Lipid-dependent control of hepatic glycogen stores in healthy humans

Effect of fatty acids on glucose production and utilization in man.

1983 • 1,056 citations

Glucose and free fatty acid metabolism in non-insulin-dependent diabetes mellitus. Evidence for multiple sites of insulin resistance.

1989 • 799 citations

Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study.

1992 • 736 citations

Dose-response characteristics for effects of insulin on production and utilization of glucose in man

1981 • 712 citations

Interaction between glucose and free fatty acid metabolism in human skeletal muscle.

1993 • 476 citations

Contributions of gluconeogenesis to glucose production in the fasted state.

1996 • 470 citations

Role of fatty acids in the pathogenesis of insulin resistance and NIDDM

1997 • 465 citations

Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects.

1999 • 425 citations

Relationships between insulin secretion, insulin action, and fasting plasma glucose concentration in nondiabetic and noninsulin-dependent diabetic subjects.

1984 • 407 citations

Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver.

1966 • 388 citations

Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat.

1996 • 373 citations

The effects of free fatty acids on gluconeogenesis and glycogenolysis in normal subjects

1999 • 298 citations

Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs.

1996 • 290 citations

Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans.

1998 • 231 citations

Glycerol turnover and oxidation in man

1972 • 222 citations

Splanchnic and leg exchange of glucose, amino acids, and free fatty acids during exercise in diabetes mellitus.

1975 • 215 citations

Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM

1988 • 184 citations

Failure of substrate-induced gluconeogenesis to increase overall glucose appearance in normal humans. Demonstration of hepatic autoregulation without a change in plasma glucose concentration.

1990 • 162 citations

Demonstration of a critical role for free fatty acids in mediating counterregulatory stimulation of gluconeogenesis and suppression of glucose utilization in humans.

1993 • 160 citations

The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans.

1996 • 150 citations

The direct and indirect effects of insulin on hepatic glucose production in vivo

1998 • 130 citations

Effect of the antilipolytic nicotinic acid analogue acipimox on whole-body and skeletal muscle glucose metabolism in patients with non-insulin-dependent diabetes mellitus.

1991 • 124 citations

Contribution of net hepatic glycogenolysis to glucose production during the early postprandial period

1996 • 124 citations

Glycerol gluconeogenesis in fasting humans.

1995 • 104 citations

Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells

1999 • 96 citations

Contributions of net hepatic glycogenolysis and gluconeogenesis to glucose production in cirrhosis

1999 • 93 citations

Artificial induction of intravascular lipolysis by lipid-heparin infusion leads to insulin resistance in man

1988 • 86 citations

Insulin production rate, hepatic insulin retention and splanchnic carbohydrate metabolism after oral glucose ingestion in hyperinsulinaemic Type 2 (non-insulin-dependent) diabetes mellitus

1982 • 81 citations

Effects of a 48-h fat infusion on insulin secretion and glucose utilization

1995 • 77 citations

In vitro and in vivo suppression of gluconeogenesis by inhibition of pyruvate carboxylase

1997 • 77 citations

The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog

1997 • 49 citations

A critical evaluation of mass isotopomer distribution analysis of gluconeogenesis in vivo

1999 • 49 citations

Role of fat-derived substrates in the regulation of gluconeogenesis during fasting

1996 • 42 citations

Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans

1997 • 41 citations

Mechanism of regulation of glucose production by lipolysis in humans

1992 • 35 citations

Origins of the hydrogen bound to carbon 1 of glucose in fasting: significance in gluconeogenesis quantitation

1999 • 35 citations

Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects

1987 • 35 citations

Effects of a high-fat diet and voluntary wheel running on gluconeogenesis and lipolysis in rats

1999 • 35 citations

Effects of lipid on basal carbohydrate metabolism in normal men

1991 • 33 citations

Lipolysis and gluconeogenesis from glycerol are increased in patients with noninsulin-dependent diabetes mellitus

1992 • 32 citations

Enhancement of hepatic glycogen by gluconeogenic precursors: substrate flux or metabolic control?

1990 • 27 citations

Metabolic effects of suppression of nonesterified fatty acid levels with acipimox in obese NIDDM subjects

1992 • 24 citations

Bedtime insulin for suppression of overnight free-fatty acid, blood glucose, and glucose production in NIDDM

1989 • 21 citations

Hepatic glucose-6-phosphatase flux and glucose phosphorylation, cycling, irreversible disposal, and net balance in vivo in rats. Measurement using the secreted glucuronate technique

1997 • 15 citations

Evidence for dual control mechanism regulating hepatic glucose output in nondiabetic men

1991 • 13 citations

Direct analysis of 18O in glucose by mass spectrometry☆

1973 • 13 citations