Functional and metabolic perturbations in isolated pancreatic islets from the GK rat, a genetic model of noninsulin-dependent diabetes.

Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas

1967 • 2,783 citations

β-Cell Dysfunction Induced by Chronic Hyperglycemia: Current Ideas on Mechanism of Impaired Glucose-Induced Insulin Secretion

1992 • 356 citations

Insulin release: The fuel hypothesis

1979 • 351 citations

Spontaneous Diabetes Produced by Selective Breeding of Normal Wistar Rats

1975 • 269 citations

β-Cell Insensitivity to Glucose in the GK Rat, a Spontaneous Nonobese Model for Type II Diabetes

1991 • 259 citations

Elusive Proximal Signals of β-Cells for Insulin Secretion

1990 • 151 citations

Calcium-antagonists and islet function

1976 • 128 citations

Hexose metabolism in pancreatic islets. Feedback control of d-glucose oxidation by functional events

1988 • 105 citations

Failure of glucose to elicit a normal secretory response in fetal pancreatic beta cells results from glucose insensitivity of the ATP-regulated K+ channels.

1989 • 105 citations

Stimulation by <scp>d</scp>-glucose of mitochondrial oxidative events in islet cells

1987 • 101 citations

Impaired insulin secretion in the spontaneous diabetes rats.

1982 • 90 citations

Cytochalasin B-Induced Impairment of Glucose Metabolism in Islets of Langerhans

1976 • 86 citations

Long-term exposure of isolated pancreatic islets to mannoheptulose: Evidence for insulin degradation in the β cell

1980 • 83 citations

The stimulus-secretion coupling of glucose-induced insulin release

1976 • 70 citations

Insulin release : the fuel concept.

1983 • 64 citations

Effect of esters of succinic acid and other citric acid cycle intermediates on insulin release and inositol phosphate formation by pancreatic islets

1989 • 62 citations

Glucose-sensing by the pancreatic B-cell: The mitochondrial part

1992 • 53 citations

Insulin Production and Glucose Metabolism in Isolated Pancreatic Islets of Rats With NIDDM

1988 • 50 citations

Standardization of Insulin Secretion from Pancreatic Islets: Validation of a DNA Assay

1985 • 42 citations

Elevated Proinsulin Biosynthesis In Vitro from a Rat Model of Non-insulin-dependent Diabetes Mellitus

1983 • 27 citations

The Role of Ca²⁺-Related Events in Glucose-Stimulated Desensitization of Insulin Secretion*

1991 • 19 citations

Preferential stimulation by glucose of its oxidation relative to glycolysis in purified insulin-producing cells.

1991 • 14 citations

Impact of uncoupling glucose stimulus from secretion on B-cell release and biosynthesis

1992 • 9 citations