Correlation of CD8 Lymphocyte Activation with Cellular Viremia and Plasma HIV RNA Levels in Asymptomatic Patients Infected by Human Immunodeficiency Virus Type 1

A simple method of estimating 50 per cent end points

1938 • 8,381 citations

HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease

1993 • 1,822 citations

Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS

1993 • 1,450 citations

High Levels of HIV-1 in Plasma During All Stages of Infection Determined By Competitive PCR

1993 • 1,263 citations

Quantitation of Human Immunodeficiency Virus Type 1 in the Blood of Infected Persons

1989 • 1,090 citations

CD8 ⁺ Lymphocytes Can Control HIV Infection in Vitro by Suppressing Virus Replication

1986 • 1,010 citations

Transient High Levels of Viremia in Patients with Primary Human Immunodeficiency Virus Type 1 Infection

1991 • 851 citations

HIV-specific cytotoxic T lymphocytes in seropositive individuals

1987 • 797 citations

High Titers of Cytopathic Virus in Plasma of Patients with Symptomatic Primary HIV-1 Infection

1991 • 697 citations

Role of the CD28 receptor in T-cell activation

1990 • 684 citations

Plasma Viremia in Human Immunodeficiency Virus Infection

1989 • 575 citations

Increased viral burden and cytopathicity correlate temporally with CD4+ T-lymphocyte decline and clinical progression in human immunodeficiency virus type 1-infected individuals

1993 • 464 citations

Elevated levels of CD38+ CD8+ T cells in HIV infection add to the prognostic value of low CD4+ T cell levels: results of 6 years of follow-up. The Los Angeles Center, Multicenter AIDS Cohort Study.

1993 • 452 citations

Human CD38: a glycoprotein in search of a function

1994 • 360 citations

Lymphocyte subset reference ranges in adult caucasians

1991 • 305 citations

T-cell subset alterations in HIV-infected homosexual men: NIAID multicenter AIDS cohort study

1989 • 297 citations

Increasing Viral Burden in CD4+ T Cells from Patients with Human Immunodeficiency Virus (HIV) Infection Reflects Rapidly Progressive Immunosuppression and Clinical Disease

1990 • 281 citations

Circulating HIV-specific CD8+ cytotoxic T cells express CD38 and HLA-DR antigens.

1993 • 239 citations

Failure of T-cell homeostasis preceding AIDS in HIV-1 infection

1995 • 235 citations

Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28− T cells

1994 • 215 citations

CD8+ T cells inhibit HIV replication in naturally infected CD4+ T cells. Evidence for a soluble inhibitor.

1990 • 196 citations

An Activated CD8+ T Cell Phenotype Correlates with Anti-HIV Activity and Asymptomatic Clinical Status

1993 • 189 citations

Cd8+ Lymphocyte Activation At Human Immunodeficiency Virus Type 1 Seroconversion: Development Of Hla-Dr+ Cd38- Cd8+ Cells Is Associated With Subsequent Stable Cd4+ Cell Levels

1994 • 189 citations

Expression of activation antigens, HLA-DR and CD38, on CD8 lymphocytes during HIV-1 infection

1992 • 182 citations

Application OF Branched DNA Signal Amplification to Monitor Human Immunodeficiency Virus Type 1 Burden in Human Plasma

1994 • 175 citations

The significance of activation markers on CD8 lymphocytes in human immunodeficiency syndrome: staging and prognostic value

1992 • 174 citations

CD28 is an inducible T cell surface antigen that transduces a proliferative signal in CD3+ mature thymocytes.

1990 • 173 citations

Selective increase of activation antigens HLA-DR and CD38 on CD45RO+ T lymphocytes during HIV-1 infection

1994 • 171 citations

Viral DNA and mRNA expression correlate with the stage of human immunodeficiency virus (HIV) type 1 infection in humans: evidence for viral replication in all stages of HIV disease

1992 • 166 citations

Kinetics of human immunodeficiency virus type 1 (HIV-1) DNA and RNA synthesis during primary HIV-1 infection.

1993 • 133 citations

High-Level Viremia in Adults and Children Infected with Human Immunodeficiency Virus: Relation to Disease Stage and CD4+ Lymphocyte Levels

1991 • 127 citations

Downregulation of CD28 surface antigen on CD4+ and CD8+ T lymphocytes during HIV-1 infection.

1994 • 113 citations

Alterations in cytotoxic and phenotypic subsets of natural killer cells in acquired immune deficiency syndrome (AIDS)

1987 • 101 citations

Evaluation of proviral copy number and plasma RNA level as early indicators of progression in HIV-1 infection

1994 • 80 citations

Three-color cytofluorometric analysis of CD8 cell subsets in HIV-1 infection.

1991 • 73 citations

T Cell Activation in Pediatric AIDS Pathogenesis: Three-Color Immunophenotyping

1994 • 72 citations

Dynamics of molecular parameters of human immunodeficiency virus type 1 activity in vivo

1994 • 69 citations

Review: Class II molecules of the major histocompatibility complex considered as differentiation markers

1986 • 60 citations

Abnormality of Leu 2+7+ cells in acquired immune deficiency syndrome (AIDS), AIDS-related complex, and asymptomatic homosexuals

1986 • 54 citations

Quantitation of Human Immunodeficiency Virus Provirus and Circulating Virus: Relationship with Immunologic Parameters

1992 • 53 citations

Lymphocyte subset analysis to predict progression to AIDS in a cohort of homosexual men in San Francisco

1989 • 49 citations

Functional expression of CD28 on T cell antigen receptor γ/δ‐bearing T lymphocytes

1989 • 41 citations

Quantification and comparison of HIV-1 proviral load in peripheral blood mononuclear cells and isolated CD4+ T cells.

1993 • 40 citations

Comparative Assessment of Quantitative HIV Viraemia Assays

1992 • 39 citations

Human Immunodeficiency Virus Type 1 (HIV-l) Genomic Sequences and Distinct Changes in CD8+ Lymphocytes Precede Detectable Levels of HIV-l Antibodies in High-Risk Homosexuals

1991 • 23 citations