Human autologous mixed lymphocyte reaction as an in vitro model for autoreactivity to apoptotic antigens

Improved silver staining of plant proteins, RNA and DNA in polyacrylamide gels

1987 • 4,186 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

1994 • 1,722 citations

Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus

1998 • 825 citations

Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus.

1993 • 637 citations

Accelerated in vitro apoptosis of lymphocytes from patients with systemic lupus erythematosus.

1994 • 555 citations

Cleavage by Granzyme B Is Strongly Predictive of Autoantigen Status

1999 • 484 citations

DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis.

1995 • 422 citations

Autologous stimulation of human lymphocyte subpopulation.

1975 • 323 citations

Visualization, characterization, and turnover of CD8+ memory T cells in virus-infected hosts.

1996 • 259 citations

Increased apoptotic peripheral blood neutrophils in systemic lupus erythematosus: relations with disease activity, antibodies to double stranded DNA, and neutropenia

1999 • 228 citations

Nucleosomal peptide epitopes for nephritis-inducing T helper cells of murine lupus.

1996 • 221 citations

Posttranslational protein modifications, apoptosis, and the bypass of tolerance to autoantigens

1998 • 197 citations

Nucleosomes are major T and B cell autoantigens in systemic lupus erythematosus

2000 • 191 citations

Circulating plasma levels of nucleosomes in patients with systemic lupus erythematosus. Correlation with serum antinucleosome antibody titers and absence of clear association with disease activity

1997 • 182 citations

Calpain activation is upstream of caspases in radiation-induced apoptosis

1998 • 181 citations

Histone‐specific Th0 and Th1 clones derived from systemic lupus erythematosus patients induce double‐stranded DNA antibody production

1997 • 141 citations

Immunogenic DNA-related factors. Nucleosomes spontaneously released from normal murine lymphoid cells stimulate proliferation and immunoglobulin synthesis of normal mouse lymphocytes.

1990 • 112 citations

Circulating DNA in systemic lupus erythematosus. Isolation and characterization.

1984 • 95 citations

Clearing the way to mechanisms of autoimmunity

2001 • 91 citations

Autologous mixed lymphocyte reaction in man

1981 • 78 citations

Autologous Mixed Lymphocyte Reaction in Man

1982 • 72 citations

Initiation of the Autologous Mixed Lymphocyte Reaction Requires the Expression of Costimulatory Molecules B7-1 and B7-2 on Human Peripheral Blood Dendritic Cells

1998 • 65 citations

Leukemia-Associated Antigens in the Mixed Leukocyte Culture Test

1969 • 64 citations

The role of apoptosis in autoimmunity: immunogen, antigen, and accelerant.

1999 • 56 citations

Surface molecules involved in self-recognition and T cell activation in the autologous mixed lymphocyte reaction.

1984 • 55 citations

On the TRAIL from p53 to apoptosis?

1997 • 52 citations

Involvement of ICE (Caspase) Family in γ‐Radiation‐Induced Apoptosis of Normal B Lymphocytes

1997 • 24 citations

Failure of the human autologous mixed lymphocyte reaction in the absence of foreign antigens

1983 • 21 citations

The suppressive effects of monocytes in the autologous mixed lymphocyte reaction.

1981 • 15 citations