BrainN-acetyl-l-aspartic acid in Alzheimer's disease: a proton magnetic resonance spectroscopy study

“Mini-mental state”

1975 • 82,784 citations

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

The Association Between Quantitative Measures of Dementia and of Senile Change in the Cerebral Grey Matter of Elderly Subjects

1968 • 4,041 citations

Diagnosis of Alzheimer's Disease

1985 • 2,482 citations

Alzheimer's Disease: Cell-Specific Pathology Isolates the Hippocampal Formation

1984 • 2,199 citations

Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer disease.

1985 • 979 citations

Some morphometric aspects of the brain in senile dementia of the alzheimer type

1981 • 803 citations

N-Acetyl-L-Aspartic acid: A literature review of a compound prominent in 1H-NMR spectroscopic studies of brain

1989 • 775 citations

Perforant pathway changes and the memory impairment of Alzheimer's disease

1986 • 665 citations

Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia

1977 • 628 citations

A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease

1987 • 602 citations

Localized proton NMR spectroscopy in different regions of the human brain in vivo. Relaxation times and concentrations of cerebral metabolites

1989 • 515 citations

Specific Expression of N‐Acetylaspartate in Neurons, Oligodendrocyte‐Type‐2 Astrocyte Progenitors, and Immature Oligodendrocytes In Vitro

1992 • 504 citations

Quantification of magnetic resonance scans for hippocampal and parahippocampal atrophy in Alzheimer's disease

1991 • 421 citations

Alzheimer disease: depiction of increased cerebral myo-inositol with proton MR spectroscopy.

1993 • 354 citations

N‐Acetyl‐Aspartyl‐Glutamate: Regional Levels in Rat Brain and the Effects of Brain Lesions as Determined by a New HPLC Method

1984 • 344 citations

Quantitative NMR measurements of hippocampal atrophy in Alzheimer's disease

1988 • 340 citations

Cerebral metabolism in man after acute stroke: New observations using localized proton NMR spectroscopy

1989 • 326 citations

ACCELERATED AGEING OR SELECTIVE NEURONAL LOSS AS AN IMPORTANT CAUSE OF DEMENTIA?

1979 • 326 citations

N-ACETYL-l-ASPARTIC ACID IN BRAIN

1956 • 325 citations

Cortical neuronal counts in normal elderly controls and demented patients

1983 • 293 citations

Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease.

1991 • 292 citations

Amygdaloid Changes in Aging and Dementia

1980 • 257 citations

AN ANALYSIS OF FACTORS INFLUENCING MEASUREMENTS OF DOPAMINE, NORADRENALINE, GLUTAMATEDECARBOXYLASE AND CHOLINE ACETYLASE IN HUMAN POST-MORTEM BRAIN TISSUE

1979 • 219 citations

N‐ACETYL‐<scp>l</scp>‐ASPARTIC ACID CONTENT OF HUMAN NEURAL TUMOURS AND BOVINE PERIPHERAL NERVOUS TISSUES

1972 • 213 citations

High‐field proton magnetic resonance spectroscopy of human cerebrum obtained during surgery for epilepsy

1989 • 206 citations

High‐Resolution Proton Magnetic Resonance Spectroscopy of Rabbit Brain: Regional Metabolite Levels and Postmortem Changes

1988 • 188 citations

A Gas Chromatographic Method for the Determination of N‐Acetyl‐<scp>l</scp>‐Aspartic Acid, N‐Acetyl‐α‐ Aspartylglutamic Acid and β‐Citryl‐<scp>l</scp>‐Glutamic Acid and Their Distributions in the Brain and Other Organs of Various Species of Animals

1981 • 181 citations

N ‐acetyl‐L‐aspartate and other amino acid metabolites in Alzheimer's disease brain

1992 • 175 citations

FREE AMINO ACIDS AND RELATED COMPOUNDS IN DOG BRAIN: POST‐MORTEM AND ANOXIC CHANGES, EFFECTS OF AMMONIUM CHLORIDE INFUSION, AND LEVELS DURING SEIZURES INDUCED BY PICROTOXIN AND BY PENTYLENETETRAZOL*

1963 • 168 citations

COMPARATIVE NEUROCHEMISTRY

1965 • 166 citations

THE PROGRESSION OF THE PATHOLOGICAL CHANGES OF ALZHEIMER'S DISEASE IN FRONTAL AND TEMPORAL NEOCORTEX EXAMINED BOTH AT BIOPSY AND AT AUTOPSY

1988 • 159 citations

Effect of Hypoglycemic Encephalopathy upon Amino Acids, High‐Energy Phosphates, and pH_i in the Rat Brain In Vivo: Detection by Sequential ¹H and ³¹P NMR Spectroscopy

1985 • 156 citations

Topographical distribution of neurochemical changes in Alzheimer's disease

1988 • 137 citations

Correlation between senile plaque and neurofibrillary tangle counts in cerebral cortex and neuronal counts in cortex and subcortical structures in Alzheimer's disease

1985 • 127 citations

Excitatory amino acid-releasing and cholinergic neurones in Alzheimer's disease

1986 • 118 citations

Proton MR Spectroscopy of the Brain in AIDS Dementia Complex

1992 • 100 citations

Studies on the Role of N-Acetylaspartic Acid in Mammalian Brain

1959 • 94 citations

STUDIES ON FREE AMINO ACIDS IN HUMAN BRAIN

1960 • 92 citations

A quantitative study of the neurofibrillary tangles and the choline acetyltransferase activity in the cerebral cortex and the amygdala in Alzheimer's disease.

1990 • 90 citations

SUBCELLULAR LOCALIZATION OF N‐ACETYL‐ASPARTYL‐GLUTAMATE, N‐ACETYL‐GLUTAMATE AND GLUTATHIONE IN BRAIN

1969 • 88 citations

STUDIES ON THE FUNCTION OF N‐ACETYL ASPARTIC ACID IN BRAIN

1965 • 87 citations

Brain development:1H magnetic resonance spectroscopy of rat brain extracts compared with chromatographic methods

1990 • 79 citations

Serial Proton Magnetic Resonance Spectroscopy of Ischemic Brain Injury in Humans

1990 • 78 citations

Proton MR Spectroscopy in Herpes Simplex Encephalitis

1990 • 64 citations

Comparison of lactate concentration determinations in ischemic and hypoxic rat brains by in vivo and in vitro¹H NMR spectroscopy

1987 • 60 citations

Pre-operative localized in vivo proton spectroscopy in cerebral tumors at 4.0 Tesla—First results

1989 • 59 citations

THE MEASUREMENT OF FREE AND N‐ACETYLATED ASPARTIC ACIDS IN THE NERVOUS SYSTEM*

1966 • 55 citations

Proton nuclear magnetic resonance spectra of excised rat brain. Assignment of resonances.

1985 • 53 citations

EFFECT OF DRUGS ON AMINO ACID LEVELS IN THE RAT BRAIN: HYPOGLYCEMIC AGENTS

1961 • 51 citations

Acetyl transport mechanisms Metabolism of acid in the non-nervous tissues of the rat

1968 • 49 citations

Concentrations of several proteins characteristic of nervous tissue in cerebral cortex of patients with alzheimer’s disease

1991 • 40 citations

The Influences of Insulin Hypoglycaemic Coma, Repeated Electroshocks, and Chlorpromazine or β-Phenylisopropylmethylamine Administration on the Free Amino Acids in the Brain

1959 • 35 citations

Function of N-Acetyl Aspartic Acid in the Brain : Effects of Certain Drugs

1964 • 25 citations

DISTRIBUTION OF AMINO ACIDS IN THE BRAIN IN DIFFERENT SPECIES

1964 • 22 citations

POSTNATAL CHANGES IN BRAIN N‐ACETYL‐<scp>l</scp>‐ASPARTIC ACID CONTENT OF NORMAL AND HYPOTHYROID SUCKLING RATS

1967 • 22 citations

Proton nuclear magnetic resonance spectra of brain tumors

1986 • 17 citations

Alzheimer's disease histologically proven studied by MRI and MRS: Two cases

1993 • 17 citations

Human Brain Postmortem Studies of Neurotransmitters and Related Markers

1982 • 16 citations