Heparin binding, internalization, and metabolism in vascular smooth muscle cells: I. Upregulation of heparin binding correlates with antiproliferative activity

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

Glycosaminoglycans: molecular properties, protein interactions, and role in physiological processes

1991 • 1,088 citations

Suppression by heparin of smooth muscle cell proliferation in injured arteries

1977 • 798 citations

Cultured endothelial cells produce heparinlike inhibitor of smooth muscle cell growth

1981 • 685 citations

Inhibition of rat arterial smooth muscle cell proliferation by heparin. In vivo studies with anticoagulant and nonanticoagulant heparin.

1980 • 396 citations

Inhibition of rat arterial smooth muscle cell proliferation by heparin. II. In vitro studies.

1980 • 337 citations

Inhibition of vascular smooth muscle cell growth by endothelial cell-derived heparin. Possible role of a platelet endoglycosidase.

1982 • 312 citations

Binding and internalization of heparin by vascular smooth muscle cells

1985 • 298 citations

Increased calcium influx in dystrophic muscle.

1991 • 271 citations

Kinetics of basic fibroblast growth factor binding to its receptor and heparan sulfate proteoglycan: a mechanism for cooperativity

1992 • 236 citations

Effect of heparin on vascular smooth muscle cells. I. Cell metabolism

1985 • 214 citations

Binding and endocytosis of heparin by human endothelial cells in culture

1985 • 200 citations

Heparin regulates smooth muscle S phase entry in the injured rat carotid artery.

1987 • 178 citations

Expression of basic fibroblast growth factor and its receptor by smooth muscle cells and endothelium in injured rat arteries. An en face study.

1993 • 174 citations

Heparin selectively inhibits a protein kinase C-dependent mechanism of cell cycle progression in calf aortic smooth muscle cells [published erratum appears in J Cell Biol 1990 Mar;110(3):863]

1989 • 170 citations

Heparin Prevents Vascular Smooth Muscle Cell Progression through the G1 Phase of the Cell Cycle

1989 • 168 citations

Inhibition of smooth muscle cell proliferation in injured rat arteries. Interaction of heparin with basic fibroblast growth factor.

1992 • 159 citations

Analysis of affinity and structural selectivity in the binding of proteins to glycosaminoglycans: development of a sensitive electrophoretic approach.

1991 • 153 citations

Basic fibroblast growth factor: its role in the control of smooth muscle cell migration.

1993 • 139 citations

Heparin inhibition of smooth muscle cell proliferation: A cellular site of action

1986 • 130 citations

Heparin inhibits c-fos and c-myc mRNA expression in vascular smooth muscle cells.

1990 • 124 citations

Trans-repressor activity of nuclear glycosaminoglycans on Fos and Jun/AP-1 oncoprotein-mediated transcription.

1992 • 121 citations

Heparin suppresses the induction of c-fos and c-myc mRNA in murine fibroblasts by selective inhibition of a protein kinase C-dependent pathway.

1989 • 116 citations

Heparin suppresses specific second messenger pathways for protooncogene expression in rat vascular smooth muscle cells.

1992 • 103 citations

Contrasting effects of the intermittent and continuous administration of heparin in experimental restenosis.

1994 • 102 citations

Endothelial Heparan Sulfate Proteoglycan. I. Inhibitory Effects on Smooth Muscle Cell Proliferation

1990 • 89 citations

Vascular cell-derived heparan sulfate shows coupled inhibition of basic fibroblast growth factor binding and mitogenesis in vascular smooth muscle cells.

1993 • 89 citations

Kinetics of proteoheparan sulfate synthesis, secretion, endocytosis, and catabolism by a hepatocyte cell line.

1984 • 81 citations

Identification of cell-surface heparin/heparan sulfate-binding proteins of a human uterine epithelial cell line (RL95).

1992 • 61 citations

Regulation of vascular smooth muscle cell growth by endothelial-synthesized extracellular matrices.

1987 • 59 citations

Rat vascular smooth muscle cells immortalized with SV40 large T antigen possess defined smooth muscle cell characteristics including growth inhibition by heparin

1990 • 58 citations

Heparin inhibits the attachment and growth of Balb/c‐3T3 fibroblasts on collagen substrata

1992 • 54 citations

The antiproliferative activity of arterial heparan sulfate resides in domains enriched with 2-O-sulfated uronic acid residues.

1992 • 50 citations

Heparin-like glycosaminoglycans influence growth and phenotype of human arterial smooth muscle cells in vitro. I. Evidence for reversible binding and inactivation of the platelet-derived growth factor by heparin

1992 • 49 citations

Antiproliferative capacity of synthetic dextrans on smooth muscle cell growth: the model of derivatized dextrans as heparin-like polymers

1993 • 49 citations

Fucoidan is a non-anticoagulant inhibitor of intimal hyperplasia

1992 • 47 citations

Expression of externally‐disposed heparin/heparan sulfate binding sites by uterine epithelial cells

1990 • 44 citations

Decreased susceptibility of cultured smooth muscle cells from SHR rats to growth inhibition by heparin

1989 • 41 citations

Heparin potentiation of 3T3‐adipocyte stimulated angiogenesis: Mechanisms of action on endothelial cells

1986 • 37 citations

Heparin binding, internalization, and metabolism in vascular smooth muscle cells: II. Degradation and secretion in sensitive and resistant cells

1995 • 31 citations

Isolation of heparin-insensitive aortic smooth muscle cells. Growth and differentiation.

1993 • 25 citations

Heparin interaction with cultured cells: Possible role of fibronectin in uncoupling surface binding and endocytosis

1983 • 24 citations

Heparin and heparan sulfate binding sites on B‐16 melanoma cells

1988 • 22 citations

Isolation of vascular smooth muscle cell cultures with altered responsiveness to the antiproliferative effect of heparin

1996 • 16 citations

Regulation of smooth muscle cell function by heparin

1992 • 12 citations

Properties of heparin binding to purified plasma membranes from bovine granulosa cells

1989 • 10 citations