Smad expression of hepatic stellate cells in liver cirrhosis in vivo and hepatic stellate cell line in vitro

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

Transforming Growth Factor β in Tissue Fibrosis

1994 • 3,055 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

1993 • 1,444 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

1992 • 984 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Hepatic lipocytes: the principal collagen-producing cells of normal rat liver.

1985 • 839 citations

Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.

1995 • 672 citations

Perisinusoidal Stellate Cells (Fat-Storing Cells, Interstitial Cells, Lipocytes), Their Related Structure in and around the Liver Sinusoids, and Vitamin A-Storing Cells in Extrahepatic Organs

1980 • 532 citations

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.

1996 • 528 citations

Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis. A combined immunohistochemical and in situ hybridization study.

1994 • 470 citations

Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes

1997 • 439 citations

TGF-β receptor signaling

1997 • 417 citations

Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation.

1995 • 414 citations

Immunocytochemical Detection of Desmin in Fat-Storing Cells (Ito Cells)

1984 • 393 citations

Vitamin A-containing lipocytes and formation of type III collagen in liver injury.

1976 • 346 citations

Purified Rat Liver Fat-Storing Cells in Culture Divide and Contain Collagen

1984 • 326 citations

The hepatic stellate (Ito) cell: its role in human liver disease

1997 • 308 citations

Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.

1995 • 306 citations

Expression of the gene of the α-smooth muscle-actin isoform in rat liver and in rat fat-storing (ITO) cells

1990 • 283 citations

Transforming growth factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease.

1991 • 266 citations

Inhibition of transforming growth factorβ prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats

2000 • 243 citations

Regulation of extracellular matrix synthesis by transforming growth factor β1 in human fat-storing cells

1993 • 230 citations

Modulation of transforming growth factorβ response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts

2000 • 225 citations

Glial fibrillary acidic protein - a cell type specific marker for Ito cells in vivo and in vitro

1996 • 177 citations

Comparison of glial fibrillary acidic protein and desmin staining in normal and CCl4-induced fibrotic rat livers

1996 • 158 citations

The hepatitis B virus encoded oncoprotein pX amplifies TGF-β family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis

2001 • 141 citations

Cellular and molecular aspects of hepatic fibrosis

1993 • 138 citations

Hepatocyte proliferation in primary biliary cirrhosis as assessed by proliferating cell nuclear antigen and Ki-67 antigen labelling

1995 • 127 citations

Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells

2001 • 113 citations

Differential expression of collagen types I, III, and IV by fat-storing (Ito) cells in vitro

1992 • 89 citations

Transforming growth factor β and activin tonically inhibit DNA synthesis in the rat liver

2001 • 84 citations

Dominant-Negative Smad2 Mutants Inhibit Activin/Vg1 Signaling and Disrupt Axis Formation in Xenopus

1999 • 77 citations

Perisinusoidal lipocytes and fibrogenesis.

1994 • 74 citations

Collagen Production by Rat Hepatocytes and Sinusoidal Cells in Primary Monolayer Culture

2007 • 69 citations

Regulatory mechanisms for transforming growth factorβ as an autocrine inhibitor in human hepatocellular carcinoma: Implications for roles of Smads in its growth

2000 • 48 citations

Genomic locus and promoter region of rat Smad7, an important antagonist of TGFβ signaling

2000 • 38 citations

Cell growth and differentiation of a novel mouse Ito (fat-storing) cell line transformed by a temperature-sensitive mutant of simian virus 40

1997 • 18 citations

Inhibitory effects of antisense oligonucleotides on the expression of procollagen type III gene in mouse hepatic stellate cells transformed by simian virus 40

2000 • 13 citations