Cell‐cell interactions in regulating osteogenesis and osteoblast function

Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density

1997 • 5,058 citations

Cell Adhesion: The Molecular Basis of Tissue Architecture and Morphogenesis

1996 • 3,454 citations

Osteoblastic cells regulate the haematopoietic stem cell niche

2003 • 3,370 citations

Identification of the haematopoietic stem cell niche and control of the niche size

2003 • 2,900 citations

Convergence of Wnt, ß-Catenin, and Cadherin Pathways

2004 • 2,451 citations

Inhibition of Adipogenesis by Wnt Signaling

2000 • 1,822 citations

Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand

1999 • 1,621 citations

Connexin 26 mutations in hereditary non-syndromic sensorineural deafness

1997 • 1,435 citations

Cardiac Malformation in Neonatal Mice Lacking Connexin43

1995 • 1,242 citations

Structural and Functional Diversity of Connexin Genes in the Mouse and Human Genome

2002 • 1,157 citations

Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions

2003 • 1,127 citations

Connexin Mutations in X-Linked Charcot-Marie-Tooth Disease

1993 • 1,055 citations

OSTEOBLASTIC CELLS ARE INVOLVED IN OSTEOCLAST FORMATION

1988 • 943 citations

BMP-2 Controls Alkaline Phosphatase Expression and Osteoblast Mineralization by a Wnt Autocrine Loop

2003 • 747 citations

Regulation of Wnt Signaling during Adipogenesis

2002 • 712 citations

Developmental Defects in Mouse Embryos Lacking N-Cadherin

1997 • 712 citations

Connexin 43 (GJA1) Mutations Cause the Pleiotropic Phenotype of Oculodentodigital Dysplasia

2003 • 613 citations

Regulation of E-cadherin/Catenin Association by Tyrosine Phosphorylation

1999 • 589 citations

The effects of connexin phosphorylation on gap junctional communication

2003 • 581 citations

The Wnt signalling pathway

2002 • 534 citations

Transforming Growth Factor-β-mediated Chondrogenesis of Human Mesenchymal Progenitor Cells Involves N-cadherin and Mitogen-activated Protein Kinase and Wnt Signaling Cross-talk

2003 • 469 citations

Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain

1992 • 394 citations

Connexin43 Deficiency Causes Delayed Ossification, Craniofacial Abnormalities, and Osteoblast Dysfunction

2000 • 393 citations

Mutations of theConnexin43Gap-Junction Gene in Patients with Heart Malformations and Defects of Laterality

1995 • 376 citations

Regulation of connexin 43-mediated gap junctional intercellular communication by Ca2+ in mouse epidermal cells is controlled by E-cadherin.

1991 • 366 citations

Inhibition of gap junction and adherens junction assembly by connexin and A-CAM antibodies.

1992 • 351 citations

Transduction of Cell Survival Signals by Connexin-43 Hemichannels

2002 • 332 citations

p120 Catenin-Associated Fer and Fyn Tyrosine Kinases Regulate β-Catenin Tyr-142 Phosphorylation and β-Catenin-α-Catenin Interaction

2003 • 329 citations

Binding to cadherins antagonizes the signaling activity of beta-catenin during axis formation in Xenopus.

1996 • 322 citations

Cadherins and tissue formation: integrating adhesion and signaling

1999 • 318 citations

VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts

2002 • 303 citations

Molecular cloning and characterization of OB-cadherin, a new member of cadherin family expressed in osteoblasts.

1994 • 274 citations

Heteromeric connexons in lens gap junction channels.

1996 • 273 citations

Activated β-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction

2003 • 259 citations

Gap Junctional Communication Modulates Gene Expression in Osteoblastic Cells

1998 • 254 citations

Bisphosphonates and Estrogens Inhibit Osteocyte Apoptosis via Distinct Molecular Mechanisms Downstream of Extracellular Signal-regulated Kinase Activation

2004 • 237 citations

DE-cadherin-mediated cell adhesion is essential for maintaining somatic stem cells in the Drosophila ovary

2002 • 226 citations

Inhibition of β-catenin-mediated transactivation by cadherin derivatives

1998 • 217 citations

?-Catenin and BMP-2 synergize to promote osteoblast differentiation and new bone formation

2004 • 212 citations

Disruption of epithelial cell-cell adhesion by exogenous expression of a mutated nonfunctional N-cadherin.

1993 • 199 citations

Expression of M-cadherin, a member of the cadherin multigene family, correlates with differentiation of skeletal muscle cells.

1991 • 191 citations

Formation of heteromeric gap junction channels by connexins 40 and 43 in vascular smooth muscle cells

1999 • 182 citations

Transfected connexin45 alters gap junction permeability in cells expressing endogenous connexin43.

1995 • 174 citations

The role of cadherin in the generation of multinucleated osteoclasts from mononuclear precursors in murine marrow.

1995 • 171 citations

Connexin43 and Connexin45 Form Heteromeric Gap Junction Channels in Which Individual Components Determine Permeability and Regulation

2002 • 170 citations

p27 is involved in N-cadherin-mediated contact inhibition of cell growth and S-phase entry

1999 • 165 citations

Chondrogenic differentiation of murine C3H10T1/2 multipotential mesenchymal cells: II. Stimulation by bone morphogenetic protein-2 requires modulation of N-cadherin expression and function

1999 • 164 citations

The Nonreceptor Protein Tyrosine Phosphatase PTP1B Binds to the Cytoplasmic Domain of N-Cadherin and Regulates the Cadherin–Actin Linkage

1998 • 163 citations

The role of the E-cadherin gene (CDH1) in diffuse gastric cancer susceptibility: from the laboratory to clinical practice

2003 • 161 citations

Gap-junctional communication is required for the maturation process of osteoblastic cells in culture

2001 • 159 citations

Wnt-3A Enhances Bone Morphogenetic Protein-2-mediated Chondrogenesis of Murine C3H10T1/2 Mesenchymal Cells

2002 • 158 citations

Human Osteoblasts Express a Repertoire of Cadherins, Which Are Critical for BMP-2–Induced Osteogenic Differentiation

1998 • 158 citations

Casein Kinase 1: A Wnt'er of Disconnect

2002 • 152 citations

Heart Defects in Connexin43-Deficient Mice

1998 • 148 citations

Diversity in protein–protein interactions of connexins: emerging roles

2004 • 143 citations

The Structure and Function of Cell Adhesion Molecules

1988 • 135 citations

Gap Junctional Communication Modulates Gene Transcription by Altering the Recruitment of Sp1 and Sp3 to Connexin-response Elements in Osteoblast Promoters

2003 • 130 citations

Wnt signaling during BMP‐2 stimulation of mesenchymal chondrogenesis

2002 • 121 citations

Adequate connexin-mediated coupling is required for proper insulin production.

1995 • 121 citations

Adhesive Subdivisions Intrinsic to the Epithelial Somites

1999 • 114 citations

Alterations in the spatiotemporal expression pattern and function of N‐Cadherin inhibit cellular condensation and chondrogenesis of limb mesenchymal cells in vitro

2002 • 113 citations

Gap Junctional Intercellular Communication Contributes to Hormonal Responsiveness in Osteoblastic Networks

1996 • 112 citations

Enhancement of Connexin 43 Expression Increases Proliferation and Differentiation of an Osteoblast-like Cell Line

2001 • 108 citations

Inhibition of Gap-Junctional Communication Induces the Trans-differentiation of Osteoblasts to an Adipocytic Phenotype in Vitro

2001 • 105 citations

A Role for N-Cadherin in the Development of the Differentiated Osteoblastic Phenotype

2000 • 105 citations

Targeted expression of a dominant-negative N-cadherin in vivo delays peak bone mass and increases adipogenesis

2004 • 104 citations

CELLULAR SIGNALING IN DEVELOPMENTAL CHONDROGENESIS

2003 • 104 citations

N-Cadherin-Mediated Human Granulosa Cell Adhesion Prevents Apoptosis

1999 • 103 citations

The Transition of Cadherin Expression in Osteoblast Differentiation from Mesenchymal Cells: Consistent Expression of Cadherin-11 in Osteoblast Lineage

2001 • 101 citations

Inhibiting gap junctional intercellular communication alters expression of differentiation markers in osteoblastic cells

1999 • 99 citations

Relative abundance of different cadherins defines differentiation of mesenchymal precursors into osteogenic, myogenic, or adipogenic pathways

2000 • 99 citations

Regulation of gap junctions by tyrosine protein kinases

2004 • 98 citations

Cx40 and Cx43 expression ratio influences heteromeric/ heterotypic gap junction channel properties

2002 • 97 citations

Connexin 43 suppresses human glioblastoma cell growth by down-regulation of monocyte chemotactic protein 1, as discovered using protein array technology.

2002 • 94 citations

Expression of the Receptor Protein-tyrosine Phosphatase, PTPμ, Restores E-cadherin-dependent Adhesion in Human Prostate Carcinoma Cells

2002 • 93 citations

Expression of M‐cadherin protein in myogenic cells during prenatal mouse development and differentiation of embryonic stem cells in culture

1994 • 92 citations

Targeted Disruption of Cadherin-11 Leads to a Reduction in Bone Density in Calvaria and Long Bone Metaphyses

2001 • 89 citations

Novel Connexin 43 (GJA1) mutation causes oculo–dento–digital dysplasia with curly hair

2004 • 88 citations

Dual Mechanism of Intercellular Communication in HOBIT Osteoblastic Cells: A Role for Gap-Junctional Hemichannels

2001 • 83 citations

N-cadherin is not essential for limb mesenchymal chondrogenesis

2004 • 81 citations

N‐ and E‐cadherin mediate early human calvaria osteoblast differentiation promoted by bone morphogenetic protein‐2

2000 • 79 citations

A Dominant Negative Cadherin Inhibits Osteoblast Differentiation

2000 • 77 citations

Gene expression alterations in connexin null mice extend beyond the gap junction

2004 • 77 citations

Role of N-Cadherin and Protein Kinase C in Osteoblast Gene Activation Induced by the S252W Fibroblast Growth Factor Receptor 2 Mutation in Apert Craniosynostosis

2001 • 77 citations

A new bone to pick: osteoblasts and the haematopoietic stem‐cell niche

2004 • 76 citations

Gap junctions – from cell to molecule

2003 • 75 citations

Cx32 Formation and/or Cx32-Mediated Intercellular Communication Induces Expression and Function of Tight Junctions in Hepatocytic Cell Line

2002 • 74 citations

Roles for ?1 connexin in morphogenesis of chick embryos revealed using a novel antisense approach

1999 • 74 citations

Gap-junctional communication mediates parathyroid hormone stimulation of mineralization in osteoblastic cultures

2001 • 72 citations

N- and E-cadherin mediate early human calvaria osteoblast differentiation promoted by bone morphogenetic protein-2

2000 • 69 citations

Cadherins: an integral role in inflammatory bowel disease and mucosal restitution

2004 • 61 citations

Expression and Function of the Splice Variant of the Human Cadherin-11 Gene in Subordination to Intact Cadherin-11

1999 • 58 citations

Cadherin-6 Mediates the Heterotypic Interactions between the Hemopoietic Osteoclast Cell Lineage and Stromal Cells in a Murine Model of Osteoclast Differentiation

1998 • 58 citations

Genetic heterogeneity in Usher syndrome

2004 • 57 citations

Muscarinic Receptors in Human Luteinized Granulosa Cells: Activation Blocks Gap Junctions and Induces the Transcription Factor Early Growth Response Factor-1

2002 • 44 citations

Connexin43 gap junction protein plays an essential role in morphogenesis of the embryonic chick face

2001 • 35 citations

Retinoic acid inhibits chondrogenesis of mesenchymal cells by sustaining expression of N‐cadherin and its associated proteins

2003 • 34 citations

Altered gene expression in Schwann cells of connexin32 knockout animals

2001 • 28 citations

Knockdown of connexin43‐mediated regulation of the zone of polarizing activity in the developing chick limb leads to digit truncation

2002 • 24 citations

Muscarinic Receptors in Human Luteinized Granulosa Cells: Activation Blocks Gap Junctions and Induces the Transcription Factor Early Growth Response Factor-1

2002 • 15 citations

Deleted Work

1955 • 0 citations