Protein binding of drugs in plasma, interstitial fluid and tissues: Effect on pharmacokinetics

A physiological approach to hepatic drug clearance

1975 • 1,855 citations

Biopharmaceutics and Relevant Pharmacokinetics

1970 • 617 citations

Plasma and Tissue Protein Binding of Drugs in Pharmacokinetics

1976 • 375 citations

FACTORS AFFECTING DRUG METABOLISM

1971 • 342 citations

Effect of Altered Plasma Protein Binding on Apparent Volume of Distribution

1979 • 247 citations

Pharmacokinetics of drugs in patients with the nephrotic syndrome.

1975 • 137 citations

Diseases and Drug Protein Binding

1978 • 132 citations

Apparent volumes of distribution and drug binding to plasma proteins and tissues

1978 • 102 citations

Comparative Pharmacokinetics of Coumarin Anticoagulants XIV: Relationship between Protein Binding, Distribution, and Elimination Kinetics of Warfarin in Rats

1975 • 101 citations

Albumin metabolism in the nephrotic syndrome in adults.

1967 • 96 citations

Effect of plasma protein and tissue binding on the biologic half‐life of drugs

1978 • 75 citations

Effects of hormonal contraceptives and pregnancy on serum protein pattern

1973 • 35 citations

Comparative Pharmacokinetics of Coumarin Anticoagulants XXXII: Interindividual Differences in Binding of Warfarin and Dicumarol in Rat Liver and Implications for Physiological Pharmacokinetic Modeling

1978 • 28 citations

Effect of Serum Protein Binding on Sulfisoxazole Distribution, Metabolism, and Excretion in Rats

1979 • 25 citations

Comparative Pharmacokinetics of Coumarin Anticoagulants XXXI: Effect of Plasma Protein Binding on Distribution Kinetics of Dicumarol in Rats

1977 • 22 citations

THE DISTRIBUTION OF PROTEINS BETWEEN INTRAAND EXTRAVASCULAR SPACES IN HEALTH AND DISEASE

1971 • 14 citations