Immunologic effects of combined protease inhibitor and reverse transcriptase inhibitor therapy in previously treated chronic HIV-1 infection

Positive Effects of Combined Antiretroviral Therapy on CD4 ⁺ T Cell Homeostasis and Function in Advanced HIV Disease

1997 • 1,812 citations

THE MULTICENTER AIDS COHORT STUDY: RATIONALE, ORGANIZATION, AND SELECTED CHARACTERISTICS OF THE PARTICIPANTS

1987 • 1,150 citations

Clonal populations of T cells in normal elderly humans: the T cell equivalent to "benign monoclonal gammapathy".

1994 • 788 citations

Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation

1998 • 722 citations

Rapid and simple PCR assay for quantitation of human immunodeficiency virus type 1 RNA in plasma: application to acute retroviral infection

1994 • 576 citations

Elevated CD38 Antigen Expression on CD8+ T Cells Is a Stronger Marker for the Risk of Chronic HIV Disease Progression to AIDS and Death in the Multicenter AIDS Cohort Study Than CD4+ Cell Count, Soluble Immune Activation Markers, or Combinations of HLA-DR and CD38 Expression

1997 • 551 citations

HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies

1997 • 527 citations

CD8 naive T cell counts decrease progressively in HIV-infected adults.

1995 • 495 citations

Elevated levels of CD38+ CD8+ T cells in HIV infection add to the prognostic value of low CD4+ T cell levels: results of 6 years of follow-up. The Los Angeles Center, Multicenter AIDS Cohort Study.

1993 • 452 citations

Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis

1996 • 452 citations

Immunologic Responses Associated with 12 Weeks of Combination Antiretroviral Therapy Consisting of Zidovudine, Lamivudine, and Ritonavir: Results of AIDS Clinical Trials Group Protocol 315

1998 • 431 citations

Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts.

1996 • 378 citations

Alterations in the Immune Response of Human Immunodeficiency Virus (HIV)-Infected Subjects Treated with an HIV-Specific Protease Inhibitor, Ritonavir

1996 • 338 citations

T-cell subset alterations in HIV-infected homosexual men: NIAID multicenter AIDS cohort study

1989 • 297 citations

Immunopathogenic Mechanisms in Human Immunodeficiency Virus (HIV) Infection

1991 • 273 citations

Quantitative changes in T helper or T suppressor/cytotoxic lymphocyte subsets that distinguish acquired immune deficiency syndrome from other immune subset disorders

1984 • 272 citations

Anergy and apoptosis in CD8+ T cells from HIV-infected persons.

1994 • 252 citations

Circulating HIV-specific CD8+ cytotoxic T cells express CD38 and HLA-DR antigens.

1993 • 239 citations

CD8+ T-Lymphocyte Activation in HIV-1 Disease Reflects an Aspect of Pathogenesis Distinct From Viral Burden and Immunodeficiency

1998 • 234 citations

Cd8+ Lymphocyte Activation At Human Immunodeficiency Virus Type 1 Seroconversion: Development Of Hla-Dr+ Cd38- Cd8+ Cells Is Associated With Subsequent Stable Cd4+ Cell Levels

1994 • 189 citations

FACTORS ASSOCIATED WITH PREVALENT HUMAN IMMUNODEFICIENCY VIRUS (HIV) INFECTION IN THE MULTICENTER AIDS COHORT STUDY

1987 • 188 citations

Expression of activation antigens, HLA-DR and CD38, on CD8 lymphocytes during HIV-1 infection

1992 • 182 citations

Virus Burden in Long-Term Survivors of Human Immunodeficiency Virus (HIV) Infection Is a Determinant of Anti-HIV CD8+ Lymphocyte Activity

1995 • 157 citations

Expression of Costimulatory Molecule CD28 on T Cells in Human Immunodeficiency Virus Type 1 Infection: Functional and Clinical Correlations

1994 • 156 citations

Clonal expansion within the CD4+CD57+ and CD8+CD57+ T cell subsets in chronic lymphocytic leukemia.

1997 • 154 citations

Seroconversion, sexual activity, and condom use among 2915 HIV seronegative men followed for up to 2 years.

1989 • 127 citations

Subsets of CD8+, CD57+ cells in normal, healthy individuals: correlations with human cytomegalovirus (HCMV) carrier status, phenotypic and functional analyses

1993 • 111 citations

Expression of the fas antigen in patients infected with human immunodeficiency virus

1995 • 85 citations

Correlation of CD8 Lymphocyte Activation with Cellular Viremia and Plasma HIV RNA Levels in Asymptomatic Patients Infected by Human Immunodeficiency Virus Type 1

1996 • 80 citations

Role of apoptosis in HIV disease pathogenesis

1995 • 79 citations

An Approach to the Validation of Markers for Use in AIDS Clinical Trials

1997 • 76 citations

Three-color cytofluorometric analysis of CD8 cell subsets in HIV-1 infection.

1991 • 73 citations

Lymphocyte activation in HIV-1 infection. I. Predominant proliferative defects among CD45RO+ cells of the CD4 and CD8 lineages

1993 • 56 citations

Expression of CD28 on CD8⁺ and CD4⁺ Lymphocytes During HIV Infection

1994 • 49 citations

Major Expansions of Select CD8⁺Subsets in Acute Epstein‐Barr Virus Infection: Comparison with Chronic Human Immunodeficiency Virus Disease

1998 • 47 citations

The Effect of Zidovudine Treatment on Serum Neopterin and ??2-Microglobulin Levels in Mildly Symptomatic, HIV Type 1 Seropositive Individuals

1992 • 43 citations

Eleven lymphoid phenotypic markers in HIV infection: selective changes induced by zidovudine treatment.

1992 • 33 citations

Phenotypically defined memory CD4+ cells are not selectively decreased in chronic HIV disease.

1994 • 33 citations

Characterization of T Lymphocyte Subset Alterations by Flow Cytometry in HIV Disease

1993 • 32 citations

The Impaired in Vitro Production of Interleukin-2 in HIV Infection Is Negatively Correlated to the Number of Circulating CD4+ DR+ T Cells and Is Reversed by Allowing T Cells to Rest in Culture: Arguments for in Vivo CD4+ T Cell Activation

1993 • 23 citations