High Serum Levels of Soluble IL-2 Receptor, Cytokines, and C Reactive Protein Correlate with Impairment of T Cell Response in Patients with Advanced Epithelial Ovarian Cancer

A Progress Report on the Treatment of 157 Patients with Advanced Cancer Using Lymphokine-Activated Killer Cells and Interleukin-2 or High-Dose Interleukin-2 Alone

1987 • 2,769 citations

Interleukin-1 and the Pathogenesis of the Acute-Phase Response

1984 • 1,136 citations

Acute-phase response of human hepatocytes: Regulation of acute-phase protein synthesis by interleukin-6

1990 • 742 citations

Evidence for the involvement of interleukin 6 in experimental cancer cachexia.

1992 • 648 citations

Progress in immunology

1968 • 577 citations

The interleukin-2 receptor.

1991 • 354 citations

Constitutive production of interleukin 6 by ovarian cancer cell lines and by primary ovarian tumor cultures.

1990 • 226 citations

Serum interleukin-6 levels correlate with disease status in patients with epithelial ovarian cancer

1991 • 214 citations

Anticachectin/tumor necrosis factor‐α antibodies attenuate development of cachexia in tumor models

1989 • 210 citations

Prognostic significance of interleukin 6 serum levels in patients with ovarian cancer

1995 • 195 citations

Interleukin-6 level in serum and ascites as a prognostic factor in patients with epithelial ovarian cancer

1994 • 172 citations

Correlation of T and B cell activities in vitro and serum IL-2 levels in systemic lupus erythematosus.

1988 • 162 citations

IL-6 produced by macrophages infected with Mycobacterium species suppresses T cell responses.

1997 • 158 citations

Serum and ascitic fluid levels of interleukin-1, interleukin-6, and tumor necrosis factor-alpha in patients with ovarian epithelial cancer

1993 • 145 citations

Serum interleukin 6 and C-reactive protein levels correlate with resistance to IL-2 therapy and poor survival in melanoma patients

1994 • 121 citations

Medroxyprogesterone acetate reduces the in vitro production of cytokines and serotonin involved in anorexia/cachexia and emesis by peripheral blood mononuclear cells of cancer patients

1997 • 118 citations

The role of tumor necrosis factor (cachectin) in cachexia

1988 • 117 citations

Soluble interleukin-2 receptors in the sera of patients with hairy cell leukemia: relationship with the effect of recombinant alpha-interferon therapy on clinical parameters and natural killer in vitro activity

1987 • 111 citations

Stimulation of ovarian tumor cell proliferation with monocyte products including interleukin-1, interleukin-6, and tumor necrosis factor-α

1992 • 102 citations

Cytokines and Their Role in the Pathophysiology of Cancer Cachexia

1992 • 95 citations

Comparison of serum amyloid A protein and C-reactive protein concentrations in cancer and non-malignant disease.

1983 • 83 citations

Multivariate analyses as aids to diagnosis and assessment of prognosis in gastrointestinal cancer

1983 • 79 citations

Megestrol acetate in neoplastic anorexia/cachexia: clinical evaluation and comparison with cytokine levels in patients with head and neck carcinoma treated with neoadjuvant chemotherapy

1995 • 77 citations

High serum and ascitic soluble interleukin-2 receptor alpha levels in advanced epithelial ovarian cancer [see comments]

1993 • 51 citations

Complement activation in cancer patients undergoing immunotherapy with interleukin-2 (IL-2): binding of complement and C-reactive protein by IL-2-activated lymphocytes

1991 • 43 citations

Tumor-associated lympho-monocytes from neoplastic effusions are immunologically defective in comparison with patient autologous PBMCs but are capable of releasing high amounts of various cytokines

1997 • 43 citations

Serum levels of the low-affinity interleukin-2 receptor molecule (TAC) during IL-2 therapy reflect systemic lymphoid mass activation

1989 • 43 citations

High serum and ascitic soluble interleukin-2 receptor alpha levels in advanced epithelial ovarian cancer [see comments]

1993 • 36 citations

Interleukin-2 and the Interleukin-2 Receptor Complex

2015 • 34 citations

Serum interleukin-6 levels during bone marrow transplantation: impact on transplant-related toxicity and engraftment.

1996 • 27 citations

In vivo cytokine production and recombinant interleukin 2 immunotherapy: an insight into the possible mechanisms underlying clinical responses

1994 • 26 citations

Reversal of suppression of lymphokine-activated killer cells by transforming growth factor-β in ovarian carcinoma ascitic fluid requires interleukin-2 combined with anti-CD3 antibody

1992 • 26 citations

Interleukin 2 therapy in cancer: identification of responders

1992 • 21 citations

LACK OF CORRELATION BETWEEN DEFECTIVE CELL-MEDIATED-IMMUNITY AND LEVELS OF SECRETED OR CIRCULATING CYTOKINES IN A STUDY OF 90 CANCER-PATIENTS

1994 • 13 citations

Anti-C-reactive protein inhibits the calcium-dependent stage of natural killer cell activation.

1991 • 12 citations

Peripheral Blood Lymphocyte Response to Exogenous Interleukin 2 by PHA-Prestimulated and Non-PHA-Prestimulated Cells in Patients with Cancer

1986 • 10 citations

IL-1 synergy with IL-2 in the generation of lymphokine activated killer cells is mediated by TNF-α and β (lymphotoxin)

1992 • 8 citations

The Cytokine Network: Their Role in Physiopathology and Therapeutic Implications

1992 • 7 citations

Immunological Control of Tumor Metastases

1989 • 7 citations