Self-reactive T cells in murine lupus: Analysis of genetic contributions and development of self-tolerance

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 • 1,711 citations

Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains.

1978 • 1,619 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

The Immunology and Pathology of NZB Mice

1968 • 664 citations

Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4.

1985 • 466 citations

A T cell receptor Vβ segment that imparts reactivity to a class II major histocompatibility complex product

1987 • 408 citations

Effects of thymectomy or androgen administration upon the autoimmune disease of MRL/Mp-lpr/lpr mice.

1980 • 331 citations

The MHC molecule I-E is necessary but not sufficient for the clonal deletion of V beta 11-bearing T cells.

1989 • 331 citations

Abnormalities induced by the mutant gene Ipr: expansion of a unique lymphocyte subset.

1982 • 295 citations

T cells can distinguish between allogeneic major histocompatibility complex products on different cell types

1988 • 246 citations

The contribution of L3T4+ T cells to lymphoproliferation and autoantibody production in MRL-lpr/lpr mice.

1988 • 232 citations

Treatment of (NZB x NZW)F1 disease with anti-I-A monoclonal antibodies.

1983 • 208 citations

Molecular clones of the mouse t complex derived from microdissected metaphase chromosomes

1984 • 197 citations

Dispersion of α-like globin genes of the mouse to three different chromosomes

1981 • 171 citations

The contribution of NZW genes to lupus-like disease in (NZB x NZW)F1 mice.

1987 • 146 citations

Deletion of potentially self-reactive T cell receptor specificities in L3T4-, Lyt-2- T cells of lpr mice.

1988 • 142 citations

Influence of thymic genotype on the systemic lupus erythematosus-like disease and T cell proliferation of MRL/Mp-lpr/lpr mice.

1981 • 128 citations

The proliferating cells in autoimmune MRL/lpr mice lack L3T4, an antigen on "helper" T cells that is involved in the response to class II major histocompatibility antigens.

1984 • 128 citations

Pathological changes of thymic epithelial cells and autoimmune disease in NZB, NZW and (NZB x NZW)F1 mice.

1967 • 121 citations

A Large Deletion Within the T-Cell Receptor Beta-Chain Gene Complex in New Zealand White Mice

1985 • 105 citations

The immunobiology of the T cell response to Mls-locus-disparate stimulator cells. I. Unidirectionality, new strain combinations, and the role of Ia antigens.

1985 • 85 citations

Biology of the mouse histocompatibility-2 complex;: Principles of immunogenetics applied to a single system

1975 • 82 citations

The lymphoproliferating cells of MRL‐lpr/lpr mice are a polyclonal population that bear the T lymphocyte receptor for antigen

1985 • 80 citations

Delineation of a defect in T cell receptor beta genes of NZW mice predisposed to autoimmunity.

1986 • 68 citations

T cell lineages in the thymus of lpr/lpr mice. Evidence for parallel pathways of normal and abnormal T cell development.

1987 • 66 citations

Age-Dependent Loss in New Zealand Mice of Morphological and Functional Characteristics of Thymic Epithelial Cells

1978 • 64 citations

Genetic regulation of the class conversion of dsDNA-specific antibodies in (NZB � NZW)F1 hybrid

1983 • 55 citations

Isolation and analysis of genomic DNA clones encoding the third component of mouse complement.

1982 • 51 citations

Abnormal expression of T cell receptor genes in Lyt-2- L3T4- lymphocytes of lpr mice: comparison with normal immature thymocytes.

1987 • 51 citations

T cell tolerance to self antigens in New Zealand hybrid mice with lupus-like disease.

1989 • 39 citations