Comparative metabonomics of differential hydrazine toxicity in the rat and mouse

'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data

1999 • 3,649 citations

Metabonomics: a platform for studying drug toxicity and gene function

2002 • 1,871 citations

Basic Neurochemistry???Molecular, Cellular, and Medical Aspects

2006 • 1,374 citations

Basic Neurochemistry: Molecular, Cellular, and Medical Aspects

1989 • 1,360 citations

750 MHz 1H and 1H-13C NMR Spectroscopy of Human Blood Plasma

1995 • 1,004 citations

Chemometrics: A Practical Guide

1999 • 944 citations

Chemometrics: A Practical Guide

1999 • 893 citations

Metabolite profiling by one- and two-dimensional NMR analysis of complex mixtures

1996 • 705 citations

High resolution proton magnetic resonance spectroscopy of biological fluids

1989 • 615 citations

An NMR‐based metabonomic approach to investigate the biochemical consequences of genetic strain differences: application to the C57BL10J and Alpk:ApfCD mouse

2000 • 319 citations

Chemometric Models for Toxicity Classification Based on NMR Spectra of Biofluids

2000 • 277 citations

Nuclear Magnetic Resonance Spectroscopic and Principal Components Analysis Investigations into Biochemical Effects of Three Model Hepatotoxins

1998 • 267 citations

Metabonomics: Evaluation of Nuclear Magnetic Resonance (NMR) and Pattern Recognition Technology for Rapid in Vivo Screening of Liver and Kidney Toxicants

2000 • 257 citations

High resolution 1H n.m.r. studies of vertebrate blood and plasma

1983 • 250 citations

Development of a model for classification of toxin-induced lesions using1H NMR spectroscopy of urine combined with pattern recognition

1998 • 227 citations

Investigations into the biochemical effects of region-specific nephrotoxins.

1989 • 206 citations

Metabonomic Investigations into Hydrazine Toxicity in the Rat

2001 • 183 citations

Physiological variation in metabolic phenotyping and functional genomic studies: use of orthogonal signal correction and PLS‐DA

2002 • 179 citations

Nuclear magnetic resonance spectroscopy and pattern recognition analysis of the biochemical processes associated with the progression of and recovery from nephrotoxic lesions in the rat induced by mercury(II) chloride and 2-bromoethanamine.

1992 • 167 citations

The identification of novel biomarkers of renal toxicity using automatic data reduction techniques and PCA of proton NMR spectra of urine

1998 • 164 citations

Application of pattern recognition methods to the analysis and classification of toxicological data derived from proton nuclear magnetic resonance spectroscopy of urine.

1991 • 160 citations

Proton NMR spectra of urine as indicators of renal damage. Mercury-induced nephrotoxicity in rats.

1985 • 156 citations

Pattern recognition classification of the site of nephrotoxicity based on metabolic data derived from proton nuclear magnetic resonance spectra of urine.

1994 • 141 citations

Geometric Trajectory Analysis of Metabolic Responses To Toxicity Can Define Treatment Specific Profiles

2004 • 133 citations

A Genetic polymorphism of the N-oxidation of trimethylamine in humans

1987 • 111 citations

Arylamine N-acetyltransferases – of mice, men and microorganisms

2001 • 110 citations

Studies on the pathophysiology of acute renal failure

1976 • 109 citations

Investigations into the effects of various hepatotoxic compounds on urinary and liver taurine levels in rats

1993 • 105 citations

NMR spectroscopy based metabonomic studies on the comparative biochemistry of the kidney and urine of the bank vole (Clethrionomys glareolus), wood mouse (Apodemus sylvaticus), white toothed shrew (Crocidura suaveolens) and the laboratory rat

2000 • 98 citations

Plasma Hydrazine Concentrations in Man after Isoniazid and Hydralazine Administration

1985 • 97 citations

Earthworm species of the genus Eisenia can be phenotypically differentiated by metabolic profiling

2002 • 93 citations

Quantitative high resolution 1H NMR urinalysis studies on the biochemical effects of cadmium in the rat.

1989 • 86 citations

Purines and Neuroprotection

2003 • 78 citations

Pretreatment of human colon tumor cells with DNA methylating agents inhibits their ability to repair chloroethyl monoadducts

1984 • 75 citations

Stereospecificity of the gliotoxic and anti-neurotoxic actions of alpha-aminoadipate

1980 • 74 citations

Pharmacokinetics of the toxic hydrazino metabolites formed from isoniazid in humans.

1985 • 73 citations

Hepatotoxin-induced hypertaurinuria: a proton NMR study

1990 • 61 citations

Two-Year Toxicity and Carcinogenicity Study of Methyleugenol in F344/N Rats and B6C3F₁Mice

2000 • 60 citations

ANIMAL MODELS OF HUMAN DISEASE IN DRUG SAFETY ASSESSMENT

2003 • 60 citations

Reduction of liver taurine in rats by β-alanine treatment increases carbon tetrachloride toxicity

1993 • 55 citations

The Concept of Multispecies Testing in Industrial Toxicology

1993 • 50 citations

Proton NMR spectroscopic studies on the metabolism and biochemical effects of hydrazine in vivo

1992 • 44 citations

Comparative studies on the nephrotoxicity of 2-bromoethanamine hydrobromide in the Fischer 344 rat and the multimammate desert mouse (Mastomys natalensis)

1995 • 43 citations

The question of carcinogenic effects of hydrazine

1988 • 41 citations

Hydrazine-induced alterations in rat liver. A correlation of the chemical and histologic changes in acute hydrazine intoxication.

1962 • 40 citations

Elevation of Brain GABA Content by Chronic Low‐Dosage Administration of Hydrazine, a Metabolite of Isoniazid

1981 • 38 citations

THE ROLE OF VITAMIN B₆ IN THE TOXICITY OF HYDRAZINES*

1969 • 38 citations

Species differences in the N-acetylation by liver cytosol of mutagenic heterocyclic aromatic amines in protein pyrolysates

1984 • 35 citations

Identification of novel hydrazine metabolites by 15N-NMR

1991 • 33 citations

Effect of various non-hepatotoxic compounds on urinary and liver taurine levels in rats

1993 • 33 citations

Course of ATP depletion in hydrazine hepatotoxicity

1990 • 31 citations

Factors affecting the metabolism of [14C]acetylhydrazine in rats.

1978 • 30 citations

Starvation-induced posttranscriptional control of rat liver mitochondrial citrate carrier expression

2002 • 25 citations

Slow-Binding Inhibition of γ-Aminobutyric Acid Aminotransferase by Hydrazine Analogues^,

1996 • 25 citations

Metabolic fate of hydrazine

1981 • 23 citations

Assessing the Potential Toxicity of New Pharmaceuticals

2001 • 20 citations

Studies on the pathophysiology of acute renal failure

1980 • 19 citations

Comparative biochemical effects of low doses of mercury II chloride in the F344 rat and the multimammate mouse (Mastomys natalensis)

1996 • 17 citations

Walking through the forest of transgenic models of human disease

1999 • 15 citations

Arylamine N-acetyltransferase from fast (C57BL6) and slow (A/J) N-Acetylating strains of mice

1990 • 14 citations

Comparisons of urinary creatinine, skeletal muscle mass, and indices of muscle protein catabolism in rats fed ad libitum, with restricted food intake, and deprived of food.

1989 • 13 citations

Effect of hydrazine on urea cycle enzymes in vitro and in vivo

1971 • 13 citations

Proton NMR studies on the effects of uranyl nitrate on the biochemical composition of rat urine and plasma

1990 • 13 citations

Long-term effect of partial nephrectomy on biological parameters, kidney histology, and guanidino compound levels in mice

2001 • 10 citations

Application of toxicogenomics to drug development

2002 • 10 citations

[Biosynthesis of guanidinoacetic acid in isolated rat tubules].

1990 • 2 citations

Nuclear magnetic resonance spectroscopic and chemometric studies on experimental CNS pathology.

2003 • 1 citations