Novel pathophysiological concepts of inflammatory bowel disease

The immunological and genetic basis of inflammatory bowel disease

2003 • 1,766 citations

Increased expression of interleukin 17 in inflammatory bowel disease

2002 • 1,638 citations

Enhanced Th1 Activity and Development of Chronic Enterocolitis in Mice Devoid of Stat3 in Macrophages and Neutrophils

1999 • 1,228 citations

Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5.

1996 • 1,227 citations

Immunity, Inflammation, and Allergy in the Gut

2005 • 1,036 citations

What does Stat3 do?

2002 • 810 citations

Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis

2004 • 746 citations

Alterations of the dominant faecal bacterial groups in patients with Crohn's disease of the colon

2003 • 733 citations

What does Stat3 do?

2002 • 685 citations

Oxazolone Colitis, a Th2 Colitis Model Resembling Ulcerative Colitis, Is Mediated by IL-13-Producing NK-T Cells

2002 • 639 citations

CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells

2003 • 632 citations

A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn’s disease☆

2004 • 626 citations

Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells

1997 • 582 citations

IL-18, a Novel Immunoregulatory Cytokine, Is Up-Regulated in Crohn’s Disease: Expression and Localization in Intestinal Mucosal Cells

1999 • 576 citations

Crohn’s disease and the NOD2 gene: a role for paneth cells

2003 • 528 citations

Lack of common NOD2 variants in Japanese patients with Crohn's disease

2002 • 485 citations

Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota

2005 • 477 citations

STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: A critical role of STAT3 in innate immunity

2003 • 389 citations

Damaged epithelia regenerated by bone marrow–derived cells in the human gastrointestinal tract

2002 • 384 citations

Dietary Risk Factors for Inflammatory Bowel Disease

2005 • 380 citations

Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells

2003 • 335 citations

Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells

2003 • 308 citations

Interleukin-21 enhances T-helper cell type I signaling and interferon-γ production in Crohn’s disease

2005 • 287 citations

Early development of stricturing or penetrating pattern in Crohn's disease is influenced by disease location, number of flares, and smoking but not by NOD2/CARD15 genotype

2003 • 279 citations

The Epidemiology and Phenotype of Crohn’s Disease in the Chinese Population

2004 • 240 citations

Abnormally Differentiated Subsets of Intestinal Macrophage Play a Key Role in Th1-Dominant Chronic Colitis through Excess Production of IL-12 and IL-23 in Response to Bacteria

2005 • 210 citations

Recent Developments in the Immunology of Inflammatory Bowel Disease

2000 • 206 citations

Inhibitory effect of probiotic Escherichia coli strain Nissle 1917 on adhesion to and invasion of intestinal epithelial cells by adherent–invasive E. coli strains isolated from patients with Crohn's disease

2003 • 200 citations

Treatment of ulcerative colitis by feeding with germinated barley foodstuff: first report of a multicenter open control trial

2002 • 191 citations

Constitutive STAT3 Activation in Intestinal T Cells from Patients with Crohn's Disease

2003 • 185 citations

An analysis of 10218 ulcerative colitis cases in China

2002 • 172 citations

Card15 gene overexpression in mononuclear and epithelial cells of the inflamed Crohn's disease colon

2003 • 150 citations

Crohn's disease

2003 • 149 citations

T-bet upregulation and subsequent interleukin 12 stimulation are essential for induction of Th1 mediated immunopathology in Crohn's disease

2004 • 146 citations

Interleukins 4 and 13 Increase Intestinal Epithelial Permeability by a Phosphatidylinositol 3-Kinase Pathway

2000 • 141 citations

Osteopontin/Eta-1 upregulated in Crohn's disease regulates the Th1 immune response

2005 • 116 citations

Germinated barley foodstuff, a prebiotic product, ameliorates inflammation of colitis through modulation of the enteric environment

2003 • 110 citations

The Suppressive Effect of Bifidobacteria on Bacteroides vulgatus, a Putative Pathogenic Microbe in Inflammatory Bowel Disease

2003 • 106 citations

Role of bacteria in experimental colitis

2003 • 98 citations

CARD15/NOD2 Risk Alleles in the Development of Crohn's Disease in the Australian Population

2003 • 97 citations

Molecular and clinical basis for the regeneration of human gastrointestinal epithelia

2004 • 94 citations

Matrix metalloproteinase-3 secretion from human colonic subepithelial myofibroblasts: role of interleukin-17

2003 • 91 citations

Appendectomy Protects Against The Development of Ulcerative Colitis and Reduces Its Recurrence: Results of A Multicenter Case-Controlled Study in Japan

2001 • 87 citations

Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis

2004 • 84 citations

Association of NOD2 with Crohn's Disease in a homogenous Irish population

2003 • 84 citations

Colonic subepithelial myofibroblasts in mucosal inflammation and repair: contribution of bone marrow-derived stem cells to the gut regenerative response

2005 • 83 citations

HLA-linked susceptibility and resistance genes in Crohn's disease

1995 • 81 citations

Update in inflammatory bowel disease pathogenesis

2004 • 77 citations

Increase of Bone Marrow–Derived Secretory Lineage Epithelial Cells During Regeneration in the Human Intestine

2005 • 72 citations

Effects of IL-12 and IL-23 on Antigen-Presenting Cells at the Interface Between Innate and Adaptive Immunity

2002 • 53 citations

Card15 and Crohn's Disease: Healthy Homozygous Carriers of the 3020insC Frameshift Mutation

2003 • 45 citations

Intestinal subepithelial myofibroblasts in inflammatory bowel diseases

2002 • 38 citations

The pathophysiologic rationale for biological therapies in inflammatory bowel disease.

2005 • 36 citations

Interleukin-17 augments tumor necrosis factor-α-induced granulocyte and granulocyte/macrophage colony-stimulating factor release from human colonic myofibroblasts

2005 • 34 citations

Butyrate blocks interferon-γ-inducible protein-10 release in human intestinal subepithelial myofibroblasts

2005 • 31 citations

Amelioration of Murine Colitis by Feeding a Solution of LysedEscherichia coli

2003 • 28 citations

Significant role of genetics in IBD: the NOD2 gene.

2003 • 26 citations

Genetics of inflammatory bowel disease

2003 • 23 citations

Medium-chain triglyceride-rich enteral nutrition is more effective than low-fat enteral nutrition in rat colitis, but is equal in enteritis

2001 • 16 citations

Mucosal T cells as a target for treatment of IBD.

2003 • 15 citations

A case-control study of ulcerative colitis in relation to dietary and other factors in Japan. The Epidemiology Group of the Research Committee of Inflammatory Bowel Disease in Japan.

1995 • 4 citations