Construction of a US3 lacZ insertion mutant of herpes simplex virus type 2 and characterization of its phenotype in vitro and in vivo

A SIMPLE METHOD OF ESTIMATING FIFTY PER CENT ENDPOINTS12

1938 • 19,183 citations

A simple method of estimating 50 per cent end points

1938 • 8,381 citations

Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.

1987 • 4,937 citations

Mapping of Herpes Simplex Virus-1 Neurovirulence to γ ₁ 34.5, a Gene Nonessential for Growth in Culture

1990 • 705 citations

A herpes simplex virus mutant in which glycoprotein D sequences are replaced by beta-galactosidase sequences binds to but is unable to penetrate into cells

1988 • 514 citations

Genetics of natural resistance to herpesvirus infections in mice

1975 • 342 citations

Regulation of cytomegalovirus gene expression: alpha and beta promoters are trans activated by viral functions in permissive human fibroblasts

1985 • 229 citations

Comparative Neurovirulence of Herpes Simplex Virus Type 1 Strains After Peripheral or Intracerebral Inoculation of BALB/c Mice

1983 • 226 citations

THE PATHOGENESIS OF HERPES VIRUS ENCEPHALITIS

1964 • 215 citations

Virulence of and establishment of latency by genetically engineered deletion mutants of herpes simplex virus I

1988 • 199 citations

Herpes simplex virus 1 protein kinase is encoded by open reading frame US3 which is not essential for virus growth in cell culture

1987 • 192 citations

DNA Sequence and Genetic Content of the HindIII l Region in the Short Unique Component of the Herpes Simplex Virus Type 2 Genome: Identification of the Gene Encoding Glycoprotein G, and Evolutionary Comparisons

1987 • 179 citations

Clustering of Genes Dispensable for Growth in Culture in the S Component of the HSV-1 Genome

1987 • 173 citations

The herpes simplex virus 1 protein kinase encoded by the US3 gene mediates posttranslational modification of the phosphoprotein encoded by the UL34 gene

1991 • 164 citations

Identification of new protein kinase-related genes in three herpesviruses, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus

1989 • 163 citations

Ribonucleotide Reductase Encoded by Herpes Simplex Virus Is a Determinant of the Pathogenicity of the Virus in Mice and a Valid Antiviral Target

1988 • 147 citations

Alphaherpesviruses possess a gene homologous to the protein kinase gene family of eukaryotes and retroviruses

1986 • 139 citations

VIRUSES AND THE VERSATILE MACROPHAGE

1985 • 136 citations

Herpes simplex virus phosphoproteins. II. Characterization of the virion protein kinase and of the polypeptides phosphorylated in the virion

1980 • 121 citations

Identification of the Herpes Simplex Virus Protein Kinase as the Product of Viral Gene US3

1987 • 121 citations

β-galactosidase as a marker in the peripheral and neural tissues of the herpes simplex virus-infected mouse

1988 • 116 citations

Molecular and biological characterization of a herpes simplex virus type 1 (HSV-1) neuroinvasiveness gene.

1990 • 95 citations

Differences in Neurovirulence among Isolates of Herpes Simplex Virus Types 1 and 2 in Mice using Four Routes of Infection

1981 • 89 citations

The Pathogenicity of Ribonucleotide Reductase-Null Mutants of Herpes Simplex Virus Type 1 in Mice

1991 • 85 citations

Replication of herpes simplex virus type 1 in macrophages from resistant and susceptible mice

1979 • 84 citations

Complementary lethal invasion of the central nervous system by nonneuroinvasive herpes simplex virus types 1 and 2

1991 • 74 citations

A single-base change within the DNA polymerase locus of herpes simplex virus type 2 can confer resistance to aphidicolin

1987 • 69 citations

Viral Aspects of Protein Phosphorylation

1988 • 66 citations

Detailed analysis of the mRNAs mapping in the short unique region of herpes simplex virus type 1

1985 • 59 citations

Herpes simplex virus neurovirulence and productive infection of neural cells is associated with a function which maps between 0.82 and 0.832 map units on the hsv genome

1989 • 58 citations

Herpes simplex virus type 1 pathogenicity in footpad and ear skin of mice depends on Langerhans cell density, mouse genetics, and virus strain

1987 • 58 citations

Role of macrophages in hepatitis induced by Herpes simplex virus types 1 and 2 in mice

1977 • 52 citations

Genetic and biological analyses of a herpes simplex virus intertypic recombinant reduced specifically for neurovirulence

1987 • 49 citations

Studies of L Cells Persistently Infected with VSV: Factors Involved in the Regulation of Persistent Infection

1977 • 49 citations

Genetics of macrophage-controlled resistance to hepatitis induced by herpes simplex virus type 2 in mice

1977 • 48 citations

A Variant of Herpes Simplex Virus Type 2 Strain HG52 with a 1.5 kb Deletion in RL between 0 to 0.02 and 0.81 to 0.83 Map Units Is Non-neurovirulent for Mice

1989 • 45 citations

Macrophages and age-dependent resistance to hepatitis induced by herpes simplex virus type 2 im mice

1978 • 45 citations

Repair replication of viral and cellular DNA in herpes simplex virus type 2-infected human embryonic and xeroderma pigmentosum cells

1981 • 44 citations

Phosphorylation of ribosomal proteins in hamster fibroblasts infected with pseudorabies virus or herpes simplex virus

1981 • 42 citations

Characteristics of the Induction of a New Protein Kinase in Cells Infected with Herpesviruses

1986 • 41 citations

HSV-1 DNA sequence determining intraperitoneal pathogenicity in mice is required for transcription of viral immediate-early genes in macrophages

1988 • 41 citations

Intrinsic resistance to viral infection. Mouse macrophage restriction of herpes simplex virus replication.

1988 • 39 citations

Isolation of herpes simplex virus DNA from the“Hirt supernatant”

1976 • 36 citations

Evidence that the gene for herpes simplex virus type 1 DNA polymerase accounts for the capacity of an intertypic recombinant to spread from eye to central nervous system

1988 • 33 citations

Partial purification and characterization of a new phosphoprotein kinase from cells infected with pseudorabies virus

1985 • 30 citations

Localization of a herpes simplex virus neurovirulence gene dissociated from high-titer virus replication in the brain

1988 • 27 citations

Electroblotting of double-stranded DNA for hybridization experiments: DNA transfer is complete within 10 minutes after pulsed-field gel electrophoresis

1990 • 24 citations

Molecular Cloning of Herpes Simplex Virus Type 2 DNA

1986 • 23 citations

Characterization of RNA transcripts from herpes simplex virus-1 DNA fragment BamHI-B

1989 • 22 citations

Herpes Simplex Virus

1989 • 18 citations

Nucleotide sequences responsible for the inability of a herpes simplex virus type 2 strain to grow in human lymphocytes are identical to those responsible for its inability to grow in mouse tissues following ocular infection

1990 • 8 citations