IL-1 synergy with IL-2 in the generation of lymphokine activated killer cells is mediated by TNF-α and β (lymphotoxin)

Lymphokine-activated killer cell phenomenon. Lysis of natural killer-resistant fresh solid tumor cells by interleukin 2-activated autologous human peripheral blood lymphocytes.

1982 • 2,228 citations

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

1986 • 1,501 citations

Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.

1985 • 922 citations

Tumor necrosis factor/cachectin interacts with endothelial cell receptors to induce release of interleukin 1.

1986 • 709 citations

Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies.

1990 • 678 citations

Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-alpha: induction of TNF receptors on human T cells and TNF-alpha-mediated enhancement of T cell responses.

1987 • 490 citations

Characterization of binding and biological effects of monoclonal antibodies against a human tumor necrosis factor receptor.

1990 • 263 citations

Generation of activated killer (AK) cells by recombinant interleukin 2 (rIL 2) in collaboration with interferon-gamma (IFN-gamma).

1985 • 184 citations

Synergy of tumor necrosis factor and interleukin 2 in the activation of human cytotoxic lymphocytes: effect of tumor necrosis factor alpha and interleukin 2 in the generation of human lymphokine-activated killer cell cytotoxicity.

1988 • 172 citations

Interleukin-2 in cancer therapy.

1988 • 115 citations

Involvement of the 55- and 75-kDa tumor necrosis factor receptors in the generation of lymphokine-activated killer cell activity and proliferation of natural killer cells.

1991 • 105 citations

Tumor necrosis factors alpha and beta differ in their capacities to generate interleukin 1 release from human endothelial cells.

1987 • 99 citations

Characterization of human tumor necrosis factor produced by peripheral blood monocytes and its separation from lymphotoxin

1985 • 92 citations

Synergy of human recombinant interleukin 1 with interleukin 2 in the generation of lymphokine-activated killer cells.

1989 • 74 citations

Regulation of lymphocyte tumor necrosis factor receptors by IL-2.

1989 • 59 citations

TGF-Beta inhibits the in vitro induction of lymphokine-activated killing activity

1988 • 58 citations

Evidence for tumor necrosis factor-alpha involvement in the optimal induction of class I allospecific cytotoxic T cells.

1990 • 55 citations

RNA processing is a limiting step for murine tumor necrosis factor beta expression in response to interleukin-2.

1990 • 52 citations

Characterization of the receptor for tumor necrosis factor (TNF) and lymphotoxin (LT) on human T lymphocytes. TNF and LT differ in their receptor binding properties and the induction of MHC class I proteins on a human CD4+ T cell hybridoma.

1990 • 44 citations

Cytokine Regulation of Tumor Necrosis Factor-α and -β (Lymphotoxin)-Messenger RNA Expression in Human Peripheral Blood Mononuclear Cells

1990 • 29 citations

Enhancement of lymphokine-activated T killer cell tumor necrosis factor receptor mRNA transcription, tumor necrosis factor receptor membrane expression, and tumor necrosis factor/lymphotoxin release by IL-1 beta, IL-4, and IL-6 in vitro.

1991 • 22 citations

Lymphokine‐Activated Killer Cells

1988 • 16 citations

Cytokine regulation of tumor necrosis factor-alpha and -beta (lymphotoxin)-messenger RNA expression in human peripheral blood mononuclear cells.

1990 • 7 citations

TNF-beta (lymphotoxin) strongly upregulates TNF-alpha gene expression in human peripheral blood lymphocytes.

1990 • 6 citations

Cytotoxic T cells: Biology and relevance to disease

1987 • 4 citations

Lymphocytes in immunotherapy of cancer

1990 • 1 citations