Median eminence nitric oxide signaling

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.

1990 • 3,304 citations

Localization of nitric oxide synthase indicating a neural role for nitric oxide

1990 • 2,996 citations

Nitric oxide synthases in mammals

1994 • 2,762 citations

Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study

1991 • 2,139 citations

Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo

1990 • 1,869 citations

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

1989 • 1,850 citations

Nitric Oxide Signaling in the Central Nervous System

1995 • 1,628 citations

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.

1989 • 1,443 citations

Nitric oxide activates guanylate cyclase and increases guanosine 3′:5′-cyclic monophosphate levels in various tissue preparations

1977 • 1,422 citations

Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase

1991 • 1,364 citations

Induction by cyclic GMP of cationic conductance in plasma membrane of retinal rod outer segment

1985 • 1,213 citations

Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one.

1995 • 1,102 citations

Induction of calcium-dependent nitric oxide synthases by sex hormones.

1994 • 1,074 citations

Gases as biological messengers: nitric oxide and carbon monoxide in the brain

1994 • 1,052 citations

Cell Membrane and Nuclear Estrogen Receptors (ERs) Originate from a Single Transcript: Studies of ERα and ERβ Expressed in Chinese Hamster Ovary Cells

1999 • 1,046 citations

Immortalization of hypothalamic GnRH by genetically targeted tumorigenesis

1990 • 959 citations

Estrogen receptor α mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen

1999 • 895 citations

Nitric Oxide and Synaptic Function

1994 • 779 citations

Role of leptin in hypothalamic–pituitary function

1997 • 744 citations

Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity.

1994 • 658 citations

Neuronal localization of cannabinoid receptors in the basal ganglia of the rat

1991 • 515 citations

Nitric oxide synthase: expression and expressional control of the three isoforms

1995 • 479 citations

Surgical Disconnection of the Medial Basal Hypothalamus and Pituitary Function in the Rhesus Monkey. I. Gonadotropin Secretion¹,²

1975 • 473 citations

L-N6-(1-Iminoethyl)lysine: A Selective Inhibitor of Inducible Nitric Oxide Synthase

1994 • 464 citations

Endothelial NOS and the Blockade of LTP by NOS Inhibitors in Mice Lacking Neuronal NOS

1994 • 422 citations

Nitric oxide, the enigmatic neuronal messenger: its role in synaptic plasticity

1997 • 412 citations

Estrogen Increases Endothelial Nitric Oxide by a Receptor Mediated System

1995 • 403 citations

Cell Membrane and Nuclear Estrogen Receptors (ERs) Originate from a Single Transcript: Studies of ER and ER Expressed in Chinese Hamster Ovary Cells

1999 • 371 citations

Production and physiological actions of anandamide in the vasculature of the rat kidney.

1997 • 363 citations

Why nitric oxide?

1992 • 350 citations

Estrogen and the blood vessel wall

1994 • 316 citations

Role of nitric oxide in the control of luteinizing hormone-releasing hormone release in vivo and in vitro.

1993 • 313 citations

Nongenomic Stimulation of Nitric Oxide Release by Estrogen Is Mediated by Estrogen Receptor α Localized in Caveolae

1999 • 304 citations

Relationship of Neuronal Nitric Oxide Synthase Immunoreactivity to GnRH Neurons in the Ovariectomized and Intact Female Rat

1996 • 290 citations

The Hypothalamic‐Pituitary‐Adrenal Axis and the Female Reproductive System

1997 • 287 citations

Intrinsic pulsatile secretory activity of immortalized luteinizing hormone-releasing hormone-secreting neurons.

1992 • 281 citations

Presence of the μ3 Opiate Receptor in Endothelial Cells

1995 • 276 citations

Generation and synchronization of gonadotropin-releasing hormone (GnRH) pulses: intrinsic properties of the GT1-1 GnRH neuronal cell line.

1992 • 263 citations

Estradiol induces the calcium-dependent translocation of endothelial nitric oxide synthase

1999 • 231 citations

Nitric oxide regulates luteinizing hormone-releasing hormone secretion.

1993 • 225 citations

Nitric Oxide Mediates Leptin-Induced Luteinizing Hormone-Releasing Hormone (LHRH) and LHRH and Leptin-Induced LH Release from the Pituitary Gland

1997 • 224 citations

Nitric oxide mediates norepinephrine-induced prostaglandin E2 release from the hypothalamus.

1992 • 219 citations

Calcium signaling and episodic secretion of gonadotropin-releasing hormone in hypothalamic neurons.

1992 • 204 citations

Estrogen receptor-immunoreactive glia, endothelia, and ependyma in guinea pig preoptic area and median eminence: electron microscopy.

1992 • 198 citations

Continuous Monitoring of Nitric Oxide Release from Human Umbilical Vein Endothelial Cells

1993 • 192 citations

Cannabinoid Receptors Are Coupled to Nitric Oxide Release in Invertebrate Immunocytes, Microglia, and Human Monocytes

1996 • 187 citations

Role of nitric oxide in interleukin 2-induced corticotropin-releasing factor release from incubated hypothalami.

1993 • 184 citations

Cell-Surface Estrogen Receptors Mediate Calcium-Dependent Nitric Oxide Release in Human Endothelia

2000 • 177 citations

Definitive evidence for the existence of morphological plasticity in the external zone of the median eminence during the rat estrous cycle: implication of neuro-glio-endothelial interactions in gonadotropin-releasing hormone release

1999 • 175 citations

Nitric oxide modulates the release of corticotropin-releasing hormone from the rat hypothalamus in vitro

1993 • 173 citations

Involvement of transforming growth factor alpha in the release of luteinizing hormone-releasing hormone from the developing female hypothalamus.

1990 • 169 citations

Morphine-induced conformational changes in human monocytes, granulocytes, and endothelial cells and in invertebrate immunocytes and microglia are mediated by nitric oxide.

1996 • 165 citations

Chronic Estrogen Treatment Increases Levels of Endothelial Nitric Oxide Synthase Protein in Rat Cerebral Microvessels

1999 • 163 citations

Evidence that nitric oxide may mediate the ovarian steroid-induced luteinizing hormone surge: involvement of excitatory amino acids.

1993 • 159 citations

Ependymoneuronal specializations between LHRH fibers and cells of the cerebroventricular system

1985 • 149 citations

Gaseous Transmitters and Neuroendocrine Regulation

1997 • 145 citations

Interleukin-2 (IL-2) induces corticotropin-releasing factor (CRF) release from the amygdala and involves a nitric oxide-mediated signaling; comparison with the hypothalamic response.

1995 • 142 citations

Effects of Hypothalamic Deafferentation on the Pulsatile Rhythm in Plasma Concentrations of Luteinizing Hormone in Ovariectomized Rats¹

1974 • 139 citations

Immunohistochemical mapping of nitric oxide synthase in the rat hypothalamus and colocalization with neuropeptides

1996 • 134 citations

Estradiol Coupling to Endothelial Nitric Oxide Stimulates Gonadotropin-Releasing Hormone Release from Rat Median Eminence Via a Membrane Receptor*

1999 • 115 citations

Estradiol Coupling to Human Monocyte Nitric Oxide Release Is Dependent on Intracellular Calcium Transients: Evidence for an Estrogen Surface Receptor

1999 • 111 citations

Luteinizing hormone-releasing hormone terminals in the median eminence of rats undergo dramatic changes after gonadectomy, as revealed by electron microscopic image analysis.

1994 • 103 citations

Evidence that Brain Nitric Oxide Synthase is the Major Nitric Oxide Synthase Isoform in the Hypothalamus of the Adult Female Rat and that Nitric Oxide Potently Regulates Hypothalamic cGMP Levels

1996 • 100 citations

Autoimmunovascular regulation: morphine and ancondamide and ancondamide stimulated nitric oxide release

1998 • 100 citations

Abnormal Estrous Cyclicity after Disruption of Endothelial and Inducible Nitric Oxide Synthase in Mice

1999 • 99 citations

PUBERTY-RELATED INCREASE IN EPISODIC LHRH RELEASE FROM RAT HYPOTHALAMUSIN VITRO¹

1984 • 95 citations

Estrogen receptor-immunoreactive glia, endothelia, and ependyma in guinea pig preoptic area and median eminence: electron microscopy

1992 • 94 citations

Neuropeptides, nitric oxide synthase and GAP-43 in B4-binding and RT97 immunoreactive primary sensory neurons: normal distribution pattern and changes after peripheral nerve transection and aging

1999 • 94 citations

Nitric Oxide Stimulates ACTH Secretion and the Transcription of the Genes Encoding for NGFI-B, Corticotropin-Releasing Factor, Corticotropin-Releasing Factor Receptor Type 1, and Vasopressin in the Hypothalamus of the Intact Rat

1999 • 89 citations

Nitric oxide synthesized by gonadotropin-releasing hormone neurons is a mediator of N-methyl-D-aspartate (NMDA)-induced GnRH secretion.

1994 • 88 citations

Morphine and anandamide coupling to nitric oxide stimulates GnRH and CRF release from rat median eminence: neurovascular regulation

1998 • 88 citations

Evidence for a Physiological Role for Nitric Oxide in the Regulation of the LH Surge: Effect of Central Administration of Antisense Oligonucleotides to Nitric Oxide Synthase

1996 • 79 citations

Ethanol inhibits luteinizing hormone-releasing hormone (LHRH) secretion by blocking the response of LHRH neuronal terminals to nitric oxide.

1995 • 79 citations

Immunocytochemistry of endothelial nitric oxide synthase in the rat brain: a light and electron microscopical study using the tyramide signal amplification technique

1997 • 78 citations

Nitric oxide inhibits hypothalamic luteinizing hormone-releasing hormone release by releasing gamma-aminobutyric acid.

1995 • 77 citations

Evidence for involvement of nitric oxide in the regulation of hypothalamic portal blood flow

1992 • 76 citations

Evidence in support of nitric oxide (NO) involvement in the cyclic release of prolactin and LH surges

1994 • 76 citations

Nitric oxide synthase content of hypothalamic explants: increase by norepinephrine and inactivated by NO and cGMP.

1996 • 75 citations

Oxytocin stimulates the release of luteinizing hormone-releasing hormone from medial basal hypothalamic explants by releasing nitric oxide

1997 • 71 citations

Prolactin and Growth Hormone Release in Response to Sequential Stimulation by Arginine and Synthetic TRF

1973 • 71 citations

Nitric oxide regulates luteinizing hormone-releasing hormone secretion

1993 • 66 citations

Semi-quantitative ultrastructural analysis of the localization and neuropeptide content of gonadotropin releasing hormone nerve terminals in the median eminence throughout the estrous cycle of the rat

1998 • 65 citations

Human Vascular and Cardiac Endothelia Express Mu Opiate Receptor Transcripts

2000 • 61 citations

Differential expression of neuronal and endothelial nitric oxide synthase in blood vessels of the rat brain

1997 • 60 citations

Nitric Oxide Mediates Leptin-Induced Luteinizing Hormone-Releasing Hormone (LHRH) and LHRH and Leptin-Induced LH Release from the Pituitary Gland

1997 • 59 citations

Detection of endothelial cell-derived nitric oxide: Current trends and future directions

1995 • 54 citations

Prostaglandin E₂-Induced Luteinizing Hormone- Releasing Hormone Release Involves Mobilization of Intracellular Ca⁺²*

1985 • 54 citations

Novel associations among gonadotropin-releasing hormone neurons.

1995 • 53 citations

Evidence that nitric oxide may mediate the ovarian steroid-induced luteinizing hormone surge: involvement of excitatory amino acids

1993 • 53 citations

Reproductive Function in Female Mice Lacking the Gene for Endothelial Nitric Oxide Synthase

1999 • 51 citations

Increased Expression of Nitric Oxide Synthase in Hypothalamic Neuronal Regeneration

1993 • 48 citations

Nitric Oxide Is Involved in the Genesis of Pulsatile LHRH Secretion from Immortalized LHRH Neurons

1997 • 48 citations

Episodic Gonadotropin-Releasing Hormone Release from the Rat Isolated Median Eminence in vitro

1993 • 47 citations

L-arginine/nitric oxide amplifies the magnitude and duration of the luteinizing hormone surge induced by estrogen: involvement of neuropeptide Y.

1996 • 42 citations

Nitric oxide synthase and growth-associated protein are coexpressed in primary sensory neurons after peripheral injury

1999 • 40 citations

Stimulation of Cyclic Adenosine 3′,5′-Monophosphate Production Enhances Hypothalamic Luteinizing Hormone-Releasing Hormone Release without Increasing Prostaglandin E₂Synthesis: Studies in Prepubertal Female Rats*

1985 • 38 citations

Opioid-Glutamate-Nitric Oxide Connection in the Regulation of Luteinizing Hormone Secretion in the Rat*

1998 • 37 citations

Luteinizing hormone-releasing hormone terminals in the median eminence of rats undergo dramatic changes after gonadectomy, as revealed by electron microscopic image analysis

1994 • 36 citations

Synchronized neuronal networks: The GnRH system

1999 • 36 citations

A Comparative Study of the Effects of Nitric Oxide and Carbon Monoxide on the in vivo Release of Gonadotropin-Releasing Hormone and Neuropeptide Y from Rat Hypothalamus during the Estradiol-Induced Luteinizing Hormone Surge: Estimation by Push-Pull Perfusion

1999 • 35 citations

Presence of interleukin-10 transcripts in human pituitary and hypothalamus

1995 • 35 citations

Estradiol Coupling to Endothelial Nitric Oxide Stimulates Gonadotropin-Releasing Hormone Release from Rat Median Eminence Via a Membrane Receptor

1999 • 34 citations

Evidence for the production and action of interleukin-10 in pituitary cells

1994 • 34 citations

Effects of 17β-Estradiol on LH-RH Release from Rat Mediobasal Hypothalamic Slices

1984 • 34 citations

Interleukin-10 stimulation of corticotrophin releasing factor median eminence in rats: evidence for dependence upon nitric oxide production

1998 • 28 citations

Role of Phosphodiesterases in the Regulation of Gonadotropin- Releasing Hormone Secretion in GT1 Cells

1998 • 27 citations

Novel associations among gonadotropin-releasing hormone neurons

1995 • 26 citations

Nitric oxide synthesized by gonadotropin-releasing hormone neurons is a mediator of N-methyl-D-aspartate (NMDA)-induced GnRH secretion

1994 • 26 citations

Mechanisms of Stress on Reproduction: Evidence for a Complex Intra-Hypothalamic Circuit

1998 • 25 citations

Neural regeneration and neuronal migration following injury I. The endocrine hypothalamus and neurohypophyseal system

1995 • 25 citations

Gonadectomy Influences the Inhibitory Effect of the Endogenous Opiate System on Pulsatile Gonadotropin Secretion

1988 • 22 citations

Nitric Oxide Induces Morphological Changes in Cultured Neurohypophysial Astrocytes

1996 • 19 citations

Growth-Associated Protein-43 Messenger Ribonucleic Acid Expression in Gonadotropin-Releasing Hormone Neurons during the Rat Estrous Cycle

2000 • 19 citations

Opioid-Glutamate-Nitric Oxide Connection in the Regulation of Luteinizing Hormone Secretion in the Rat

1998 • 16 citations

L-arginine/nitric oxide amplifies the magnitude and duration of the luteinizing hormone surge induced by estrogen: involvement of neuropeptide Y

1996 • 16 citations

Sodium nitroprusside inhibits the tyrosine hydroxylase activity of the median eminence in the rat

1998 • 12 citations

Growth-Associated Protein-43 Messenger Ribonucleic Acid Expression in Gonadotropin-Releasing Hormone Neurons during the Rat Estrous Cycle

2000 • 8 citations

Inhibition of nitric oxide synthase induces ultrastructural changes in the neurohypophysis of dehydrated rats

1997 • 8 citations

NO news is good news

1994 • 6 citations