Nucleosomes are major T and B cell autoantigens in systemic lupus erythematosus

The 1982 revised criteria for the classification of systemic lupus erythematosus

1982 • 14,553 citations

Preliminary criteria for the classification of systemic sclerosis (scleroderma)

1980 • 4,703 citations

Derivation of the sledai. A disease activity index for lupus patients

1992 • 4,410 citations

Preliminary criteria for the classification of Sjögren's syndrome. Results of a prospective concerted action supported by the European community

1993 • 1,438 citations

Autoantibodies to Nuclear Antigens (ANA): Their Immunobiology and Medicine

1982 • 975 citations

Systemic Lupus Erythematosus

1996 • 677 citations

Nucleosome: a major immunogen for pathogenic autoantibody-inducing T cells of lupus.

1993 • 637 citations

T cell receptor alpha/beta expressing double-negative (CD4-/CD8-) and CD4+ T helper cells in humans augment the production of pathogenic anti-DNA autoantibodies associated with lupus nephritis.

1989 • 402 citations

Disease activity in systemic lupus erythematosus: report of the Consensus Study Group of the European Workshop for Rheumatology Research. II. Identification of the variables indicative of disease activity and their use in the development of an activity score. The European Consensus Study Group for Disease Activity in SLE.

1992 • 320 citations

The central role of chromatin in autoimmune responses to histones and DNA in systemic lupus erythematosus.

1994 • 307 citations

A novel epitope on the C-terminus of SmD1 is recognized by the majority of sera from patients with systemic lupus erythematosus.

1998 • 288 citations

Somatic mutations in the variable regions of a human IgG anti-double-stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosus.

1991 • 246 citations

Analysis of immunoglobulin variable region genes from human IgG anti‐DNA hybridomas

1992 • 238 citations

Genesis and evolution of antichromatin autoantibodies in murine lupus implicates T-dependent immunization with self antigen.

1993 • 234 citations

Nucleosome‐restricted antibodies are detected before anti‐dsdna and/or antihistone antibodies in serum of mrl‐mp lpr/lpr and +/+ mice, and are present in kidney eluates of lupus mice with proteinuria

1994 • 207 citations

Interleukin-10 promotes activation-induced cell death of SLE lymphocytes mediated by Fas ligand.

1997 • 178 citations

Major peptide autoepitopes for nucleosome-specific T cells of human lupus

1999 • 167 citations

Structure and specificity of T cell receptors expressed by potentially pathogenic anti-DNA autoantibody-inducing T cells in human lupus.

1995 • 165 citations

The key role of nucleosomes in lupus

1999 • 162 citations

Presence of nucleosome‐restricted antibodies in patients with systemic lupus erythematosus

1995 • 144 citations

Histone‐specific Th0 and Th1 clones derived from systemic lupus erythematosus patients induce double‐stranded DNA antibody production

1997 • 141 citations

Nucleosomes and histones are present in glomerular deposits in human lupus nephritis

1997 • 139 citations

Are there unique autoantigens triggering autoimmune diseases?

1998 • 87 citations

Promiscuous Presentation and Recognition of Nucleosomal Autoepitopes in Lupus: Role of Autoimmune T Cell Receptor α Chain

1998 • 84 citations

Homology of the NH2-terminal amino acid sequences of the heavy and light chains of human monoclonal lupus autoantibodies containing the dominant 16/6 idiotype.

1985 • 79 citations

Lymphocyte apoptosis in systemic lupus erythematosus: relationships with Fas expression, serum soluble Fas and disease activity

1999 • 69 citations

Current concepts in the classification of connective tissue diseases

1980 • 64 citations

Antibodies to histone (h2a–h2b)–dna complexes in the absence of antibodies to double‐stranded dna or to (h2a–h2b) complexes are more sensitive and specific for scleroderma‐related disorders than for lupus

1994 • 56 citations

Alterations in immune function following head injury in children

1995 • 52 citations

Penetrating Anti-DNA Monoclonal Antibodies Induce Activation of Human Peripheral Blood Mononuclear Cells

1998 • 48 citations

Do Elevated Levels of Serum-Soluble Fas Contribute to the Persistence of Activated Lymphocytes in Systemic Lupus Erythematosus?

1998 • 35 citations

p205 is a major target of autoreactive T cells in rheumatoid arthritis

1999 • 34 citations

Chronicity of Arthritis Induced with Homologous Type II Collagen (CII) in Rats is Associated with Anti-CII B-cell Activation

1994 • 32 citations

Rheumatoid arthritis: autoreactive T cells recognising a novel 68k autoantigen

1997 • 28 citations

Anti-DNA, Anti-Deoxyribonucleoprotein and Rheumatoid Factor Measured by ELISA in Patients with Systemic Lupus Erythematosus, Sjögren’s Syndrome and Rheumatoid Arthritis

1982 • 26 citations

Immunochemical Determination of DNA in Immune Complexes Present in the Circulation of Patients with Systemic Lupus Erythematosus

1998 • 22 citations

SYSTEMIC LUPUS ERYTHEMATOSUS

2023 • 11 citations

Deleted Work

1955 • 0 citations