Vitamin D receptor alleles and bone physiology

Prediction of bone density from vitamin D receptor alleles

1994 • 1,931 citations

Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors

1991 • 1,725 citations

Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling

1992 • 1,514 citations

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

1991 • 1,501 citations

Genetic determinants of bone mass in adults. A twin study.

1987 • 1,261 citations

Modulation of Osteoclast Differentiation

1992 • 1,014 citations

Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors

1992 • 966 citations

New biochemical marker for bone metabolism. Measurement by radioimmunoassay of bone GLA protein in the plasma of normal subjects and patients with bone disease.

1980 • 658 citations

Reduced Bone Mass in Daughters of Women with Osteoporosis

1989 • 636 citations

Contribution of trans-acting factor alleles to normal physiological variability: vitamin D receptor gene polymorphism and circulating osteocalcin.

1992 • 604 citations

Protein encoded by v-erbA functions as a thyroid-hormone receptor antagonist

1989 • 599 citations

Retinoic acid receptors and cellular retinoid binding proteins: I. A systematic study of their differential pattern of transcription during mouse organogenesis

1990 • 587 citations

Genetic Factors in Determining Bone Mass

1973 • 586 citations

Prediction of osteoporotic fractures by postural instability and bone density.

1993 • 566 citations

Two nuclear signalling pathways for vitamin D

1993 • 559 citations

1,25-Dihydroxyvitamin D-Responsive Element and Glucocorticoid Repression in the Osteocalcin Gene

1989 • 418 citations

Sequence elements in the human osteocalcin gene confer basal activation and inducible response to hormonal vitamin D3.

1989 • 409 citations

Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3.

1992 • 395 citations

Deficient Production of 1,25-Dihydroxyvitamin D in Elderly Osteoporotic Patients

1981 • 373 citations

Pleiotropic Effects of Vitamin D on Osteoblast Gene Expression Are Related to the Proliferative and Differentiated State of the Bone Cell Phenotype: Dependency upon Basal Levels of Gene Expression, Duration of Exposure, and Bone Matrix Competency in Normal Rat Osteoblast Cultures*

1991 • 352 citations

Genetic determinants of bone mineral content at the spine and radius: A twin study

1987 • 324 citations

DNA sequences in the rat osteocalcin gene that bind the 1,25-dihydroxyvitamin D3 receptor and confer responsiveness to 1,25-dihydroxyvitamin D3.

1990 • 322 citations

Essential role of macrophage colony-stimulating factor in the osteoclast differentiation supported by stromal cells.

1991 • 284 citations

Genetic Factors in Bone Turnover*

1991 • 240 citations

Human vitamin D receptor is selectively phosphorylated by protein kinase C on serine 51, a residue crucial to its trans-activation function.

1991 • 233 citations

Multiple parameters control the selectivity of nuclear receptors for their response elements. Selectivity and promiscuity in response element recognition by retinoic acid receptors and retinoid X receptors.

1993 • 207 citations

Vitamin D receptor interaction with specific DNA requires a nuclear protein and 1,25-dihydroxyvitamin D3.

1990 • 197 citations

1,25-Dihydroxyvitamin D3: short- and long-term effects on bone and calcium metabolism in patients with postmenopausal osteoporosis.

1982 • 188 citations

Interaction between retinoic acid and vitamin D signaling pathways.

1993 • 171 citations

Induction of Calcitonin Receptors by lα, 25- Dihydroxyvitamin D₃in Osteoclast-Like Multinucleated Cells Formed from Mouse Bone Marrow Cells*

1988 • 169 citations

The glucocorticoid receptor binds to a sequence overlapping the TATA box of the human osteocalcin promoter: a potential mechanism for negative regulation.

1991 • 163 citations

Modulation of osteoclast differentiation [published erratum appears in Endocr Rev 1992 May;13(2):191]

1992 • 152 citations

The Vitamin D-Responsive Element in the Rat Bone Gla Protein Gene Is an Imperfect Direct Repeat That Cooperates with Other Cis-Elements in 1,25-Dihydroxyvitamin D₃- Mediated Transcriptional Activation

1991 • 148 citations

Parathyroid Hormone Down-Regulates 1,25-Dihydroxyvitamin D Receptors (VDR) and VDR Messenger Ribonucleic Acidin Vitroand Blocks Homologous Up-Regulation of VDRin Vivo

1990 • 126 citations

Early Postmenopausal Bone Loss is Not Associated with a Decrease in Circulating Levels of 25-Hydroxyvitamin D, 1,25-Dihydroxyvitamin D, or Vitamin D-Binding Protein*

1987 • 107 citations

A Unique Point Mutation in the Human Vitamin D Receptor Chromosomal Gene Confers Hereditary Resistance to 1,25-Dihydroxyvitamin D₃

1990 • 104 citations

1,25-Dihydroxyvitamin D3 up-regulates the 1,25-dihydroxyvitamin D3 receptor in vivo.

1989 • 103 citations

Two hereditary defects related to vitamin D metabolism map to the same region of human chromosome 12q13–14

1992 • 103 citations

A Functional Retinoic Acid Receptor Encoded by the Gene on Human Chromosome 12

1990 • 99 citations

Metacarpal morphometry in monozygotic and dizygotic elderly twins

1978 • 94 citations

A nuclear protein essential for binding of rat 1,25-dihydroxyvitamin D3 receptor to its response elements.

1992 • 94 citations

Role of vitamin D in bone resorption

1992 • 91 citations

Contrasting Effects of Exogenous 1,25-Dihydroxyvitamin D [1,25-(OH)₂D] Versus Endogenous 1,25-(OH)₂D, Induced by Dietary Calcium Restriction, on Vitamin D Receptors

1990 • 87 citations

Evidence that estrogens modulate activity and increase the number of 1,25-dihydroxyvitamin D receptors in osteoblast-like cells (ROS 17/2.8).

1992 • 85 citations

Dexamethasone Increases 1,25-Dihydroxyvitamin D₃Receptor Levels and Augments Bioresponses in Rat Osteoblast-Like Cells*

1986 • 83 citations

Vitamin D-responsive protein-DNA interactions at multiple promoter regulatory elements that contribute to the level of rat osteocalcin gene expression.

1992 • 66 citations

Serum calcium and vitamin D regulate 1,25-dihydroxyvitamin D3 receptor concentration in rat kidney in vivo.

1990 • 65 citations

Ligand-dependent regulation of the 1,25-dihydroxyvitamin D3 receptor in rat osteosarcoma cells.

1987 • 62 citations

Cytokines and local factors which affect osteoclast function

1992 • 50 citations

Estrogen, cytokines, and the control of osteoclast formation and bone resorption in vitro and in vivo

1993 • 47 citations

Vitamin D-influenced gene expression via a ligand-independent, receptor-DNA complex intermediate.

1993 • 38 citations

Sites of phosphorylation and photoaffinity labeling of the 1,25-dihydroxyvitamin D3 receptor

1991 • 35 citations

Transforming growth factor-beta modulates receptor binding of calciotropic hormones and G protein-mediated adenylate cyclase responses in osteoblast-like cells.

1992 • 35 citations

Constitutive expression of osteoclast-stimulating activity by normal clonal osteoblast-like cells: effects of parathyroid hormone and 1,25-dihydroxyvitamin D3.

1992 • 26 citations

Retinoic Acid-Induced Changes in 1α,25-Dihydroxyvitamin D<sub>3</sub> Receptor Levels in Tumor and Nontumor Cells Derived From Rat Bone<xref ref-type="fn" rid="FN2">2</xref>

1987 • 18 citations

Transforming growth factor-beta modulates receptor binding of calciotropic hormones and G protein-mediated adenylate cyclase responses in osteoblast-like cells

1992 • 11 citations

Constitutive expression of osteoclast-stimulating activity by normal clonal osteoblast-like cells: effects of parathyroid hormone and 1,25- dihydroxyvitamin D3

1992 • 11 citations