Effects of Topiramate on Sodium‐Dependent Action‐Potential Firing by Mouse Spinal Cord Neurons in Cell Culture

An Overview of the Preclinical Aspects of Topiramate: Pharmacology, Pharmacokinetics, and Mechanism of Action

2000 • 802 citations

Antiepileptic drugs: pharmacological mechanisms and clinical efficacy with consideration of promising developmental stage compounds.

1990 • 647 citations

Topiramate: Preclinical Evaluation of a Structurally Novel Anticonvulsant

1994 • 348 citations

An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels

1992 • 281 citations

Carbamazepine and 10,11-epoxycarbamazepine produce use- and voltage-dependent limitation of rapidly firing action potentials of mouse central neurons in cell culture.

1986 • 237 citations

Frequency and voltage-dependent inhibition of type IIA Na+ channels, expressed in a mammalian cell line, by local anesthetic, antiarrhythmic, and anticonvulsant drugs.

1991 • 222 citations

Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells

1997 • 220 citations

Multiple actions of phenytoin on mouse spinal cord neurons in cell culture.

1983 • 202 citations

Lamotrigine, phenytoin and carbamazepine interactions on the sodium current present in N4TG1 mouse neuroblastoma cells.

1993 • 179 citations

Effects of Topiramate on Sustained Repetitive Firing and Spontaneous Recurrent Seizure Discharges in Cultured Hippocampal Neurons

2000 • 150 citations

Phenytoin and Carbamazepine: Potential‐ and Frequency‐Dependent Block of Na Currents in Mammalian Myelinated Nerve Fibers

1989 • 137 citations

Limitation by gabapentin of high frequency action potential firing by mouse central neurons in cell culture

1994 • 86 citations

Modulated anticonvulsant block of sodium channels in nerve and muscle

1983 • 85 citations

Selective effects of TPM on sustained repetitive firing and spontaneous bursting in cultured hippocampal neurons

1993 • 68 citations

Effects of Topiramate on Sustained Repetitive Firing and Spontaneous Recurrent Seizure Discharges in Cultured Hippocampal Neurons

2000 • 58 citations