Protection of a model enzyme (lactate dehydrogenase) against heat, urea and freeze-thaw treatment by compatible solute additives

The stabilization of proteins by osmolytes

1985 • 984 citations

Microbial water stress

1976 • 742 citations

The mechanism of cryoprotection of proteins by solutes

1988 • 542 citations

Enzyme stabilization be ectoine-type compatible solutes: protection against heating, freezing and drying

1992 • 409 citations

Counteraction of urea destabilization of protein structure by methylamine osmoregulatory compounds of elasmobranch fishes

1979 • 386 citations

Enzyme activities in concentrated solutions of glycinebetaine and other solutes

1979 • 373 citations

Proline-Protein Interactions: Protection of Structural and Functional Integrity of M4 Lactate Dehydrogenase

1994 • 131 citations

Trimethylamine-N-Oxide Counteracts Urea Effects on Rabbit Muscle Lactate Dehydrogenase Function: A Test of the Counteraction Hypothesis

1998 • 131 citations

Stabilization of Enzymes against Thermal Stress and Freeze-Drying by Mannosylglycerate

1997 • 127 citations

Effects of urea and trimethylamine-N-oxide on enzyme activity and stability

1987 • 97 citations

Production of hydroxyectoine: high cell-density cultivation and osmotic downshock of Marinococcus strain M52

1995 • 49 citations

On the selectivity of acylation of unprotected diamino acids

1968 • 42 citations

Betaine counteracts urea‐induced conformational changes and uncoupling of the human erythrocyte Ca²⁺ pump

1994 • 29 citations

Time-Dependent Effects of Trimethylamine-N-Oxide/Urea on Lactate Dehydrogenase Activity: An Unexplored Dimension of the Adaptation Paradigm

1998 • 27 citations

Salt‐stabilized globular protein structure in 7 M aqueous urea solution

1995 • 24 citations

Fluorescence Spectroscopic Study ofα-Chymotrypsin as Relevant to Catalytic Activity in Aqueous–Organic Media

1993 • 21 citations

Effects of Compatible Solutes on Mammalian Cytochrome P450 Stability

1997 • 8 citations