The relationship between elevated interstitial fluid pressure and blood flow in tumors: a bioengineering analysis

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1989 • 3,308 citations

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

1955 • 2,174 citations

Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix.

1996 • 1,747 citations

Determinants of tumor blood flow: a review.

1988 • 1,362 citations

Transport of molecules in the tumor interstitium: a review.

1987 • 1,360 citations

Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma.

1996 • 1,183 citations

Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection

1989 • 836 citations

Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy

1988 • 811 citations

Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix

1993 • 811 citations

Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy.

1990 • 742 citations

Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure.

1988 • 703 citations

Oxygenation predicts radiation response and survival in patients with cervix cancer

1998 • 604 citations

Evidence for acutely hypoxic cells in mouse tumours, and a possible mechanism of reoxygenation

1979 • 523 citations

Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions.

1991 • 505 citations

Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse.

1992 • 501 citations

Respiration and Circulation.

1971 • 461 citations

Definitive evidence for hypoxic cells influencing cure in cancer therapy.

1978 • 422 citations

Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma.

1996 • 365 citations

Analysis of the Effects of Oxygen Supply and Demand on Hypoxic Fraction in Tumors

1995 • 268 citations

Time-dependent behavior of interstitial fluid pressure in solid tumors: implications for drug delivery.

1995 • 263 citations

Interstitial hypertension in human breast and colorectal tumors.

1992 • 251 citations

Interstitial hypertension in head and neck tumors in patients: correlation with tumor size.

1992 • 246 citations

Interstitial hypertension in superficial metastatic melanomas in humans.

1991 • 217 citations

Effect of Transvascular Fluid Exchange on Pressure–Flow Relationship in Tumors: A Proposed Mechanism for Tumor Blood Flow Heterogeneity

1996 • 179 citations

Interstitial hypertension in carcinoma of uterine cervix in patients: possible correlation with tumor oxygenation and radiation response.

1991 • 178 citations

Geometric resistance to blood flow in solid tumors perfused ex vivo: effects of tumor size and perfusion pressure.

1989 • 173 citations

Interstitial pressure of subcutaneous nodules in melanoma and lymphoma patients: changes during treatment.

1993 • 164 citations

Concepts of oxygen transport at the microcirculatory level

1998 • 160 citations

Transmural Coupling of Fluid Flow in Microcirculatory Network and Interstitium in Tumors

1997 • 144 citations

Viscous resistance to blood flow in solid tumors: effect of hematocrit on intratumor blood viscosity.

1989 • 137 citations

Characteristics of chromate workers' cancers, chromium lung deposition and precancerous bronchial lesions: an autopsy study

1994 • 118 citations

Temporal heterogeneity in microregional erythrocyte flux in experimental solid tumours

1995 • 108 citations

Nicotinamide can lower tumor interstitial fluid pressure: mechanistic and therapeutic implications.

1992 • 106 citations

Interstitial fluid pressure in cervical carcinoma

1998 • 99 citations

A comparison of tumor and normal tissue microvascular hematocrits and red cell fluxes in a rat window chamber model

1993 • 89 citations

Microregional fluctuations in perfusion within human tumours detected using laser Doppler flowmetry

1996 • 89 citations

Measurement of capillary filtration coefficient in a solid tumor.

1991 • 80 citations

Dexamethasone reduces the interstitial fluid pressure in a human colon adenocarcinoma xenograft.

1993 • 75 citations

Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline

1994 • 73 citations

Microvascular networks: experimental and theoretical studies

1987 • 61 citations

Viscoelastic Properties of Microvessels in Rat Spinotrapezius Muscle

1986 • 49 citations

The effects of leukocytes on blood flow in a model skeletal muscle capillary network

1990 • 44 citations

Tumor perfusion in relation to the rapid growth phase and necrosis: Studies on the walker carcinoma in the rat testicle

1982 • 37 citations

The relationship between mouse arterial partial pressure of oxygen (PaO₂) and the effectiveness of localized tumour irradiation

1975 • 37 citations

Subatmospheric closing pressures in individual microvessels of rats and frogs.

1995 • 28 citations

The vascular pattern of the spontaneous C3H mouse mammary carcinoma and its significance in radiation response and in hyperthermia

1980 • 28 citations

Microvascular pressures in DMBA-induced rat mammary tumours

1982 • 24 citations

Microvascular pressures in DMBA-induced rat mammary tumours

1982 • 20 citations

A Theory of Blood Flow in Skeletal Muscle

1988 • 19 citations

Nicotinamide reduces tumour interstitial fluid pressure in a dose- and time-dependent manner.

1997 • 16 citations

Theoretical and Experimental Analysis of Hematocrit Distribution in Microcirculatory Networks

1989 • 16 citations

Microvascular Mechanics

1989 • 14 citations

Bioengineering Analysis of Blood Flow in Resting Skeletal Muscle

1989 • 12 citations

Network Hemodynamics and the Shear Rate Dependency of Blood Viscosity1

2015 • 11 citations

Mathematical Simulation of Blood Flow in Microcirculatory Networks

2015 • 11 citations