leptin restores euglycemia and normalizes glucose turnover in insulin-deficient diabetes in the rat.

1999 • 200 citations

Leptin and its role in hippocampal synaptic plasticity

2006 • 195 citations

Leptin-mediated Cell Survival Signaling in Hippocampal Neurons Mediated by JAK STAT3 and Mitochondrial Stabilization

2007 • 191 citations

Orexin-A (Hypocretin-1) and leptin enhance LTP in the dentate gyrus of rats in vivo

2004 • 190 citations

Neuroprotective Effects of Leptin Against Ischemic Injury Induced by Oxygen-Glucose Deprivation and Transient Cerebral Ischemia

2007 • 180 citations

Glycosylated hemoglobin level and development of mild cognitive impairment or dementia in older women.

2006 • 177 citations

Longevity, lipotoxicity and leptin: the adipocyte defense against feasting and famine

2004 • 169 citations

Leptin Protects against 6-Hydroxydopamine-induced Dopaminergic Cell Death via Mitogen-activated Protein Kinase Signaling

2007 • 160 citations

Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats

2001 • 153 citations

Circulating Leptin Levels and Weight Loss in Alzheimer’s Disease Patients

2001 • 146 citations

The role of leptin resistance in the lipid abnormalities of aging

2001 • 145 citations

Antiapoptotic Effects of Leptin in Human Neuroblastoma Cells

2004 • 143 citations

Clinical Aspects of Leptin

1998 • 136 citations

Diabetes and Function in Different Cognitive Systems in Older Individuals Without Dementia

2006 • 124 citations

Central leptin increases insulin sensitivity in streptozotocin-induced diabetic rats

2002 • 121 citations

Predictors of Decline in MMSE Scores Among Older Mexican Americans

2002 • 113 citations

The Suppressor of Cytokine Signaling 3 Inhibits Leptin Activation of AMP-Kinase in Cultured Skeletal Muscle of Obese Humans

2006 • 109 citations

Nutritional Status, Cognition, and Survival

2005 • 109 citations

The Role of Leptin in the Development of the Cerebral Cortex in Mouse Embryos

2005 • 104 citations

Distribution, function, and properties of leptin receptors in the brain

2003 • 94 citations

Leptin Levels in Type 2 Diabetes: Associations with Measures of Insulin Resistance and Insulin Secretion

2003 • 93 citations

Glucose metabolism and insulin sensitivity in transgenic mice overexpressing leptin with lethal yellow agouti mutation: usefulness of leptin for the treatment of obesity-associated diabetes.

1999 • 92 citations

Weight loss precedes dementia in community-dwelling older adults.

1998 • 91 citations

Impaired long-term potentiation in obese zucker rats: possible involvement of presynaptic mechanism

2003 • 83 citations

Aging Is Associated With Resistance to Effects of Leptin on Fat Distribution and Insulin Action

2002 • 83 citations

Decreased leptin uptake in hypothalamic nuclei with ageing in Wistar rats

2001 • 80 citations

Dietary and lifestyle factors in relation to plasma leptin concentrations among normal weight and overweight men

2001 • 80 citations

Adipocytokines, Fat Distribution, and Insulin Resistance in Elderly Men and Women

2004 • 70 citations

Leptin and Aging: Correlation with Endocrine Changes in Male and Female Healthy Adult Populations of Different Body Weights

2000 • 67 citations

Relation Between Leptin and the Metabolic Syndrome in Elderly Women

2004 • 66 citations

Central regulation of energy balance: inputs, outputs and leptin resistance

2005 • 65 citations

Leptin: A Multifaceted Hormone in the Central Nervous System

2003 • 51 citations

Leptin signaling and aging: insight from caloric restriction

2001 • 49 citations

Diabetes mellitus and the rate of cognitive ageing

2000 • 41 citations

Shp2 as a therapeutic target for leptin resistance and obesity

2006 • 35 citations

Hormones and body composition in humans: clinical studies

2000 • 33 citations

The age-related inverse relationship between ob and lipogenic enzymes genes expression in rat white adipose tissue

2003 • 25 citations

Decreased leptin uptake in hypothalamic nuclei with aging in wistar rats

2000 • 13 citations

[Leptin and clustering of the components of risk factors for metabolic syndrome].

2004 • 5 citations