Effects of different inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, pravastatin sodium and simvastatin, on sterol synthesis and immunological functions in human lymphocytes in vitro

Isolation of mononuclear cells and granulocytes from human blood.

1968 • 9,672 citations

In vitro methods in cell-mediated and tumor immunity

1976 • 1,266 citations

ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogensis produced by Penicillium citrinum.

1976 • 926 citations

CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species

1986 • 376 citations

Interferon-gamma inhibits scavenger receptor expression and foam cell formation in human monocyte-derived macrophages.

1992 • 264 citations

Relative Lipophilicities, Solubilities, and Structure–Pharmacological Considerations of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Inhibitors Pravastatin, Lovastatin, Mevastatin, and Simvastatin

1991 • 199 citations

Tissue-selective inhibition of cholesterol synthesis in vivo by pravastatin sodium, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor

1990 • 171 citations

T lymphocytes inhibit the vascular response to injury.

1991 • 152 citations

Europium-labelled target cells in an assay of natural killer cell activity

1986 • 130 citations

Suppression of lymphoid cell function in vitro by inhibition of 3-hydroxy-3-methylglutaryl coenzyme a reductase by lovastatin

1989 • 68 citations

Tissue selectivity of pravastatin sodium, lovastatin and simvastatin. The relationship between inhibition of de novo sterol synthesis and active drug concentrations in the liver, spleen and testis in rat

1992 • 62 citations

Sterol metabolism and lymphocyte responsiveness: inhibition of endogenous sterol synthesis prevents mitogen-induced human T cell proliferation.

1981 • 57 citations

Inhibition by 6-fluoromevalonate demonstrates that mevalonate or one of the mevalonate phosphates is necessary for lymphocyte proliferation.

1990 • 52 citations

Immune surveillance and natural resistance: an evaluation

1986 • 36 citations

Interferon-γ suppresses PDGF production from THP-1 cells and blood monocyte-derived macrophages

1992 • 22 citations

Drugs of abuse, immunity, and immunodeficiency

1992 • 20 citations

Identification of a new surface molecule expressed by human LGL and LAK cells: Production of a specific monoclonal antibody and comparison with other NK/LAK markers

1989 • 12 citations

Isoprenoid Formation and Cell-Mediated Immunological Functions

1991 • 6 citations

Phorbol esters inhibit the functional activation of cytotoxic precursors in mixed lymphocyte cultures.

1984 • 4 citations

Modulation of the immune response to tumors by a novel synthetic compound, (4R)-3-benzoyl-N-[(1R)-1-phenylethyl]-4-thiazolidinecarboxamide (RS-0481)

1991 • 3 citations

Development of Specific Antisera against 9-Desglycinamide-8- Arginine Vasopressin by Site-Specific Immunization

1991 • 2 citations