SV2 Is the Protein Receptor for Botulinum Neurotoxin A

THE SYNAPTIC VESICLE CYCLE

2004 • 2,413 citations

Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

1992 • 1,792 citations

Botulinum Toxin as a Biological Weapon

2001 • 1,750 citations

Neurotoxins Affecting Neuroexocytosis

2000 • 1,230 citations

Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25

1993 • 1,200 citations

Identification of a transmembrane glycoprotein specific for secretory vesicles of neural and endocrine cells.

1985 • 716 citations

Botulinum neurotoxins serotypes A and E cleave SNAP‐25 at distinct COOH‐terminal peptide bonds

1993 • 433 citations

How do tetanus and botulinum toxins bind to neuronal membranes?

1986 • 395 citations

Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)

1999 • 394 citations

Differential expression of synaptic vesicle protein 2 (SV2) isoforms

1994 • 391 citations

SV2A and SV2B Function as Redundant Ca2+ Regulators in Neurotransmitter Release

1999 • 350 citations

Exo-endocytotic recycling of synaptic vesicles in developing processes of cultured hippocampal neurons

1992 • 336 citations

Acceptors for botulinum neurotoxin reside on motor nerve terminals and mediate its internalization

1984 • 320 citations

Identification of protein receptor for Clostridium botulinum type B neurotoxin in rat brain synaptosomes.

1994 • 307 citations

Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells

2003 • 289 citations

Synaptotagmins I and II Act as Nerve Cell Receptors for Botulinum Neurotoxin G

2004 • 236 citations

The high‐affinity binding of Clostridium botulinum type B neurotoxin to synaptotagmin II associated with gangliosides G_T1b/G_D1a

1996 • 219 citations

The H_CC‐domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction

2003 • 218 citations

SV2C is a synaptic vesicle protein with an unusually restricted localization: anatomy of a synaptic vesicle protein family

1999 • 208 citations

Synaptic Vesicle Protein 2 Enhances Release Probability at Quiescent Synapses

2006 • 205 citations

Clostridial Toxins as Therapeutic Agents: Benefits of Nature's Most Toxic Proteins

1999 • 174 citations

Influence of nerve‐ending activity and of drugs on the rate of paralysis of rat diaphragm preparation by Cl. botulinum type A toxin

1962 • 165 citations

Uptake of Botulinum Neurotoxin into Cultured Neurons

2003 • 165 citations

Interaction between Clostridium botulinum neurotoxin and gangliosides

1980 • 156 citations

Presynaptic receptor arrays for clostridial neurotoxins

2004 • 154 citations

Botulinum Neurotoxin A Activity Is Dependent upon the Presence of Specific Gangliosides in Neuroblastoma Cells Expressing Synaptotagmin I

2002 • 131 citations

Gangliosides are the binding substances in neural cells for tetanus and botulinum toxins in mice

1999 • 111 citations

Ganglioside inactivation of botulinum toxin

1971 • 104 citations

Complex Gangliosides at the Neuromuscular Junction Are Membrane Receptors for Autoantibodies and Botulinum Neurotoxin But Redundant for Normal Synaptic Function

2002 • 103 citations

Purification of Clostridium botulinum Type A Neurotoxin

2003 • 84 citations

Botulinum Neurotoxin A Changes Conformation upon Binding to Ganglioside GT1b

2004 • 65 citations