Review Article Imiquimod applied topically: a novel immune response modifier and new class of drug

Epidemiology of Genital Human Papillomavirus Infection

1997 • 1,122 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

Selective Expression of an Interleukin-12 Receptor Component by Human T Helper 1 Cells

1997 • 783 citations

Self-administered Topical 5% Imiquimod Cream for External Anogenital Warts

1998 • 558 citations

Immunological Events in Regressing Genital Warts

1994 • 490 citations

Treatment of genital warts with an immune-response modifier (imiquimod)

1998 • 308 citations

Imiquimod, a Topical Immune Response Modifier, Induces Migration of Langerhans Cells11The authors have declared a conflict of interest.

2000 • 295 citations

Cytokine induction by the immunomodulators imiquimod and S-27609

1995 • 268 citations

A Randomized, Controlled, Molecular Study of Condylomata Acuminata Clearance during Treatment with Imiquimod

1998 • 255 citations

Imiquimod, a Patient-Applied Immune-Response Modifier for Treatment of External Genital Warts

1998 • 228 citations

Influenza: Its Control in Persons and Populations

1986 • 177 citations

Inhibition of murine tumor growth by an interferon-inducing imidazoquinolinamine.

1992 • 174 citations

Cytokine induction in mice by the immunomodulator imiquimod

1994 • 173 citations

Cytokine Induction in Hairless Mouse and Rat Skin After Topical Application of the Immune Response Modifiers Imiquimod and S-28463

1998 • 173 citations

Modification of immunological responses and clinical disease during topical R-837 treatment of genital HSV-2 infection

1988 • 158 citations

Cellular Requirements for Cytokine Production in Response to the Immunomodulators Imiquimod and S-27609

1995 • 140 citations

Stimulation of Interferon and Cytokine Gene Expression by Imiquimod and Stimulation by Sendai Virus Utilize Similar Signal Transduction Pathways

1995 • 137 citations

Effects of a novel topical immunomodulator, imiquimod, on keratinocyte cytokine gene expression.

1994 • 116 citations

Imiquimod 5% cream (Aldara™)

1998 • 115 citations

A phase I clinical trial of imiquimod, an oral interferon inducer, administered daily

1996 • 107 citations

Posttherapy suppression of genital herpes simplex virus (HSV) recurrences and enhancement of HSV-specific T-cell memory by imiquimod in guinea pigs

1994 • 105 citations

Induction of Interferon and Other Cytokines by Imiquimod and Its Hydroxylated Metabolite R-842 in Human Blood Cells In Vitro

1994 • 105 citations

Efficacy of S26308 against guinea pig cytomegalovirus infection

1988 • 84 citations

Effects of the immunomodulating agent R837 on acute and latent herpes simplex virus type 2 infections

1989 • 80 citations

INDUCTION OF CYTOKINES IN CYNOMOLGUS MONKEYS BY THE IMMUNE RESPONSE MODIFIERS, IMIQUIMOD, S-27609 AND S-28463

1997 • 77 citations

Phase I trial of an oral immunomodulator and interferon inducer in cancer patients.

1993 • 73 citations

Administration of Imiquimod, an Interferon Inducer, in Asymptomatic Human Immunodeficiency Virus‐Infected Persons to Determine Safety and Biologic Response Modification

1998 • 68 citations

Adjuvant Effects of Imiquimod on a Herpes Simplex Virus Type 2 Glycoprotein Vaccine in Guinea Pigs

1993 • 60 citations

Activation of Local Cell-Mediated Immunity in Interferon-Responsive Patients with Human Papillomavirus-Associated Lesions

1996 • 59 citations

Effect of imiquimod as an adjuvant for immunotherapy of genital HSV in guinea-pigs

1995 • 48 citations

Loss of (2'-5')oligoadenylate synthetase activity by production of antisense RNA results in lack of protection by interferon from viral infections.

1987 • 45 citations

Bovine respiratory disease : a symposium

1984 • 45 citations

Effects of therapy with an immunomodulator (imiquimod, R-837) alone and with acyclovir on genital HSV-2 infection in guinea-pigs when begun after lesion development

1993 • 41 citations

Primary tissue culture of spontaneously regressing flat warts.In vitro attack by mononuclear cells against wart-derived epidermal cells

1985 • 35 citations

Effects of cytokines and R-837, a cytokine inducer, on UV-irradiation augmented recurrent genital herpes in guinea pigs

1991 • 30 citations

Attenuation of virus-induced airway dysfunction in rats treated with imiquimod

1998 • 23 citations

Epidemiology of genital human papillomavirus infections

1997 • 18 citations

Imiquimod: In Vivo and In Vitro Characteristics and Toxicology

1997 • 14 citations

Imiquimod, a novel topical immune response modifier induces migration of langerhans cells

1998 • 7 citations

Effects of the imidazoquinolines, imiquimod and S-28463, on TH1 and TH2 cytokine responses in vitro

1998 • 4 citations

Safety and efficacy of imiquimod 5% cream for the treatment of bowen's disease

1998 • 4 citations

P333 A safety assessment of topical imiquimod

1997 • 1 citations

Deleted Work

1955 • 0 citations